Gene description for HIST2H3C
Gene name histone cluster 2, H3c
Gene symbol HIST2H3C
Other names/aliases H3
H3.2
H3/M
H3F2
H3FM
H3FN
Species Homo sapiens
 Database cross references - HIST2H3C
ExoCarta ExoCarta_126961
Vesiclepedia VP_126961
Entrez Gene 126961
HGNC 20503
MIM 142780
UniProt Q71DI3  
 HIST2H3C identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Saliva 19199708    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for HIST2H3C
Molecular Function
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    chromatin organization GO:0006325 NAS
    nucleosome assembly GO:0006334 IDA
Subcellular Localization
    nucleosome GO:0000786 IDA
    nucleosome GO:0000786 IPI
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HIST2H3C in sEVs
1
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
8
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
9
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
10
Experiment ID 144
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
11
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
12
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
13
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HIST2H3C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
2 RPS6KA5 9252
Biochemical Activity Homo sapiens
3 NCOA6  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 KMT2C 58508
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
5 Kdm4B  
Biochemical Activity Drosophila melanogaster
6 UBE2A  
Affinity Capture-MS Homo sapiens
7 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
8 RIT1 6016
Negative Genetic Homo sapiens
9 BRCA1 672
Co-localization Homo sapiens
10 PRMT6  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
11 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
12 KDM6A  
Biochemical Activity Homo sapiens
13 IFNGR1 3459
Affinity Capture-Western Homo sapiens
14 INCENP 3619
Reconstituted Complex Homo sapiens
15 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
16 WDR76  
Affinity Capture-MS Homo sapiens
17 CHAF1A  
Affinity Capture-Western Homo sapiens
18 MCM2 4171
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
19 KDM2A  
Biochemical Activity Homo sapiens
20 XIST  
Co-localization Homo sapiens
21 Whsc1  
Biochemical Activity Mus musculus
22 KMT2D 8085
Biochemical Activity Homo sapiens
23 POU5F1  
Affinity Capture-MS Homo sapiens
24 OBSL1 23363
Affinity Capture-MS Homo sapiens
25 SMC2 10592
Affinity Capture-Western Homo sapiens
26 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
27 ITGA4 3676
Affinity Capture-MS Homo sapiens
28 ATRX 546
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
29 MUM1  
Protein-peptide Homo sapiens
30 MSL2  
Biochemical Activity Homo sapiens
31 VCAM1 7412
Affinity Capture-MS Homo sapiens
32 NAP1L4 4676
Reconstituted Complex Homo sapiens
33 MECP2 4204
Co-crystal Structure Homo sapiens
34 SETD1A 9739
Biochemical Activity Homo sapiens
35 RMDN1 51115
Affinity Capture-MS Homo sapiens
36 MTA2 9219
Co-fractionation Homo sapiens
37 KDM3A  
Biochemical Activity Homo sapiens
38 H2AFZ 3015
Cross-Linking-MS (XL-MS) Homo sapiens
39 CXXC1  
Affinity Capture-Western Homo sapiens
40 ING4  
Co-crystal Structure Homo sapiens
41 RNF4 6047
Biochemical Activity Homo sapiens
42 WHSC1 7468
Protein-peptide Homo sapiens
43 DOT1L 84444
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 BAG6 7917
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
45 VRK1 7443
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
46 SMARCA4 6597
Protein-peptide Homo sapiens
47 CBX5 23468
Affinity Capture-MS Homo sapiens
48 RAD18  
Affinity Capture-MS Homo sapiens
49 PKN1 5585
Biochemical Activity Homo sapiens
50 YWHAQ 10971
Affinity Capture-Western Homo sapiens
51 MYH10 4628
Co-fractionation Homo sapiens
52 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
53 BRD4 23476
Reconstituted Complex Homo sapiens
54 H2AFY 9555
Affinity Capture-MS Homo sapiens
55 HIST1H2AB 8335
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
56 ARID4A  
Reconstituted Complex Homo sapiens
57 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
58 PARP3 10039
Affinity Capture-MS Homo sapiens
59 BRD7  
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
60 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
61 HIST1H2AD 3013
Cross-Linking-MS (XL-MS) Homo sapiens
62 HIST1H3A 8350
Affinity Capture-MS Homo sapiens
63 NASP 4678
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 RERE 473
Biochemical Activity Homo sapiens
65 HIST2H3C 126961
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
