Gene description for CBX8
Gene name chromobox homolog 8
Gene symbol CBX8
Other names/aliases PC3
RC1
Species Homo sapiens
 Database cross references - CBX8
ExoCarta ExoCarta_57332
Vesiclepedia VP_57332
Entrez Gene 57332
HGNC 15962
UniProt Q9HC52  
 CBX8 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for CBX8
Molecular Function
    chromatin binding GO:0003682 IBA
    single-stranded RNA binding GO:0003727 IEA
    protein binding GO:0005515 IPI
    methylated histone binding GO:0035064 IBA
    methylated histone binding GO:0035064 IDA
    ubiquitin-protein transferase activator activity GO:0097027 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    chromatin organization GO:0006325 IEA
    positive regulation of cell population proliferation GO:0008284 IEA
    positive regulation of collagen biosynthetic process GO:0032967 IEA
    positive regulation of DNA repair GO:0045739 IEA
    cellular response to hydrogen peroxide GO:0070301 IEA
Subcellular Localization
    chromatin GO:0000785 IBA
    chromatin GO:0000785 IDA
    heterochromatin GO:0000792 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    PcG protein complex GO:0031519 IDA
    PRC1 complex GO:0035102 IBA
    PRC1 complex GO:0035102 IDA
 Experiment description of studies that identified CBX8 in exosomes
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CBX8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDC14B 8555
Proximity Label-MS Homo sapiens
2 PIH1D2  
Two-hybrid Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 H2AFJ 55766
Affinity Capture-MS Homo sapiens
5 HMGN5 79366
Affinity Capture-MS Homo sapiens
6 PCGF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CENPB 1059
Affinity Capture-MS Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 PAXIP1  
Two-hybrid Homo sapiens
10 RPS3A 6189
Affinity Capture-MS Homo sapiens
11 KIFC3 3801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 GPRASP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 RPS14 6208
Affinity Capture-MS Homo sapiens
14 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
15 Cbx7  
Affinity Capture-MS Mus musculus
16 MDFI  
Two-hybrid Homo sapiens
17 TRIM27  
Two-hybrid Homo sapiens
18 PLEKHF2 79666
Two-hybrid Homo sapiens
19 TTC23  
Two-hybrid Homo sapiens
20 DVL3 1857
Two-hybrid Homo sapiens
21 FBRS 64319
Affinity Capture-MS Homo sapiens
22 SETDB1  
Two-hybrid Homo sapiens
23 TRIM54  
Two-hybrid Homo sapiens
24 CENPA  
Co-purification Homo sapiens
25 PCGF2 7703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
26 APEX1 328
Proximity Label-MS Homo sapiens
27 KAT7  
Two-hybrid Homo sapiens
28 RPS20 6224
Affinity Capture-MS Homo sapiens
29 TSC22D4 81628
Two-hybrid Homo sapiens
30 JAKMIP1 152789
Two-hybrid Homo sapiens
31 CEP70  
Two-hybrid Homo sapiens
32 Mllt1  
Affinity Capture-MS Mus musculus
33 H1FX 8971
Affinity Capture-MS Homo sapiens
34 USH1G  
Two-hybrid Homo sapiens
35 PHC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 E2F6 1876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 FBXW7  
Affinity Capture-MS Homo sapiens
38 KRT40  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 RPS8 6202
Affinity Capture-MS Homo sapiens
40 CALCOCO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 BMI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 MTUS2 23281
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
43 CRCP  
Affinity Capture-MS Homo sapiens
44 FKBP11 51303
Affinity Capture-MS Homo sapiens
45 BCORL1  
Affinity Capture-MS Homo sapiens
46 Cbx4  
Affinity Capture-MS Mus musculus
47 BRD4 23476
Affinity Capture-MS Homo sapiens
48 EEF1G 1937
Two-hybrid Homo sapiens
49 ZBTB14  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 MECP2 4204
Affinity Capture-MS Homo sapiens
51 FSD2 123722
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 TFCP2 7024
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
53 MYCN  
Affinity Capture-MS Homo sapiens
54 MLLT1 4298
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
55 USP7 7874
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
56 CSNK2B 1460
Affinity Capture-MS Homo sapiens
57 SOX5 6660
Two-hybrid Homo sapiens
58 DDX54 79039
Affinity Capture-MS Homo sapiens
59 KIF14 9928
Affinity Capture-MS Homo sapiens
60 PCGF3  
Affinity Capture-MS Homo sapiens
61 CHST12 55501
Affinity Capture-MS Homo sapiens
62 LSM2 57819
Two-hybrid Homo sapiens
63 GOLGA6L9  
Two-hybrid Homo sapiens
64 BANP  
Two-hybrid Homo sapiens
65 KRT34  
Two-hybrid Homo sapiens
66 C10orf12  
Affinity Capture-MS Homo sapiens
67 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
68 MCC 4163
Two-hybrid Homo sapiens
69 FHL3 2275
Two-hybrid Homo sapiens
70 USP11 8237
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
71 ICE1  
Affinity Capture-MS Homo sapiens
72 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
73 CBX3 11335
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 Ring1  
Affinity Capture-MS Mus musculus
75 RPL18A 6142
Affinity Capture-MS Homo sapiens
76 MB21D2  
Two-hybrid Homo sapiens
77 MID2 11043
Two-hybrid Homo sapiens
78 CARD9 64170
Two-hybrid Homo sapiens
79 EXOSC4 54512
Affinity Capture-MS Homo sapiens
80 SCML2  
