Gene description for WHSC1
Gene name	Wolf-Hirschhorn syndrome candidate 1
Gene symbol	WHSC1
Other names/aliases	MMSET NSD2 REIIBP TRX5 WHS
Species	Homo sapiens
Database cross references - WHSC1
ExoCarta	ExoCarta_7468
Vesiclepedia	VP_7468
Entrez Gene	7468
HGNC	12766
MIM	602952
UniProt	O96028
WHSC1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Urine	21595033
Urine	21595033
Urine	21595033

Gene ontology annotations for WHSC1

Molecular Function     chromatin binding GO:0003682 IEA     protein binding GO:0005515 IPI     histone H4K20 methyltransferase activity GO:0042799 TAS     sequence-specific DNA binding GO:0043565 IEA     metal ion binding GO:0046872 IEA     histone H3K36 methyltransferase activity GO:0046975 IBA     histone H3K36 methyltransferase activity GO:0046975 IMP     histone H3 methyltransferase activity GO:0140938 TAS     histone H3K36 dimethyltransferase activity GO:0140954 IEA     histone H3K36 trimethyltransferase activity GO:0140955 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     membranous septum morphogenesis GO:0003149 IEA     atrial septum primum morphogenesis GO:0003289 IEA     atrial septum secundum morphogenesis GO:0003290 IEA     double-strand break repair GO:0006302 TAS     chromatin remodeling GO:0006338 IEA     regulation of DNA-templated transcription GO:0006355 IBA     methylation GO:0032259 IEA     positive regulation of isotype switching to IgA isotypes GO:0048298 IEA     bone development GO:0060348 IEA     regulation of establishment of protein localization GO:0070201 IEA     regulation of double-strand break repair via nonhomologous end joining GO:2001032 IEA Subcellular Localization     chromatin GO:0000785 IBA     nucleus GO:0005634 IBA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     nucleolus GO:0005730 IEA     cytoplasm GO:0005737 IEA