Gene description for TBRG4
Gene name transforming growth factor beta regulator 4
Gene symbol TBRG4
Other names/aliases CPR2
FASTKD4
Species Homo sapiens
 Database cross references - TBRG4
ExoCarta ExoCarta_9238
Vesiclepedia VP_9238
Entrez Gene 9238
HGNC 17443
MIM 611325
UniProt Q969Z0  
 TBRG4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TBRG4
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    protein binding GO:0005515 IPI
Biological Process
    mitochondrial RNA processing GO:0000963 IBA
    positive regulation of cell population proliferation GO:0008284 TAS
    mRNA metabolic process GO:0016071 IMP
    regulation of mitochondrial mRNA stability GO:0044528 IBA
    regulation of mitochondrial mRNA stability GO:0044528 IMP
    regulation of cell cycle GO:0051726 TAS
    mitochondrial mRNA processing GO:0090615 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 TAS
    ribonucleoprotein granule GO:0035770 IBA
 Experiment description of studies that identified TBRG4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TBRG4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LIME1 54923
Two-hybrid Homo sapiens
2 SHC1 6464
Proximity Label-MS Homo sapiens
3 ACOT9 23597
Proximity Label-MS Homo sapiens
4 FA2H  
Affinity Capture-MS Homo sapiens
5 C9orf78 51759
Affinity Capture-MS Homo sapiens
6 MRPL27 51264
Proximity Label-MS Homo sapiens
7 SUPV3L1 6832
Proximity Label-MS Homo sapiens
8 APEX1 328
Affinity Capture-RNA Homo sapiens
9 SLC18A2  
Affinity Capture-MS Homo sapiens
10 MRPL13  
Proximity Label-MS Homo sapiens
11 IARS2 55699
Proximity Label-MS Homo sapiens
12 FAM174A 345757
Affinity Capture-MS Homo sapiens
13 ETFA 2108
Proximity Label-MS Homo sapiens
14 POLRMT 5442
Proximity Label-MS Homo sapiens
15 NDUFAB1 4706
Proximity Label-MS Homo sapiens
16 SLC30A9 10463
Proximity Label-MS Homo sapiens
17 BCS1L 617
Proximity Label-MS Homo sapiens
18 VWA8 23078
Proximity Label-MS Homo sapiens
19 MRPL47 57129
Proximity Label-MS Homo sapiens
20 KIF14 9928
Affinity Capture-MS Homo sapiens
21 RBMX 27316
Proximity Label-MS Homo sapiens
22 HSPA9 3313
Proximity Label-MS Homo sapiens
23 NT5DC2 64943
Proximity Label-MS Homo sapiens
24 COMTD1 118881
Affinity Capture-MS Homo sapiens
25 MRPS6  
Proximity Label-MS Homo sapiens
26 TNFSF8  
Affinity Capture-MS Homo sapiens
27 MEOX2  
Two-hybrid Homo sapiens
28 BICD2 23299
Two-hybrid Homo sapiens
29 THG1L 54974
Proximity Label-MS Homo sapiens
30 DBT 1629
Proximity Label-MS Homo sapiens
31 ACN9  
Proximity Label-MS Homo sapiens
32 MRPL41 64975
Proximity Label-MS Homo sapiens
33 ANLN 54443
Affinity Capture-MS Homo sapiens
34 PTN  
Two-hybrid Homo sapiens
35 MRPL14 64928
Proximity Label-MS Homo sapiens
36 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 EARS2  
Proximity Label-MS Homo sapiens
38 WBSCR16  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
39 HADHA 3030
Proximity Label-MS Homo sapiens
40 MTIF2 4528
Proximity Label-MS Homo sapiens
41 BTNL9  
Affinity Capture-MS Homo sapiens
42 MRPL24  
Proximity Label-MS Homo sapiens
43 HARS2 23438
Proximity Label-MS Homo sapiens
