Gene description for HEATR3
Gene name HEAT repeat containing 3
Gene symbol HEATR3
Other names/aliases SYO1
Species Homo sapiens
 Database cross references - HEATR3
ExoCarta ExoCarta_55027
Vesiclepedia VP_55027
Entrez Gene 55027
HGNC 26087
MIM 614951
UniProt Q7Z4Q2  
 HEATR3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for HEATR3
Molecular Function
    unfolded protein binding GO:0051082 IBA
Biological Process
    protein import into nucleus GO:0006606 IBA
    protein import into nucleus GO:0006606 IMP
    ribosomal large subunit biogenesis GO:0042273 IBA
    ribosomal large subunit biogenesis GO:0042273 IMP
    erythrocyte maturation GO:0043249 IMP
 Experiment description of studies that identified HEATR3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HEATR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DPY19L1 23333
Affinity Capture-MS Homo sapiens
2 RPL11 6135
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LDHA 3939
Affinity Capture-MS Homo sapiens
4 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TRMT1L 81627
Affinity Capture-MS Homo sapiens
6 CLIP1 6249
Affinity Capture-MS Homo sapiens
7 VTI1B 10490
Affinity Capture-MS Homo sapiens
8 ZNF346  
Affinity Capture-MS Homo sapiens
9 LDHB 3945
Affinity Capture-MS Homo sapiens
10 TYW1B  
Affinity Capture-MS Homo sapiens
11 HCST  
Affinity Capture-MS Homo sapiens
12 TMED4 222068
Affinity Capture-MS Homo sapiens
13 TSR3  
Affinity Capture-MS Homo sapiens
14 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 C9orf78 51759
Affinity Capture-MS Homo sapiens
16 UQCRB 7381
Affinity Capture-MS Homo sapiens
17 TMEM186  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SSB 6741
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 LNPEP 4012
Affinity Capture-MS Homo sapiens
20 PTPN1 5770
Affinity Capture-MS Homo sapiens
21 GLCE 26035
Affinity Capture-MS Homo sapiens
22 C5AR1  
Affinity Capture-MS Homo sapiens
23 PNKD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 LRP10 26020
Affinity Capture-MS Homo sapiens
25 CTXN1  
Affinity Capture-MS Homo sapiens
26 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
27 Tbc1d7  
Affinity Capture-MS Mus musculus
28 SURF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 UXS1 80146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SCARA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 IARS2 55699
Affinity Capture-MS Homo sapiens
32 HOXA5  
Affinity Capture-MS Homo sapiens
33 SDHB 6390
Affinity Capture-MS Homo sapiens
34 Tube1  
Affinity Capture-MS Mus musculus
35 FAM174A 345757
Affinity Capture-MS Homo sapiens
36 DGKE  
Affinity Capture-MS Homo sapiens
37 TIMM17B  
Affinity Capture-MS Homo sapiens
38 NPM1 4869
Affinity Capture-MS Homo sapiens
39 SLC27A2 11001
Affinity Capture-MS Homo sapiens
40 GRAMD1C  
Affinity Capture-MS Homo sapiens
41 SEMA4C 54910
Affinity Capture-MS Homo sapiens
42 ATP5O 539
Affinity Capture-MS Homo sapiens
43 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TACSTD2 4070
Affinity Capture-MS Homo sapiens
45 TMEM192 201931
Affinity Capture-MS Homo sapiens
46 ITFG3 83986
Affinity Capture-MS Homo sapiens
47 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
48 LMAN2 10960
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 MAVS 57506
Affinity Capture-MS Homo sapiens
50 NCK1 4690
Affinity Capture-MS Homo sapiens
51 GYPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 NDUFS5 4725
Affinity Capture-MS Homo sapiens
53 GPR17 2840
Affinity Capture-MS Homo sapiens
54 DHX36 170506
Affinity Capture-MS Homo sapiens
55 MDH2 4191
Affinity Capture-MS Homo sapiens
56 TST 7263
Affinity Capture-MS Homo sapiens
57 SRP9 6726
Affinity Capture-MS Homo sapiens
58 HNRNPA0 10949
Affinity Capture-MS Homo sapiens
59 C19orf38  
Affinity Capture-MS Homo sapiens
60 TNPO1 3842
Affinity Capture-MS Homo sapiens
61 EXOG 9941
Affinity Capture-MS Homo sapiens
62 RBM28 55131
Affinity Capture-MS Homo sapiens
63 PLD1 5337
Affinity Capture-MS Homo sapiens
64 GLE1 2733
Affinity Capture-MS Homo sapiens
65 COMTD1 118881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 DHRS2 10202
Affinity Capture-MS Homo sapiens
67 RPL5 6125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 ST6GAL1 6480
Affinity Capture-MS Homo sapiens
