Gene description for ALDH2
Gene name aldehyde dehydrogenase 2 family (mitochondrial)
Gene symbol ALDH2
Other names/aliases ALDH-E2
ALDHI
ALDM
Species Homo sapiens
 Database cross references - ALDH2
ExoCarta ExoCarta_217
Entrez Gene 217
HGNC 404
MIM 100650
UniProt P05091  
 ALDH2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Urine 19056867    
 Gene ontology annotations for ALDH2
Molecular Function
    aldehyde dehydrogenase (NAD) activity GO:0004029 IDA
    aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 TAS
    electron carrier activity GO:0009055 TAS
Biological Process
    alcohol metabolic process GO:0006066 TAS
    carbohydrate metabolic process GO:0005975 TAS
    small molecule metabolic process GO:0044281 TAS
    ethanol oxidation GO:0006069 TAS
    synaptic transmission GO:0007268 TAS
    ethanol catabolic process GO:0006068 IEA
    neurotransmitter biosynthetic process GO:0042136 TAS
    xenobiotic metabolic process GO:0006805 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified ALDH2 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ALDH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPE1 3336
Two-hybrid Homo sapiens
2 ALDH2 217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 HSPD1 3329
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
4 MGC15730  
Two-hybrid Homo sapiens
5 UNC119  
Two-hybrid Homo sapiens
6 SLC35F6 54978
Two-hybrid Homo sapiens
7 C14orf1 11161
Two-hybrid Homo sapiens
8 EIF6 3692
Two-hybrid Homo sapiens
9 CRMP1 1400
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ALDH2 is involved
PathwayEvidenceSource
Ethanol oxidation TAS Reactome
Metabolism of serotonin TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here