Affinity Capture-MS Homo sapiens
81 PNMA2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
82 CBX6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 UNC119 9094
Two-hybrid Homo sapiens
84 Hnrnpf 98758
Affinity Capture-MS Mus musculus
85 RPL36 25873
Affinity Capture-MS Homo sapiens
86 HECTD1 25831
Affinity Capture-MS Homo sapiens
87 EED  
Affinity Capture-MS Homo sapiens
88 PRKAR1B  
Two-hybrid Homo sapiens
89 RYBP  
Affinity Capture-MS Homo sapiens
90 BCOR  
Affinity Capture-MS Homo sapiens
91 RSL1D1 26156
Affinity Capture-MS Homo sapiens
92 RING1 6015
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
93 HAP1  
Two-hybrid Homo sapiens
94 NUMA1 4926
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 KMT2A  
Affinity Capture-Western Homo sapiens
96 TAX1BP1 8887
Two-hybrid Homo sapiens
97 KANK2 25959
Two-hybrid Homo sapiens
98 KCTD9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 ZNF185 7739
Two-hybrid Homo sapiens
100 MGA  
Affinity Capture-MS Homo sapiens
101 CCDC57 284001
Two-hybrid Homo sapiens
102 YAF2  
Affinity Capture-MS Homo sapiens
103 RPGRIP1  
Two-hybrid Homo sapiens
104 H1F0 3005
Affinity Capture-MS Homo sapiens
105 HMBOX1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
106 CBX2  
Affinity Capture-MS Homo sapiens
107 SUZ12  
Affinity Capture-MS Homo sapiens
108 HIST3H3 8290
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
109 LZTS2 84445
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
110 BAZ2A  
Affinity Capture-MS Homo sapiens
111 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
112 PHACTR1 221692
Two-hybrid Homo sapiens
113 RPL10 6134
Affinity Capture-MS Homo sapiens
114 MYC  
Affinity Capture-MS Homo sapiens
115 DYNC1LI1 51143
Proximity Label-MS Homo sapiens
116 GIGYF1  
Two-hybrid Homo sapiens
117 RPS4Y1 6192
Affinity Capture-MS Homo sapiens
118 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
119 PHC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 TOP1 7150
Affinity Capture-MS Homo sapiens
121 KAT5  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
122 RPL22 6146
Affinity Capture-MS Homo sapiens
123 Bmi1  
Affinity Capture-MS Mus musculus
124 PCGF1 84759
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 SESTD1 91404
Two-hybrid Homo sapiens
126 RNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 IKZF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
128 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
129 H2BFS  
Affinity Capture-MS Homo sapiens
130 SCMH1  
Affinity Capture-MS Homo sapiens
131 ENTHD2  
Two-hybrid Homo sapiens
132 FTSJ3 117246
Affinity Capture-MS Homo sapiens
133 KDM2B 84678
Affinity Capture-MS Homo sapiens
134 TSGA10  
Two-hybrid Homo sapiens
135 BACH2 60468
Two-hybrid Homo sapiens
136 CBX4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 RASSF3 283349
Two-hybrid Homo sapiens
138 TRAF2 7186
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
139 PARP1 142
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 HOMEZ  
Two-hybrid Homo sapiens
141 ZBTB8A  
Two-hybrid Homo sapiens
142 FXR1 8087
Two-hybrid Homo sapiens
143 POLR1C 9533
Two-hybrid Homo sapiens
144 PSMB7 5695
Affinity Capture-MS Homo sapiens
145 RPS12 6206
Affinity Capture-MS Homo sapiens
146 SKP1 6500
Affinity Capture-MS Homo sapiens
147 PNMA1 9240
Two-hybrid Homo sapiens
148 ABLIM3 22885
Two-hybrid Homo sapiens
149 SFTPC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 GTF3C4 9329
Affinity Capture-MS Homo sapiens
151 TRIM23 373
Two-hybrid Homo sapiens
152 NAB2 4665
Two-hybrid Homo sapiens
153 ZBTB9  
Two-hybrid Homo sapiens
154 PCGF6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 RPL7A 6130
Affinity Capture-MS Homo sapiens
156 CBX8 57332
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
157 RPS6 6194
Affinity Capture-MS Homo sapiens
158 TRIB3  
Two-hybrid Homo sapiens
159 TXNIP 10628
Two-hybrid Homo sapiens
160 CMSS1  
Affinity Capture-MS Homo sapiens
161 HNRNPU 3192
Affinity Capture-MS Homo sapiens
162 CCDC136  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
163 PHC2  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 HSF2BP  
Two-hybrid Homo sapiens
165 ESCO1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CBX8 is involved
PathwayEvidenceSource
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intracellular signaling by second messengers TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Oxidative Stress Induced Senescence TAS Reactome
PIP3 activates AKT signaling IEA Reactome
PIP3 activates AKT signaling TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
PTEN Regulation IEA Reactome
PTEN Regulation TAS Reactome
Regulation of PTEN gene transcription IEA Reactome
Regulation of PTEN gene transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMOylation TAS Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins TAS Reactome
SUMOylation of DNA damage response and repair proteins TAS Reactome
SUMOylation of DNA methylation proteins IEA Reactome
SUMOylation of RNA binding proteins TAS Reactome
SUMOylation of transcription cofactors TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome





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