Gene description for MYBBP1A
Gene name MYB binding protein (P160) 1a
Gene symbol MYBBP1A
Other names/aliases P160
PAP2
Species Homo sapiens
 Database cross references - MYBBP1A
ExoCarta ExoCarta_10514
Entrez Gene 10514
HGNC 7546
MIM 604885
UniProt Q9BQG0  
 MYBBP1A identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for MYBBP1A
Molecular Function
    protein binding GO:0005515 IPI
    transcription corepressor activity GO:0003714 ISS
    DNA-directed DNA polymerase activity GO:0003887 IEA
    transcription factor binding GO:0008134 TAS
    core promoter binding GO:0001047 ISS
    poly(A) RNA binding GO:0044822 IDA
    sequence-specific DNA binding GO:0043565 IEA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 TAS
    cellular response to glucose starvation GO:0042149 IDA
    DNA biosynthetic process GO:0071897 IEA
    positive regulation of anoikis GO:2000210 IMP
    osteoblast differentiation GO:0001649 IDA
    nucleocytoplasmic transport GO:0006913 ISS
    respiratory electron transport chain GO:0022904 IEA
    transcription, DNA-templated GO:0006351 IEA
    circadian regulation of gene expression GO:0032922 ISS
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IMP
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    positive regulation of cell cycle arrest GO:0071158 IMP
Subcellular Localization
    cytoplasm GO:0005737 ISS
    nucleolus GO:0005730 ISS
    intracellular membrane-bounded organelle GO:0043231 IDA
    NLS-dependent protein nuclear import complex GO:0042564 ISS
    nucleus GO:0005634 ISS
    membrane GO:0016020 IDA
 Experiment description of studies that identified MYBBP1A in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MYBBP1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PCNA 5111
Invitro Homo sapiens
2 LYAR 55646
Affinity Capture-MS Homo sapiens
3 AR 367
Invitro Homo sapiens
4 JUN 3725
Invitro Homo sapiens
5 MYB  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
6 MYC  
Affinity Capture-MS Homo sapiens
7 DDX56  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MYBBP1A is involved
No pathways found





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