Gene description for NOP9
Gene name NOP9 nucleolar protein
Gene symbol NOP9
Other names/aliases C14orf21
Species Homo sapiens
 Database cross references - NOP9
ExoCarta ExoCarta_161424
Vesiclepedia VP_161424
Entrez Gene 161424
HGNC 19826
UniProt Q86U38  
 NOP9 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for NOP9
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
Biological Process
    ribosomal small subunit export from nucleus GO:0000056 IBA
    endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000447 IBA
    endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000472 IBA
    endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000480 IBA
    biological_process GO:0008150 ND
Subcellular Localization
    cellular_component GO:0005575 ND
    nucleolus GO:0005730 IBA
    90S preribosome GO:0030686 IBA
    preribosome, small subunit precursor GO:0030688 IBA
 Experiment description of studies that identified NOP9 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NOP9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CENPB 1059
Affinity Capture-MS Homo sapiens
2 ZNF668  
Affinity Capture-MS Homo sapiens
3 PAXIP1  
Affinity Capture-MS Homo sapiens
4 RPS3A 6189
Affinity Capture-MS Homo sapiens
5 HCST  
Affinity Capture-MS Homo sapiens
6 DNAJC13 23317
Affinity Capture-MS Homo sapiens
7 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SURF4 6836
Affinity Capture-MS Homo sapiens
9 BYSL 705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TYROBP  
Affinity Capture-MS Homo sapiens
11 PNMAL1  
Affinity Capture-MS Homo sapiens
12 ENDOV  
Affinity Capture-MS Homo sapiens
13 SLC30A4 7782
Affinity Capture-MS Homo sapiens
14 AMIGO1  
Affinity Capture-MS Homo sapiens
15 EIF4ENIF1 56478
Two-hybrid Homo sapiens
16 UXS1 80146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 C11orf87  
Affinity Capture-MS Homo sapiens
18 UBE2O 63893
Affinity Capture-MS Homo sapiens
19 IMPDH2 3615
Co-fractionation Homo sapiens
20 RPS8 6202
Affinity Capture-MS Homo sapiens
21 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ITFG3 83986
Affinity Capture-MS Homo sapiens
23 CDCA8 55143
Affinity Capture-MS Homo sapiens
24 MECP2 4204
Affinity Capture-MS Homo sapiens
25 OASL 8638
Affinity Capture-MS Homo sapiens
26 RBM8A 9939
Affinity Capture-MS Homo sapiens
27 RBM19 9904
Affinity Capture-MS Homo sapiens
28 LIN28A  
Affinity Capture-MS Homo sapiens
29 IMPDH1 3614
Co-fractionation Homo sapiens
30 BSG 682
Affinity Capture-MS Homo sapiens
31 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 C10orf12  
Affinity Capture-MS Homo sapiens
33 CDYL 9425
Affinity Capture-MS Homo sapiens
34 CX3CL1  
Affinity Capture-MS Homo sapiens
35 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
36 LIN28B  
Affinity Capture-MS Homo sapiens
37 PDGFRB 5159
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ZBTB47  
Affinity Capture-MS Homo sapiens
39 Ppp6c 67857
Affinity Capture-MS Mus musculus
40 CBX5 23468
Affinity Capture-MS Homo sapiens
41 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
42 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
43 HECTD1 25831
Affinity Capture-MS Homo sapiens
44 DGCR2 9993
Affinity Capture-MS Homo sapiens
45 MAGEB2 4113
Affinity Capture-MS Homo sapiens
46 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
47 IGBP1 3476
Affinity Capture-MS Homo sapiens
48 RSL1D1 26156
