Gene description for FAM63B
Gene name family with sequence similarity 63, member B
Gene symbol FAM63B
Other names/aliases -
Species Homo sapiens
 Database cross references - FAM63B
ExoCarta ExoCarta_54629
Vesiclepedia VP_54629
Entrez Gene 54629
HGNC 26954
UniProt Q8NBR6  
 FAM63B identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FAM63B
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IEA
    cysteine-type carboxypeptidase activity GO:0016807 IBA
    cysteine-type carboxypeptidase activity GO:0016807 IDA
    K48-linked polyubiquitin modification-dependent protein binding GO:0036435 IDA
    K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IDA
    K11-linked polyubiquitin modification-dependent protein binding GO:0071795 IDA
    K6-linked polyubiquitin modification-dependent protein binding GO:0071796 IDA
    K48-linked deubiquitinase activity GO:1990380 IBA
    K48-linked deubiquitinase activity GO:1990380 IDA
Biological Process
    proteolysis GO:0006508 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified FAM63B in sEVs
1
Experiment ID 211
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FAM63B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 XXYLT1 152002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GNPAT 8443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PRAF2 11230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CTU1 90353
Affinity Capture-MS Homo sapiens
5 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 GPX1 2876
Affinity Capture-MS Homo sapiens
7 PPM1B 5495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TUBB8 347688
Affinity Capture-MS Homo sapiens
9 IKBIP 121457
Affinity Capture-MS Homo sapiens
10 UBC 7316
Reconstituted Complex Homo sapiens
11 KCNJ11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SLC27A6  
Affinity Capture-MS Homo sapiens
13 KLC1 3831
Affinity Capture-Western Homo sapiens
14 ARL8B 55207
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PTRH2 51651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 RETSAT 54884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CYP2J2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
19 HSDL1 83693
Affinity Capture-MS Homo sapiens
20 CADPS  
Affinity Capture-MS Homo sapiens
21 DNAJC1 64215
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 GNA13 10672
Affinity Capture-MS Homo sapiens
23 SLC27A2 11001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ARL13B 200894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ALG11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SLC2A8 29988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 SCCPDH 51097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MBLAC2 153364
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM63B is involved
No pathways found





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