Gene description for ANGEL2
Gene name angel homolog 2 (Drosophila)
Gene symbol ANGEL2
Other names/aliases Ccr4d
KIAA0759L
Species Homo sapiens
 Database cross references - ANGEL2
ExoCarta ExoCarta_90806
Vesiclepedia VP_90806
Entrez Gene 90806
HGNC 30534
UniProt Q5VTE6  
 ANGEL2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ANGEL2
Molecular Function
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 IDA
    catalytic activity GO:0003824 IEA
Biological Process
    negative regulation of mitotic cell cycle GO:0045930 IMP
    3'-UTR-mediated mRNA stabilization GO:0070935 IBA
    3'-UTR-mediated mRNA stabilization GO:0070935 IMP
    mitochondrial mRNA 3'-end processing GO:0090616 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrial matrix GO:0005759 IDA
    Cajal body GO:0015030 IDA
 Experiment description of studies that identified ANGEL2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ANGEL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCL3  
Affinity Capture-MS Homo sapiens
2 CLPP 8192
Proximity Label-MS Homo sapiens
3 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
4 CIRBP 1153
Affinity Capture-MS Homo sapiens
5 PMPCB 9512
Proximity Label-MS Homo sapiens
6 MRPS26 64949
Proximity Label-MS Homo sapiens
7 AUH 549
Proximity Label-MS Homo sapiens
8 ILF3 3609
Affinity Capture-MS Homo sapiens
9 MRPL11 65003
Proximity Label-MS Homo sapiens
10 MTERF3  
Proximity Label-MS Homo sapiens
11 GAR1 54433
Affinity Capture-MS Homo sapiens
12 RPS2 6187
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ICT1 3396
Proximity Label-MS Homo sapiens
14 PRMT1 3276
Affinity Capture-MS Homo sapiens
15 NAA40  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MRPL38  
Affinity Capture-MS Homo sapiens
17 CAMK2A 815
Affinity Capture-MS Homo sapiens
18 TRUB2  
Proximity Label-MS Homo sapiens
19 PRMT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PDHA1 5160
Proximity Label-MS Homo sapiens
21 C6orf203  
Proximity Label-MS Homo sapiens
22 WBSCR16  
Proximity Label-MS Homo sapiens
23 METTL15  
Proximity Label-MS Homo sapiens
24 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
25 MDH2 4191
Proximity Label-MS Homo sapiens
26 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
27 MAMDC4  
Affinity Capture-MS Homo sapiens
28 C21orf33  
Proximity Label-MS Homo sapiens
29 RBM4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MTRF1  
Proximity Label-MS Homo sapiens
31 SSBP1 6742
Proximity Label-MS Homo sapiens
32 TUFM 7284
Proximity Label-MS Homo sapiens
33 MTIF3  
Proximity Label-MS Homo sapiens
34 KRTAP19-7  
Affinity Capture-MS Homo sapiens
35 C1QBP 708
Proximity Label-MS Homo sapiens
36 GFM1 85476
Proximity Label-MS Homo sapiens
37 RPUSD4 84881
Proximity Label-MS Homo sapiens
38 AARS2  
Proximity Label-MS Homo sapiens
39 HECW2  
Affinity Capture-MS Homo sapiens
40 EEF1D 1936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
42 PMPCA 23203
Proximity Label-MS Homo sapiens
43 COX8A  
Proximity Label-MS Homo sapiens
44 TSFM 10102
Proximity Label-MS Homo sapiens
45 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 HNRNPF 3185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TBRG4 9238
Proximity Label-MS Homo sapiens
48 ACAD9 28976
Proximity Label-MS Homo sapiens
49 HNRNPU 3192
Affinity Capture-MS Homo sapiens
50 KRTAP6-1  
Affinity Capture-MS Homo sapiens
51 POU5F1  
Affinity Capture-MS Homo sapiens
52 KRTAP13-3  
Affinity Capture-MS Homo sapiens
53 AMPD2 271
Affinity Capture-MS Homo sapiens
54 ZFC3H1 196441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 KRTAP13-2  
Affinity Capture-MS Homo sapiens
56 NANOG  
Affinity Capture-MS Homo sapiens
57 TFAM 7019
Proximity Label-MS Homo sapiens
58 DCP2  
Affinity Capture-MS Homo sapiens
59 FAM136A 84908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 LRP8 7804
Affinity Capture-MS Homo sapiens
61 FAM98B 283742
Affinity Capture-MS Homo sapiens
62 BCOR  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ANGEL2 is involved
No pathways found





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