Gene description for GFM1
Gene name G elongation factor, mitochondrial 1
Gene symbol GFM1
Other names/aliases COXPD1
EFG
EFG1
EFGM
EGF1
GFM
hEFG1
Species Homo sapiens
 Database cross references - GFM1
ExoCarta ExoCarta_85476
Entrez Gene 85476
HGNC 13780
MIM 606639
UniProt Q96RP9  
 GFM1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for GFM1
Molecular Function
    GTPase activity GO:0003924 IDA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
    translation elongation factor activity GO:0003746 IDA
Biological Process
    mitochondrial translational elongation GO:0070125 TAS
    mitochondrial translation GO:0032543 TAS
    organelle organization GO:0006996 TAS
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified GFM1 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GFM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VARS2  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which GFM1 is involved
PathwayEvidenceSource
Mitochondrial translation elongation TAS Reactome





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