Gene description for SLC27A2
Gene name solute carrier family 27 (fatty acid transporter), member 2
Gene symbol SLC27A2
Other names/aliases ACSVL1
FACVL1
FATP2
HsT17226
VLACS
VLCS
hFACVL1
Species Homo sapiens
 Database cross references - SLC27A2
ExoCarta ExoCarta_11001
Vesiclepedia VP_11001
Entrez Gene 11001
HGNC 10996
MIM 603247
UniProt O14975  
 SLC27A2 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 19056867    
 Gene ontology annotations for SLC27A2
Molecular Function
    long-chain fatty acid-CoA ligase activity GO:0004467 IBA
    long-chain fatty acid-CoA ligase activity GO:0004467 IDA
    long-chain fatty acid-CoA ligase activity GO:0004467 TAS
    long-chain fatty acid transmembrane transporter activity GO:0005324 IBA
    long-chain fatty acid transmembrane transporter activity GO:0005324 IDA
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 IPI
    very long-chain fatty acid-CoA ligase activity GO:0031957 IDA
    arachidonate-CoA ligase activity GO:0047676 IEA
    cholate-CoA ligase activity GO:0047747 IEA
    phytanate-CoA ligase activity GO:0050197 IDA
    phytanate-CoA ligase activity GO:0050197 TAS
    pristanate-CoA ligase activity GO:0070251 IDA
    pristanate-CoA ligase activity GO:0070251 TAS
    oleate transmembrane transporter activity GO:1901480 IEA
Biological Process
    fatty acid alpha-oxidation GO:0001561 IDA
    fatty acid alpha-oxidation GO:0001561 TAS
    long-chain fatty acid metabolic process GO:0001676 IBA
    long-chain fatty acid metabolic process GO:0001676 IDA
    fatty acid beta-oxidation GO:0006635 IDA
    bile acid biosynthetic process GO:0006699 IDA
    bile acid biosynthetic process GO:0006699 TAS
    bile acid metabolic process GO:0008206 IBA
    very long-chain fatty acid catabolic process GO:0042760 IEA
    long-chain fatty acid import into cell GO:0044539 IBA
    long-chain fatty acid import into cell GO:0044539 IDA
    fatty-acyl-CoA biosynthetic process GO:0046949 TAS
    methyl-branched fatty acid metabolic process GO:0097089 IDA
Subcellular Localization
    peroxisomal membrane GO:0005778 IBA
    peroxisomal membrane GO:0005778 IDA
    peroxisomal membrane GO:0005778 TAS
    endoplasmic reticulum lumen GO:0005788 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    specific granule membrane GO:0035579 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC27A2 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC27A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ROPN1  
Affinity Capture-MS Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 HSD17B11 51170
Proximity Label-MS Homo sapiens
4 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 BZW2 28969
Affinity Capture-MS Homo sapiens
6 EIF2B2 8892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KPNB1 3837
Affinity Capture-MS Homo sapiens
8 IGHM 3507
Affinity Capture-MS Homo sapiens
9 UBC 7316
Reconstituted Complex Homo sapiens
10 LRRC73  
Affinity Capture-MS Homo sapiens
11 KPNA2 3838
Affinity Capture-MS Homo sapiens
12 LPCAT1 79888
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 OTOA  
Affinity Capture-MS Homo sapiens
14 ABCD1 215
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
15 HEATR3 55027
Affinity Capture-MS Homo sapiens
16 KIF23 9493
Affinity Capture-MS Homo sapiens
17 CTDSPL2  
Affinity Capture-MS Homo sapiens
18 PIGH  
Affinity Capture-MS Homo sapiens
19 PNPLA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 C3orf52  
Affinity Capture-MS Homo sapiens
21 Ubr5  
Affinity Capture-MS Mus musculus
22 CCDC47 57003
