Gene description for SLC27A2
Gene name solute carrier family 27 (fatty acid transporter), member 2
Gene symbol SLC27A2
Other names/aliases ACSVL1
FACVL1
FATP2
HsT17226
VLACS
VLCS
hFACVL1
Species Homo sapiens
 Database cross references - SLC27A2
ExoCarta ExoCarta_11001
Vesiclepedia VP_11001
Entrez Gene 11001
HGNC 10996
MIM 603247
UniProt O14975  
 SLC27A2 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 19056867    
 Gene ontology annotations for SLC27A2
Molecular Function
    pristanate-CoA ligase activity GO:0070251 IDA
    long-chain fatty acid-CoA ligase activity GO:0004467 IDA
    fatty acid transporter activity GO:0015245 IEA
    receptor binding GO:0005102 IPI
    phytanate-CoA ligase activity GO:0050197 IDA
    very long-chain fatty acid-CoA ligase activity GO:0031957 IDA
    enzyme binding GO:0019899 IPI
    ATP binding GO:0005524 IEA
Biological Process
    very long-chain fatty acid catabolic process GO:0042760 IEA
    fatty acid beta-oxidation GO:0006635 IDA
    long-chain fatty acid import GO:0044539 IDA
    small molecule metabolic process GO:0044281 TAS
    bile acid biosynthetic process GO:0006699 TAS
    bile acid metabolic process GO:0008206 TAS
    cellular lipid metabolic process GO:0044255 TAS
    fatty acid alpha-oxidation GO:0001561 TAS
    methyl-branched fatty acid metabolic process GO:0097089 IDA
    long-chain fatty acid metabolic process GO:0001676 IDA
Subcellular Localization
    integral component of peroxisomal membrane GO:0005779 IDA
    mitochondrion GO:0005739 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
    endoplasmic reticulum lumen GO:0005788 IDA
    extracellular exosome GO:0070062 IDA
    integral component of endoplasmic reticulum membrane GO:0030176 IDA
    peroxisomal membrane GO:0005778 TAS
 Experiment description of studies that identified SLC27A2 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC27A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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