Gene description for KLK8
Gene name kallikrein-related peptidase 8
Gene symbol KLK8
Other names/aliases HNP
NP
NRPN
PRSS19
TADG14
Species Homo sapiens
 Database cross references - KLK8
ExoCarta ExoCarta_11202
Entrez Gene 11202
HGNC 6369
MIM 605644
UniProt O60259  
 KLK8 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for KLK8
Molecular Function
    protein binding GO:0005515 IPI
    serine-type endopeptidase activity GO:0004252 IDA
Biological Process
    memory GO:0007613 ISS
    proteolysis GO:0006508 IEA
    synapse organization GO:0050808 IEA
    negative regulation of myelination GO:0031642 ISS
    neuron projection morphogenesis GO:0048812 ISS
    response to wounding GO:0009611 ISS
    cell death GO:0008219 ISS
    regulation of synapse organization GO:0050807 ISS
    negative regulation of axon regeneration GO:0048681 ISS
    keratinocyte proliferation GO:0043616 ISS
Subcellular Localization
    extracellular space GO:0005615 ISS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified KLK8 in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KLK8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KLK8 is involved
No pathways found





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