Affinity Capture-MS Homo sapiens
23 SMPD1 6609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ATP6V0D1 9114
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 DFNA5 1687
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CALR 811
Co-fractionation Homo sapiens
27 PPP1R15B  
Affinity Capture-MS Homo sapiens
28 RNF123 63891
Affinity Capture-MS Homo sapiens
29 FAM177A1 283635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 NCSTN 23385
Co-fractionation Homo sapiens
31 KIF14 9928
Affinity Capture-MS Homo sapiens
32 UNC45A 55898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 HPS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
35 GPD1 2819
Affinity Capture-MS Homo sapiens
36 PPP6R2 9701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 CCNB1 891
Affinity Capture-MS Homo sapiens
38 BCL2L2 599
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 GPR182  
Affinity Capture-MS Homo sapiens
40 YWHAQ 10971
Reconstituted Complex Homo sapiens
41 GNAI2 2771
Affinity Capture-MS Homo sapiens
42 HEATR1 55127
Affinity Capture-MS Homo sapiens
43 RANBP6 26953
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 PNMA6A  
Affinity Capture-MS Homo sapiens
45 CHRNA1  
Affinity Capture-MS Homo sapiens
46 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SLC33A1 9197
Affinity Capture-MS Homo sapiens
48 FAM73B  
Affinity Capture-MS Homo sapiens
49 NKAIN1  
Affinity Capture-MS Homo sapiens
50 EID3  
Affinity Capture-MS Homo sapiens
51 IPO5 3843
Affinity Capture-MS Homo sapiens
52 TTYH1  
Affinity Capture-MS Homo sapiens
53 SDHA 6389
Co-fractionation Homo sapiens
54 ZDHHC12  
Affinity Capture-MS Homo sapiens
55 CAMK1D 57118
Affinity Capture-MS Homo sapiens
56 FAM134A 79137
Affinity Capture-MS Homo sapiens
57 SPC24 147841
Affinity Capture-MS Homo sapiens
58 CUL3 8452
Affinity Capture-MS Homo sapiens
59 FAM63B 54629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 TMEM169  
Affinity Capture-MS Homo sapiens
61 XPO6 23214
Affinity Capture-MS Homo sapiens
62 TUBA4A 7277
Affinity Capture-MS Homo sapiens
63 TSPAN5 10098
Affinity Capture-MS Homo sapiens
64 SAAL1 113174
Affinity Capture-MS Homo sapiens
65 FAM134C 162427
Affinity Capture-MS Homo sapiens
66 CNR2  
Affinity Capture-MS Homo sapiens
67 RAB2B 84932
Affinity Capture-MS Homo sapiens
68 GPR45  
Affinity Capture-MS Homo sapiens
69 SCGB2A2  
Affinity Capture-MS Homo sapiens
70 CISD2 493856
Affinity Capture-MS Homo sapiens
71 METTL9 51108
Affinity Capture-MS Homo sapiens
72 DYM  
Affinity Capture-MS Homo sapiens
73 MRPL34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 UBAC1 10422
Affinity Capture-MS Homo sapiens
75 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
76 PRKCSH 5589
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
78 EXOC8 149371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 VAC14 55697
Affinity Capture-MS Homo sapiens
80 TSPAN15 23555
Affinity Capture-MS Homo sapiens
81 SFTPA2  
Affinity Capture-MS Homo sapiens
82 FASN 2194
Affinity Capture-MS Homo sapiens
83 ARMC6 93436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 HAUS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 ZNRF4  
Affinity Capture-MS Homo sapiens
86 CUL4A 8451
Affinity Capture-MS Homo sapiens
87 Tnpo1 238799
Affinity Capture-MS Mus musculus
88 PEX5 5830
Protein-peptide Homo sapiens
89 KCNE4  
Affinity Capture-MS Homo sapiens
90 CNPPD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 DERL1 79139
Proximity Label-MS Homo sapiens
92 RNF139  
Affinity Capture-MS Homo sapiens
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