Gene description for KDM2B
Gene name lysine (K)-specific demethylase 2B
Gene symbol KDM2B
Other names/aliases CXXC2
FBXL10
Fbl10
JHDM1B
PCCX2
Species Homo sapiens
 Database cross references - KDM2B
ExoCarta ExoCarta_84678
Entrez Gene 84678
HGNC 13610
MIM 609078
UniProt Q8NHM5  
 KDM2B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for KDM2B
Molecular Function
    DNA binding GO:0003677 NAS
    rRNA binding GO:0019843 IEA
    histone demethylase activity (H3-K36 specific) GO:0051864 IEA
    histone demethylase activity GO:0032452 TAS
    zinc ion binding GO:0008270 IEA
    protein binding GO:0005515 IPI
Biological Process
    initiation of neural tube closure GO:0021993 ISS
    embryonic camera-type eye morphogenesis GO:0048596 ISS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    spermatogenesis GO:0007283 ISS
    histone demethylation GO:0016577 TAS
    lateral ventricle development GO:0021670 ISS
    histone H3-K36 demethylation GO:0070544 IEA
    forebrain development GO:0030900 ISS
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    histone H2A monoubiquitination GO:0035518 IDA
    third ventricle development GO:0021678 ISS
    chromatin organization GO:0006325 TAS
    fourth ventricle development GO:0021592 ISS
    midbrain development GO:0030901 ISS
    hindbrain development GO:0030902 ISS
    negative regulation of neural precursor cell proliferation GO:2000178 ISS
    oxidation-reduction process GO:0055114 IEA
    midbrain-hindbrain boundary morphogenesis GO:0021555 ISS
Subcellular Localization
    PcG protein complex GO:0031519 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IEA
    nucleus GO:0005634 NAS
 Experiment description of studies that identified KDM2B in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KDM2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KDM2B is involved
PathwayEvidenceSource
HDMs demethylate histones TAS Reactome





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