Gene description for CBX8
Gene name chromobox homolog 8
Gene symbol CBX8
Other names/aliases PC3
RC1
Species Homo sapiens
 Database cross references - CBX8
ExoCarta ExoCarta_57332
Vesiclepedia VP_57332
Entrez Gene 57332
HGNC 15962
UniProt Q9HC52  
 CBX8 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for CBX8
Molecular Function
    protein binding GO:0005515 IPI
    single-stranded RNA binding GO:0003727 IEA
    ubiquitin-protein transferase activity GO:0004842 IEA
    methylated histone binding GO:0035064 IDA
Biological Process
    protein sumoylation GO:0016925 TAS
    histone ubiquitination GO:0016574 IEA
    cellular protein metabolic process GO:0044267 TAS
    post-translational protein modification GO:0043687 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nuclear chromatin GO:0000790 IDA
    PcG protein complex GO:0031519 IDA
    heterochromatin GO:0000792 IEA
    nucleus GO:0005634 IDA
    PRC1 complex GO:0035102 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified CBX8 in exosomes
1
Experiment ID 193
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|CD9
EV Enriched markers
✔
PHB
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CBX8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RING1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 Bmi1  
Affinity Capture-MS Mus musculus
3 MYST2  
Two-hybrid Homo sapiens
4 UNC119 9094
Two-hybrid Homo sapiens
5 HAP1  
Two-hybrid Homo sapiens
6 HTATIP  
Two-hybrid Homo sapiens
7 MLLT1 4298
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 EEF1G 1937
Two-hybrid Homo sapiens
9 SETDB1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CBX8 is involved
PathwayEvidenceSource
Oxidative Stress Induced Senescence TAS Reactome
SUMOylation of DNA damage response and repair proteins TAS Reactome





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