Gene description for HEXA
Gene name hexosaminidase A (alpha polypeptide)
Gene symbol HEXA
Other names/aliases TSD
Species Homo sapiens
 Database cross references - HEXA
ExoCarta ExoCarta_3073
Entrez Gene 3073
HGNC 4878
MIM 606869
UniProt P06865  
 HEXA identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for HEXA
Molecular Function
    protein heterodimerization activity GO:0046982 IDA
    beta-N-acetylhexosaminidase activity GO:0004563 IEA
Biological Process
    keratan sulfate metabolic process GO:0042339 TAS
    glycosphingolipid metabolic process GO:0006687 TAS
    sphingolipid metabolic process GO:0006665 TAS
    hyaluronan metabolic process GO:0030212 TAS
    keratan sulfate catabolic process GO:0042340 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    chondroitin sulfate metabolic process GO:0030204 TAS
    hyaluronan catabolic process GO:0030214 TAS
    chondroitin sulfate catabolic process GO:0030207 TAS
    small molecule metabolic process GO:0044281 TAS
    carbohydrate metabolic process GO:0005975 TAS
Subcellular Localization
    lysosomal lumen GO:0043202 TAS
    extracellular exosome GO:0070062 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified HEXA in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HEXA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GM2A 2760
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
2 USP22 23326
Two-hybrid Homo sapiens
View the network image/svg+xml



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