Gene description for SLC2A8
Gene name solute carrier family 2 (facilitated glucose transporter), member 8
Gene symbol SLC2A8
Other names/aliases GLUT8
GLUTX1
Species Homo sapiens
 Database cross references - SLC2A8
ExoCarta ExoCarta_29988
Vesiclepedia VP_29988
Entrez Gene 29988
HGNC 13812
MIM 605245
UniProt Q9NY64  
 SLC2A8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC2A8
Molecular Function
    fructose transmembrane transporter activity GO:0005353 ISS
    D-glucose binding GO:0005536 IEA
    dehydroascorbic acid transmembrane transporter activity GO:0033300 ISS
    D-glucose transmembrane transporter activity GO:0055056 IBA
    D-glucose transmembrane transporter activity GO:0055056 ISS
    D-glucose transmembrane transporter activity GO:0055056 TAS
Biological Process
    response to hypoxia GO:0001666 IEA
    carbohydrate metabolic process GO:0005975 TAS
    insulin receptor signaling pathway GO:0008286 IEA
    hexose transmembrane transport GO:0008645 TAS
    fructose transmembrane transport GO:0015755 ISS
    dehydroascorbic acid transport GO:0070837 ISS
    D-glucose transmembrane transport GO:1904659 IBA
    D-glucose transmembrane transport GO:1904659 ISS
Subcellular Localization
    lysosomal membrane GO:0005765 HDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IBA
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
 Experiment description of studies that identified SLC2A8 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC2A8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IMMT 10989
Affinity Capture-MS Homo sapiens
2 PFKFB4 5210
Affinity Capture-MS Homo sapiens
3 MTFP1  
Affinity Capture-MS Homo sapiens
4 CHCHD6 84303
Affinity Capture-MS Homo sapiens
5 SNX9 51429
Affinity Capture-MS Homo sapiens
6 KLK8 11202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 GPR17 2840
Affinity Capture-MS Homo sapiens
8 DHRS9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MTX2 10651
Affinity Capture-MS Homo sapiens
10 LAMP1 3916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 REEP5 7905
Affinity Capture-MS Homo sapiens
13 TUBB8 347688
Affinity Capture-MS Homo sapiens
14 SLC25A40  
Affinity Capture-MS Homo sapiens
15 C2CD2 25966
Affinity Capture-MS Homo sapiens
16 SAMM50 25813
Affinity Capture-MS Homo sapiens
17 CLEC4A  
Affinity Capture-MS Homo sapiens
18 CHIA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TMEM263 90488
Affinity Capture-MS Homo sapiens
20 CD79A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 FAM63B 54629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 FOLH1 2346
Affinity Capture-MS Homo sapiens
23 PRKAG1 5571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TM9SF3 56889
Affinity Capture-MS Homo sapiens
25 ARMC6 93436
Affinity Capture-MS Homo sapiens
26 RPL38 6169
Affinity Capture-MS Homo sapiens
27 GOLGA5 9950
Affinity Capture-MS Homo sapiens
28 GLG1 2734
Affinity Capture-MS Homo sapiens
29 TMEM41B 440026
Affinity Capture-MS Homo sapiens
30 HSPA1A 3303
Affinity Capture-MS Homo sapiens
31 TIMM23 100287932
Affinity Capture-MS Homo sapiens
32 CRISP3  
Affinity Capture-MS Homo sapiens
33 BDKRB2  
Two-hybrid Homo sapiens
34 IARS 3376
Affinity Capture-MS Homo sapiens
35 AGPAT2  
Affinity Capture-MS Homo sapiens
36 OSBPL8 114882
Affinity Capture-MS Homo sapiens
37 ANKRD26 22852
Affinity Capture-MS Homo sapiens
38 STX17 55014
Affinity Capture-MS Homo sapiens
39 MTX3  
Affinity Capture-MS Homo sapiens
40 ANKRD13A 88455
Affinity Capture-MS Homo sapiens
41 REEP6  
Affinity Capture-MS Homo sapiens
42 FAF1 11124
Affinity Capture-MS Homo sapiens
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