69 ACADM 34
Affinity Capture-MS Homo sapiens
70 CBX6  
Affinity Capture-MS Homo sapiens
71 CENPQ  
Affinity Capture-MS Homo sapiens
72 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
73 DHX9 1660
Affinity Capture-MS Homo sapiens
74 Ptbp1 19205
Affinity Capture-MS Mus musculus
75 RRP1B 23076
Affinity Capture-MS Homo sapiens
76 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 CEBPA  
Protein-peptide Homo sapiens
78 Ncbp2  
Affinity Capture-MS Mus musculus
79 ST13 6767
Co-fractionation Homo sapiens
80 MLNR  
Affinity Capture-MS Homo sapiens
81 LRFN4  
Affinity Capture-MS Homo sapiens
82 CA9 768
Affinity Capture-MS Homo sapiens
83 Cep131  
Affinity Capture-MS Mus musculus
84 VCAN 1462
Affinity Capture-MS Homo sapiens
85 HNRNPD 3184
Affinity Capture-MS Homo sapiens
86 ACAT1 38
Affinity Capture-MS Homo sapiens
87 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 SGPL1 8879
Affinity Capture-MS Homo sapiens
89 EFNA4  
Affinity Capture-MS Homo sapiens
90 HADHB 3032
Affinity Capture-MS Homo sapiens
91 HADHA 3030
Affinity Capture-MS Homo sapiens
92 AIFM1 9131
Affinity Capture-MS Homo sapiens
93 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 BTNL9  
Affinity Capture-MS Homo sapiens
95 PNPT1 87178
Affinity Capture-MS Homo sapiens
96 CD83  
Affinity Capture-MS Homo sapiens
97 YTHDC2 64848
Affinity Capture-MS Homo sapiens
98 FZD10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 LETM1 3954
Affinity Capture-MS Homo sapiens
100 ETFB 2109
Affinity Capture-MS Homo sapiens
101 EGFR 1956
Affinity Capture-MS Homo sapiens
102 HTR2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 SDC2 6383
Affinity Capture-MS Homo sapiens
104 SGTB  
Affinity Capture-MS Homo sapiens
105 NCAPH 23397
Affinity Capture-MS Homo sapiens
106 C1QBP 708
Affinity Capture-MS Homo sapiens
107 C3orf18  
Affinity Capture-MS Homo sapiens
108 NDUFB3 4709
Affinity Capture-MS Homo sapiens
109 RPA3 6119
Proximity Label-MS Homo sapiens
110 ESD 2098
Affinity Capture-MS Homo sapiens
111 PTPRN  
Affinity Capture-MS Homo sapiens
112 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 DDRGK1 65992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 B3GAT3 26229
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 NDUFA3  
Affinity Capture-MS Homo sapiens
116 AKT1 207
Biochemical Activity Homo sapiens
117 DLAT 1737
Affinity Capture-MS Homo sapiens
118 SMS 6611
Affinity Capture-MS Homo sapiens
119 DSP 1832
Affinity Capture-MS Homo sapiens
120 PIP5K1A 8394
Affinity Capture-MS Homo sapiens
121 GYPA  
Affinity Capture-MS Homo sapiens
122 MTHFD2 10797
Affinity Capture-MS Homo sapiens
123 CS 1431
Affinity Capture-MS Homo sapiens
124 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
125 FASN 2194
Positive Genetic Homo sapiens
126 MRPS2 51116
Affinity Capture-MS Homo sapiens
127 ATP5J 522
Affinity Capture-MS Homo sapiens
128 NDUFAF2  
Affinity Capture-MS Homo sapiens
129 KDM1B  
Affinity Capture-MS Homo sapiens
130 LONP1 9361
Affinity Capture-MS Homo sapiens
131 TPTE  
Affinity Capture-MS Homo sapiens
132 ALDH1B1 219
Affinity Capture-MS Homo sapiens
133 COX5A 9377
Affinity Capture-MS Homo sapiens
134 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 EFNB1 1947
Affinity Capture-MS Homo sapiens
136 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
137 FEM1B 10116
Affinity Capture-MS Homo sapiens
138 PTGER3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 OAT 4942
Affinity Capture-MS Homo sapiens
140 TRAP1 10131
Affinity Capture-MS Homo sapiens
141 CHRM3 1131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 Rprd1b  
Affinity Capture-MS Mus musculus
143 SEC62 7095
Affinity Capture-MS Homo sapiens
144 Ranbp2  
Affinity Capture-MS Mus musculus
145 TPST2 8459
Affinity Capture-MS Homo sapiens
146 EHMT1  
Affinity Capture-MS Homo sapiens
147 DNAJC1 64215
Affinity Capture-MS Homo sapiens
148 GOLM1 51280
Affinity Capture-MS Homo sapiens
149 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
151 C11orf87  
Affinity Capture-MS Homo sapiens
152 B3GNT8  
Affinity Capture-MS Homo sapiens
153 TIMM44 10469
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HEATR3 is involved
No pathways found





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