44 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 MRPL16  
Proximity Label-MS Homo sapiens
46 SYT6  
Affinity Capture-MS Homo sapiens
47 FAHD1 81889
Affinity Capture-MS Homo sapiens
48 GADD45GIP1  
Proximity Label-MS Homo sapiens
49 VARS2  
Proximity Label-MS Homo sapiens
50 KRT27 342574
Two-hybrid Homo sapiens
51 KIAA1467 57613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 HNRNPR 10236
Proximity Label-MS Homo sapiens
53 RPA3 6119
Proximity Label-MS Homo sapiens
54 DLST 1743
Proximity Label-MS Homo sapiens
55 COX2 4513
Proximity Label-MS Homo sapiens
56 DLAT 1737
Proximity Label-MS Homo sapiens
57 MRPL18 29074
Proximity Label-MS Homo sapiens
58 HSPE1 3336
Proximity Label-MS Homo sapiens
59 GLS 2744
Proximity Label-MS Homo sapiens
60 ATP5J 522
Proximity Label-MS Homo sapiens
61 CLPX 10845
Proximity Label-MS Homo sapiens
62 HIST1H2AC 8334
Proximity Label-MS Homo sapiens
63 COQ5  
Proximity Label-MS Homo sapiens
64 NME4 4833
Proximity Label-MS Homo sapiens
65 SRSF9 8683
Proximity Label-MS Homo sapiens
66 MRPS18C  
Proximity Label-MS Homo sapiens
67 UQCC1 55245
Proximity Label-MS Homo sapiens
68 COX5A 9377
Proximity Label-MS Homo sapiens
69 WIF1 11197
Affinity Capture-MS Homo sapiens
70 OAT 4942
Proximity Label-MS Homo sapiens
71 NDUFAF3 25915
Proximity Label-MS Homo sapiens
72 LARS2 23395
Proximity Label-MS Homo sapiens
73 HNRNPL 3191
Proximity Label-MS Homo sapiens
74 ATP5B 506
Proximity Label-MS Homo sapiens
75 MRPS16  
Proximity Label-MS Homo sapiens
76 MRPL55  
Proximity Label-MS Homo sapiens
77 POLG  
Proximity Label-MS Homo sapiens
78 MRPL28 10573
Proximity Label-MS Homo sapiens
79 NDUFS6  
Proximity Label-MS Homo sapiens
80 AFG3L2 10939
Proximity Label-MS Homo sapiens
81 RBMXL1  
Proximity Label-MS Homo sapiens
82 MRPL48  
Proximity Label-MS Homo sapiens
83 ATP5J2-PTCD1  
Proximity Label-MS Homo sapiens
84 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 GTPBP10  
Proximity Label-MS Homo sapiens
86 RPA2 6118
Proximity Label-MS Homo sapiens
87 MTPAP 55149
Proximity Label-MS Homo sapiens
88 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 MRPL50 54534
Proximity Label-MS Homo sapiens
90 NDUFA4 4697
Affinity Capture-MS Homo sapiens
91 MRPL49 740
Proximity Label-MS Homo sapiens
92 C15orf48  
Affinity Capture-MS Homo sapiens
93 FFAR1  
Affinity Capture-MS Homo sapiens
94 NDUFS2 4720
Proximity Label-MS Homo sapiens
95 ATP5L 10632
Proximity Label-MS Homo sapiens
96 FIS1 51024
Affinity Capture-MS Homo sapiens
97 OGDH 4967
Proximity Label-MS Homo sapiens
98 COQ9  
Affinity Capture-MS Homo sapiens
99 AK3 50808
Proximity Label-MS Homo sapiens
100 CMTM4  
Two-hybrid Homo sapiens
101 WDR83  
Affinity Capture-MS Homo sapiens
102 MRPS23 51649
Proximity Label-MS Homo sapiens
103 NDUFA5 4698
Proximity Label-MS Homo sapiens
104 HIBCH 26275
Proximity Label-MS Homo sapiens
105 KHDRBS1 10657
Proximity Label-MS Homo sapiens
106 IBA57  
Proximity Label-MS Homo sapiens
107 MALSU1  
Proximity Label-MS Homo sapiens
108 ERAL1  
Proximity Label-MS Homo sapiens
109 ITFG3 83986
Affinity Capture-MS Homo sapiens
110 NDUFV3 4731
Proximity Label-MS Homo sapiens
111 MRPS7 51081
