Gene description for ATRX
Gene name alpha thalassemia/mental retardation syndrome X-linked
Gene symbol ATRX
Other names/aliases ATR2
JMS
MRXHF1
RAD54
RAD54L
SFM1
SHS
XH2
XNP
ZNF-HX
Species Homo sapiens
 Database cross references - ATRX
ExoCarta ExoCarta_546
Vesiclepedia VP_546
Entrez Gene 546
HGNC 886
MIM 300032
UniProt P46100  
 ATRX identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ATRX
Molecular Function
    DNA binding GO:0003677 IEA
    chromo shadow domain binding GO:0070087 IPI
    DNA translocase activity GO:0015616 IDA
    methylated histone binding GO:0035064 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    chromatin binding GO:0003682 IEA
    helicase activity GO:0004386 TAS
    zinc ion binding GO:0008270 IEA
    histone binding GO:0042393 IDA
    DNA helicase activity GO:0003678 TAS
Biological Process
    Sertoli cell development GO:0060009 IEA
    seminiferous tubule development GO:0072520 IEA
    DNA methylation GO:0006306 TAS
    chromatin remodeling GO:0006338 IDA
    nucleosome assembly GO:0006334 IDA
    spermatogenesis GO:0007283 IEA
    replication fork processing GO:0031297 ISS
    forebrain development GO:0030900 IEA
    DNA replication-independent nucleosome assembly GO:0006336 IMP
    DNA damage response, signal transduction by p53 class mediator GO:0030330 ISS
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    DNA duplex unwinding GO:0032508 TAS
    positive regulation of nuclear cell cycle DNA replication GO:0010571 ISS
    negative regulation of telomeric RNA transcription from RNA pol II promoter GO:1901581 ISS
    DNA recombination GO:0006310 TAS
    regulation of transcription, DNA-templated GO:0006355 TAS
    cellular response to hydroxyurea GO:0072711 ISS
    positive regulation of telomere maintenance GO:0032206 ISS
    DNA repair GO:0006281 IEA
Subcellular Localization
    telomeric heterochromatin GO:0031933 ISS
    nuclear heterochromatin GO:0005720 TAS
    PML body GO:0016605 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    SWI/SNF superfamily-type complex GO:0070603 IDA
 Experiment description of studies that identified ATRX in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ATRX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF4A2 1974
Affinity Capture-MS Homo sapiens
2 LUC7L2 51631
Two-hybrid Homo sapiens
3 PTN  
Two-hybrid Homo sapiens
4 CCSER2 54462
Two-hybrid Homo sapiens
5 PTPN4  
Two-hybrid Homo sapiens
6 EZH2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
7 RAD51  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
8 KIAA1377  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ATRX is involved
No pathways found





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