Gene description for SLC39A9
Gene name solute carrier family 39, member 9
Gene symbol SLC39A9
Other names/aliases ZIP-9
ZIP9
Species Homo sapiens
 Database cross references - SLC39A9
ExoCarta ExoCarta_55334
Vesiclepedia VP_55334
Entrez Gene 55334
HGNC 20182
UniProt Q9NUM3  
 SLC39A9 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC39A9
Molecular Function
    G protein-coupled receptor activity GO:0004930 IDA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    zinc ion transmembrane transporter activity GO:0005385 IMP
    androgen binding GO:0005497 IDA
    protein binding GO:0005515 IPI
    zinc efflux transmembrane transporter activity GO:0022883 IDA
Biological Process
    intracellular zinc ion homeostasis GO:0006882 IDA
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    bicellular tight junction assembly GO:0070830 ISS
    zinc ion transmembrane transport GO:0071577 IDA
    regulation of vascular endothelial cell proliferation GO:1905562 IMP
    regulation of cellular response to testosterone stimulus GO:2000654 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 IDA
    trans-Golgi network GO:0005802 IDA
    plasma membrane GO:0005886 IDA
    mitochondrial membrane GO:0031966 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified SLC39A9 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC39A9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MTFP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MPC2 25874
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 DNM1 1759
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SLC25A24 29957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 FASN 2194
Negative Genetic Homo sapiens
6 SRPR 6734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 APOOL 139322
Affinity Capture-MS Homo sapiens
9 MTX1 4580
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DYNC1I2 1781
Proximity Label-MS Homo sapiens
11 HPCAL1 3241
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 B4GALT5 9334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 RIF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NEK7 140609
Affinity Capture-MS Homo sapiens
15 FKRP 79147
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CANT1 124583
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 METTL16 79066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 STIM1 6786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 RMND1 55005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CDC23 8697
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RAB39B 116442
Affinity Capture-MS Homo sapiens
22 TTK 7272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 DDX19B 11269
Affinity Capture-MS Homo sapiens
24 MSH3 4437
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 HIP1R 9026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CPT1A 1374
Affinity Capture-MS Homo sapiens
27 CCDC132 55610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 NXF1 10482
Affinity Capture-RNA Homo sapiens
29 PXMP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PDXDC1 23042
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 IDH2 3418
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TTI2 80185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 MOV10 4343
Affinity Capture-RNA Homo sapiens
34 SFXN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 OSTC 58505
Affinity Capture-MS Homo sapiens
36 TBRG4 9238
Affinity Capture-MS Homo sapiens
37 NR2F2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TPST2 8459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PTPRK 5796
Affinity Capture-MS Homo sapiens
40 SLC25A17 10478
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CD44 960
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 GOLM1 51280
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 KIAA0368 23392
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 A4GALT  
Affinity Capture-MS Homo sapiens
45 BDH1 622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 XPO7 23039
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 HELLS 3070
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 MTX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 SYNGR3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 ABCB8 11194
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 DNAJC13 23317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC39A9 is involved
No pathways found





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