ExoCarta: Gene summary

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Gene description for GTF3C4
Gene name	general transcription factor IIIC, polypeptide 4, 90kDa
Gene symbol	GTF3C4
Other names/aliases	KAT12 TFIII90 TFIIIC290 TFIIIC90 TFIIICDELTA
Species	Homo sapiens
Database cross references - GTF3C4
ExoCarta	ExoCarta_9329
Vesiclepedia	VP_9329
Entrez Gene	9329
HGNC	4667
MIM	604892
UniProt	Q9UKN8
GTF3C4 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	34887515

Gene ontology annotations for GTF3C4

Molecular Function
	histone acetyltransferase activity	GO:0004402	IEA
	protein binding	GO:0005515	IPI
	enzyme activator activity	GO:0008047	TAS
	DNA binding	GO:0003677	IC
Biological Process
	transcription from RNA polymerase III promoter	GO:0006383	TAS
	5S class rRNA transcription from RNA polymerase III type 1 promoter	GO:0042791	IC
	histone acetylation	GO:0016573	TAS
	positive regulation of catalytic activity	GO:0043085	TAS
	transcription initiation from RNA polymerase III promoter	GO:0006384	TAS
	transcription, DNA-templated	GO:0006351	IC
	gene expression	GO:0010467	TAS
	tRNA transcription from RNA polymerase III promoter	GO:0042797	IC
Subcellular Localization
	nucleoplasm	GO:0005654	TAS
	transcription factor TFIIIC complex	GO:0000127	IDA

Experiment description of studies that identified GTF3C4 in exosomes

Experiment ID

1203

MISEV standards
✔ EM	EV Biophysical techniques
✔ SDCBP\|FLOT1\|CD9\|CD81\|CD63\|EPCAM\|GAPDH\|LAMP1\|TFRC\|CD151\|CD82\|LAMP2\|RAB35\|TSG101\|FLOT2\|RAB5B\|ICAM1\|RAB5A	EV Enriched markers
✘	EV Negative markers
✘	EV Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

34887515

Organism

Homo sapiens

Experiment description

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Authors

Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.

Journal name

Nat Cell Biol

Publication year

2021

Sample

Colorectal cancer cells

Sample name

DiFi

Isolation/purification methods

Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation

Flotation density

Molecules identified in the study

Protein
miRNA

Methods used in the study

Western blotting
Mass spectrometry
RNA sequencing

Protein-protein interactions for GTF3C4

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

HIST2H3A

333932

Reconstituted Complex

Homo sapiens

POLR3C

10623

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

TBP

Reconstituted Complex

Homo sapiens

GTF3C1

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

POLR3F

Reconstituted Complex

Homo sapiens

GTF3C3

9330

Affinity Capture-Western

Homo sapiens

GTF3C5

9328

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

GTF3C2

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

View the network

Pathways in which GTF3C4 is involved

Pathway	Evidence	Source
RNA Polymerase III Abortive And Retractive Initiation	TAS	Reactome
RNA Polymerase III Transcription Initiation From Type 1 Promoter	TAS	Reactome
RNA Polymerase III Transcription Initiation From Type 2 Promoter	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here