Gene description for RAB39B
Gene name RAB39B, member RAS oncogene family
Gene symbol RAB39B
Other names/aliases MRX72
WSMN
Species Homo sapiens
 Database cross references - RAB39B
ExoCarta ExoCarta_116442
Vesiclepedia VP_116442
Entrez Gene 116442
HGNC 16499
MIM 300774
UniProt Q96DA2  
 RAB39B identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for RAB39B
Molecular Function
    GTPase activity GO:0003924 IBA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    myosin V binding GO:0031489 IBA
    myosin V binding GO:0031489 IPI
Biological Process
    autophagy GO:0006914 IEA
    regulation of autophagy GO:0010506 IMP
    protein transport GO:0015031 IEA
    vesicle-mediated transport GO:0016192 IBA
    vesicle-mediated transport GO:0016192 ISS
    Rab protein signal transduction GO:0032482 IEA
    synapse organization GO:0050808 ISS
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IEA
    cytoplasmic vesicle membrane GO:0030659 IEA
    vesicle GO:0031982 IDA
    neuron projection GO:0043005 IDA
 Experiment description of studies that identified RAB39B in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RAB39B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GRPR  
Affinity Capture-MS Homo sapiens
2 TRIP6 7205
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ART3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 KLK8 11202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TRIM4 89122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HBS1L 10767
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CBL 867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TNFSF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ZDHHC17 23390
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
12 LRRC15 131578
Affinity Capture-MS Homo sapiens
13 DUSP14 11072
Affinity Capture-MS Homo sapiens
14 FPR1  
Affinity Capture-MS Homo sapiens
15 GCGR  
Affinity Capture-MS Homo sapiens
16 LAMP2 3920
Affinity Capture-MS Homo sapiens
17 RAB14 51552
Cross-Linking-MS (XL-MS) Homo sapiens
18 KPNA2 3838
Affinity Capture-MS Homo sapiens
19 RUFY1 80230
Two-hybrid Homo sapiens
20 NDUFA4 4697
Affinity Capture-MS Homo sapiens
21 CSNK1E 1454
Affinity Capture-MS Homo sapiens
22 OPRL1 4987
Affinity Capture-MS Homo sapiens
23 TMEM55B 90809
Affinity Capture-MS Homo sapiens
24 SLC39A9 55334
Affinity Capture-MS Homo sapiens
25 TOMM22 56993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
27 ALPI  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 LRP1 4035
Affinity Capture-MS Homo sapiens
29 SLC18A2  
Affinity Capture-MS Homo sapiens
30 EFHD1  
Affinity Capture-MS Homo sapiens
31 CARM1 10498
Affinity Capture-MS Homo sapiens
32 CTLA4  
Affinity Capture-MS Homo sapiens
33 SELENBP1 8991
Affinity Capture-MS Homo sapiens
34 DSCR3 10311
Two-hybrid Homo sapiens
35 IMPAD1 54928
Affinity Capture-MS Homo sapiens
36 RAD50 10111
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PLCD1 5333
Affinity Capture-MS Homo sapiens
38 RAB33B 83452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 H3F3B 3021
Affinity Capture-MS Homo sapiens
40 RAB3GAP1 22930
Two-hybrid Homo sapiens
41 SGSM3  
Two-hybrid Homo sapiens
42 CST9L  
Affinity Capture-MS Homo sapiens
43 KLRC1  
Affinity Capture-MS Homo sapiens
44 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
45 CLEC16A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 PMEL 6490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
48 WHAMM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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