66 SMARCA5 8467
Co-fractionation Homo sapiens
67 CDCA8 55143
Reconstituted Complex Homo sapiens
68 JADE1  
Reconstituted Complex Homo sapiens
69 TAF1B  
Affinity Capture-Western Homo sapiens
70 ELP3 55140
Biochemical Activity Homo sapiens
71 PHF2  
Affinity Capture-Western Homo sapiens
72 DDB2  
Biochemical Activity Homo sapiens
73 SUZ12  
Affinity Capture-MS Homo sapiens
74 FN1 2335
Affinity Capture-MS Homo sapiens
75 HIST1H2BO 8348
Cross-Linking-MS (XL-MS) Homo sapiens
76 AURKB 9212
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
77 Kdm4A  
Biochemical Activity Drosophila melanogaster
78 STAT1 6772
Affinity Capture-Western Homo sapiens
79 HIST1H2AH 85235
Cross-Linking-MS (XL-MS) Homo sapiens
80 NRD1 4898
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
81 PHF21A  
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
82 EHMT2 10919
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
83 KAT5  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
84 TBL1X 6907
Reconstituted Complex Homo sapiens
85 KMT2A  
Biochemical Activity Homo sapiens
86 KAT6A  
Reconstituted Complex Homo sapiens
87 NANOG  
Affinity Capture-MS Homo sapiens
88 RBBP5 5929
Reconstituted Complex Homo sapiens
89 CHUK 1147
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
90 ATXN7L3  
Affinity Capture-MS Homo sapiens
91 BIRC5  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
92 H2AFX 3014
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
93 DNMT3L  
Reconstituted Complex Homo sapiens
94 SNCA 6622
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
95 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
96 KAT2A  
Biochemical Activity Homo sapiens
97 HIST1H2AC 8334
Cross-Linking-MS (XL-MS) Homo sapiens
98 H3F3A 3020
Affinity Capture-MS Homo sapiens
99 CDK8 1024
Biochemical Activity Homo sapiens
100 MTA1 9112
Affinity Capture-Western Homo sapiens
101 KMT2B  
Biochemical Activity Homo sapiens
102 KAT2B  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
103 PDHA1 5160
Affinity Capture-MS Homo sapiens
104 KDM4C  
Biochemical Activity Homo sapiens
105 PIM1  
Biochemical Activity Homo sapiens
106 RNF20 56254
Biochemical Activity Homo sapiens
107 EPB41L2 2037
Co-fractionation Homo sapiens
108 SETD1B 23067
Biochemical Activity Homo sapiens
109 PCNA 5111
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
110 HDGFRP2 84717
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
111 KDM1A 23028
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
112 ING1  
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
113 SMYD2 56950
Biochemical Activity Homo sapiens
114 BRPF1  
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
115 BRD1 23774
Protein-peptide Homo sapiens
116 HIRA  
Affinity Capture-Western Homo sapiens
117 CUL7 9820
Affinity Capture-MS Homo sapiens
118 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
119 UHRF1 29128
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
120 KDM2B 84678
Affinity Capture-MS Homo sapiens
121 CHAF1B  
Affinity Capture-Western Homo sapiens
122 JAK2 3717
Affinity Capture-Western Homo sapiens
123 WDHD1  
Affinity Capture-Western Homo sapiens
124 RANGAP1 5905
Co-fractionation Homo sapiens
125 EP300 2033
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which HIST2H3C is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization TAS Reactome
Chromatin organization IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Defective pyroptosis TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA methylation IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Factors involved in megakaryocyte development and platelet production TAS Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones TAS Reactome
HATs acetylate histones IEA Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HDACs deacetylate histones TAS Reactome
HDMs demethylate histones TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Interleukin-7 signaling TAS Reactome
Interleukin-7 signaling IEA Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Metabolism of proteins TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
NoRC negatively regulates rRNA expression IEA Reactome
NoRC negatively regulates rRNA expression TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
PKMTs methylate histone lysines TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RMTs methylate histone arginines TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Viral Infection Pathways TAS Reactome





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