Affinity Capture-MS Homo sapiens
49 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CYB5B 80777
Affinity Capture-MS Homo sapiens
51 CXCR4 7852
Affinity Capture-MS Homo sapiens
52 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 BTNL9  
Affinity Capture-MS Homo sapiens
54 RC3H2  
Affinity Capture-MS Homo sapiens
55 RBM47 54502
Affinity Capture-MS Homo sapiens
56 CHST8 64377
Affinity Capture-MS Homo sapiens
57 RPS6 6194
Affinity Capture-MS Homo sapiens
58 CTTN 2017
Affinity Capture-MS Homo sapiens
59 LRRC4C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 FOXL1  
Affinity Capture-MS Homo sapiens
61 PDCD11 22984
Affinity Capture-MS Homo sapiens
62 LPAR1 1902
Affinity Capture-MS Homo sapiens
63 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
64 MRPL15 29088
Affinity Capture-MS Homo sapiens
65 PRR3  
Affinity Capture-MS Homo sapiens
66 C3orf18  
Affinity Capture-MS Homo sapiens
67 RPS13 6207
Affinity Capture-MS Homo sapiens
68 KLRG2 346689
Affinity Capture-MS Homo sapiens
69 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
70 RPS14 6208
Affinity Capture-MS Homo sapiens
71 SCN2B  
Affinity Capture-MS Homo sapiens
72 DDRGK1 65992
Affinity Capture-MS Homo sapiens
73 B3GAT3 26229
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 CCDC8  
Affinity Capture-MS Homo sapiens
75 RPS16 6217
Affinity Capture-MS Homo sapiens
76 AVPR2  
Affinity Capture-MS Homo sapiens
77 GYPA  
Affinity Capture-MS Homo sapiens
78 Gbf1  
Affinity Capture-MS Mus musculus
79 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
80 FBXW11  
Affinity Capture-MS Homo sapiens
81 ADORA2B  
Affinity Capture-MS Homo sapiens
82 TMEM9 252839
Affinity Capture-MS Homo sapiens
83 Ercc6l  
Affinity Capture-MS Mus musculus
84 FBXL6  
Affinity Capture-MS Homo sapiens
85 NLE1 54475
Affinity Capture-MS Homo sapiens
86 LDLRAD1  
Affinity Capture-MS Homo sapiens
87 POLR1C 9533
Co-fractionation Homo sapiens
88 ORC3  
Affinity Capture-MS Homo sapiens
89 CHST5  
Affinity Capture-MS Homo sapiens
90 Pcgf1  
Affinity Capture-MS Mus musculus
91 EFNB1 1947
Affinity Capture-MS Homo sapiens
92 TNFSF12 8742
Affinity Capture-MS Homo sapiens
93 FAM83H 286077
Affinity Capture-MS Homo sapiens
94 DDX58 23586
Affinity Capture-RNA Homo sapiens
95 PTGER3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 NIFK 84365
Affinity Capture-MS Homo sapiens
97 CEP44  
Affinity Capture-MS Homo sapiens
98 E2F4  
Affinity Capture-MS Homo sapiens
99 NCL 4691
Affinity Capture-MS Homo sapiens
100 EXT2 2132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 SEC62 7095
Affinity Capture-MS Homo sapiens
102 GLI4  
Affinity Capture-MS Homo sapiens
103 TCF20  
Affinity Capture-MS Homo sapiens
104 CIT 11113
Affinity Capture-MS Homo sapiens
105 IGF2R 3482
Affinity Capture-MS Homo sapiens
106 BCCIP 56647
Affinity Capture-MS Homo sapiens
107 RPL23A 6147
Affinity Capture-MS Homo sapiens
108 POLR1D 51082
Co-fractionation Homo sapiens
109 ARNTL2  
Affinity Capture-MS Homo sapiens
110 RC3H1 149041
Affinity Capture-MS Homo sapiens
111 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 PRSS23 11098
Affinity Capture-MS Homo sapiens
113 Smn1 20595
Affinity Capture-MS Mus musculus
114 EP300 2033
Affinity Capture-MS Homo sapiens
115 S1PR4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NOP9 is involved
No pathways found





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