Proximity Label-MS Homo sapiens
112 SSBP1 6742
Proximity Label-MS Homo sapiens
113 TACO1  
Proximity Label-MS Homo sapiens
114 FASTKD2  
Proximity Label-MS Homo sapiens
115 PDPR 55066
Proximity Label-MS Homo sapiens
116 NNT 23530
Proximity Label-MS Homo sapiens
117 PRB3  
Two-hybrid Homo sapiens
118 MRPL45 84311
Proximity Label-MS Homo sapiens
119 CDR2L  
Two-hybrid Homo sapiens
120 AMACR 23600
Affinity Capture-MS Homo sapiens
121 SLC39A9 55334
Affinity Capture-MS Homo sapiens
122 ATPAF1  
Proximity Label-MS Homo sapiens
123 AGTRAP 57085
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
124 TMEM43 79188
Affinity Capture-MS Homo sapiens
125 MRPL51 51258
Proximity Label-MS Homo sapiens
126 PDHX 8050
Proximity Label-MS Homo sapiens
127 RAP1A 5906
Affinity Capture-MS Homo sapiens
128 POLDIP2 26073
Proximity Label-MS Homo sapiens
129 NDUFA2 4695
Proximity Label-MS Homo sapiens
130 MRPL3  
Proximity Label-MS Homo sapiens
131 AARS2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
132 MRPL39 54148
Proximity Label-MS Homo sapiens
133 ABCB7 22
Proximity Label-MS Homo sapiens
134 NDUFV1 4723
Proximity Label-MS Homo sapiens
135 CISD3 284106
Affinity Capture-MS Homo sapiens
136 MRPL44  
Proximity Label-MS Homo sapiens
137 ACOT1 641371
Proximity Label-MS Homo sapiens
138 CXCR4 7852
Affinity Capture-MS Homo sapiens
139 DHX36 170506
Proximity Label-MS Homo sapiens
140 MRPS35 60488
Proximity Label-MS Homo sapiens
141 CD83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 MRPS11  
Proximity Label-MS Homo sapiens
143 RTN4IP1  
Proximity Label-MS Homo sapiens
144 MRPL9 65005
Proximity Label-MS Homo sapiens
145 ATP5F1 515
Proximity Label-MS Homo sapiens
146 EGFR 1956
Affinity Capture-MS Homo sapiens
147 HSD17B10 3028
Proximity Label-MS Homo sapiens
148 GPRASP2  
Two-hybrid Homo sapiens
149 CMTM5  
Two-hybrid Homo sapiens
150 HNRNPAB 3182
Proximity Label-MS Homo sapiens
151 DDRGK1 65992
Affinity Capture-MS Homo sapiens
152 MRPS17 51373
Proximity Label-MS Homo sapiens
153 NDUFV2 4729
Proximity Label-MS Homo sapiens
154 LMNA 4000
Proximity Label-MS Homo sapiens
155 MCUR1 63933
Proximity Label-MS Homo sapiens
156 PPIF 10105
Proximity Label-MS Homo sapiens
157 TMEM239  
Two-hybrid Homo sapiens
158 CLPP 8192
Proximity Label-MS Homo sapiens
159 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
160 C17orf80 55028
Proximity Label-MS Homo sapiens
161 TMEM9 252839
Affinity Capture-MS Homo sapiens
162 ILF3 3609
Proximity Label-MS Homo sapiens
163 WARS2  
Proximity Label-MS Homo sapiens
164 MAL2 114569
Two-hybrid Homo sapiens
165 TRMT61B  
Proximity Label-MS Homo sapiens
166 SQSTM1 8878
Proximity Label-MS Homo sapiens
167 COX8A  
Proximity Label-MS Homo sapiens
168 SHMT2 6472
Proximity Label-MS Homo sapiens
169 MRPS21  
Proximity Label-MS Homo sapiens
170 PGAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 ME2 4200
Proximity Label-MS Homo sapiens
172 GFM1 85476
Proximity Label-MS Homo sapiens
173 TIMM44 10469
Proximity Label-MS Homo sapiens
174 QRSL1  
Proximity Label-MS Homo sapiens
175 MRPS9 64965
Proximity Label-MS Homo sapiens
176 MRPS27 23107
Proximity Label-MS Homo sapiens
177 SLIRP 81892
Proximity Label-MS Homo sapiens
178 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 NDUFS1 4719
Proximity Label-MS Homo sapiens
180 MRPL30  
Proximity Label-MS Homo sapiens
181 MRPL17  
Proximity Label-MS Homo sapiens
182 ANGEL2 90806
Proximity Label-MS Homo sapiens
183 FAM9B  
Two-hybrid Homo sapiens
184 IGHM 3507
Affinity Capture-MS Homo sapiens
185 ISCA1  
Proximity Label-MS Homo sapiens
186 PYCR1 5831
Proximity Label-MS Homo sapiens
187 GATB  
Proximity Label-MS Homo sapiens
188 CARS2 79587
Proximity Label-MS Homo sapiens
189 LRPPRC 10128
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
190 ACAD9 28976
Proximity Label-MS Homo sapiens
191 NDUFS3 4722
Proximity Label-MS Homo sapiens
192 MCM2 4171
Affinity Capture-MS Homo sapiens
193 SDHB 6390
Proximity Label-MS Homo sapiens
194 IGSF8 93185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
195 TIMMDC1  
Affinity Capture-MS Homo sapiens
196 YARS2  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
197 HINT2 84681
Proximity Label-MS Homo sapiens
198 CALCOCO2  
Two-hybrid Homo sapiens
199 CCDC47 57003
Affinity Capture-MS Homo sapiens
200 NDUFAF1  
Proximity Label-MS Homo sapiens
201 MRPL4 51073
Proximity Label-MS Homo sapiens
202 MAS1  
Affinity Capture-MS Homo sapiens
203 MDH2 4191
Proximity Label-MS Homo sapiens
204 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 ALAS1  
Proximity Label-MS Homo sapiens
206 EIF2AK2 5610
Proximity Label-MS Homo sapiens
207 MRPS25 64432
Proximity Label-MS Homo sapiens
208 THEM4  
Proximity Label-MS Homo sapiens
209 FASTKD5  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
210 ALDH5A1 7915
Proximity Label-MS Homo sapiens
211 PARK2  
Affinity Capture-MS Homo sapiens
212 PAM16  
Proximity Label-MS Homo sapiens
213 NDUFAF5  
Proximity Label-MS Homo sapiens
214 TRMT11 60487
Proximity Label-MS Homo sapiens
215 NTRK1 4914
Affinity Capture-MS Homo sapiens
216 FRRS1L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
217 GPR182  
Affinity Capture-MS Homo sapiens
218 KIAA0391  
Proximity Label-MS Homo sapiens
219 PPA2 27068
Proximity Label-MS Homo sapiens
220 NARS2  
Proximity Label-MS Homo sapiens
221 HNRNPA3 220988
Proximity Label-MS Homo sapiens
222 ALDH2 217
Proximity Label-MS Homo sapiens
223 MRPL2 51069
Proximity Label-MS Homo sapiens
224 ASAP2 8853
Affinity Capture-MS Homo sapiens
225 HNRNPDL 9987
Proximity Label-MS Homo sapiens
226 ACAT1 38
Proximity Label-MS Homo sapiens
227 MRPL40 64976
Proximity Label-MS Homo sapiens
228 EFNA4  
Affinity Capture-MS Homo sapiens
229 TRMT10C 54931
Proximity Label-MS Homo sapiens
230 PNPT1 87178
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
231 MRPL10 124995
Proximity Label-MS Homo sapiens
232 MRPS14  
Proximity Label-MS Homo sapiens
233 NR3C1 2908
Proximity Label-MS Homo sapiens
234 DHX30 22907
Proximity Label-MS Homo sapiens
235 HNRNPUL1 11100
Proximity Label-MS Homo sapiens
236 MRPS28  
Proximity Label-MS Homo sapiens
237 CD27  
Affinity Capture-MS Homo sapiens
238 MRPL19 9801
Proximity Label-MS Homo sapiens
239 FAM134C 162427
Two-hybrid Homo sapiens