Gene description for SLC30A4
Gene name solute carrier family 30 (zinc transporter), member 4
Gene symbol SLC30A4
Other names/aliases ZNT4
Species Homo sapiens
 Database cross references - SLC30A4
ExoCarta ExoCarta_7782
Vesiclepedia VP_7782
Entrez Gene 7782
HGNC 11015
MIM 602095
UniProt O14863  
 SLC30A4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC30A4
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    protein binding GO:0005515 IPI
    antiporter activity GO:0015297 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    response to toxic substance GO:0009636 IDA
    response to zinc ion GO:0010043 IBA
    zinc ion transmembrane transport GO:0071577 IBA
    zinc ion transmembrane transport GO:0071577 IDA
    zinc export across plasma membrane GO:0140882 IEA
    zinc ion import into lysosome GO:0140916 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    lysosomal membrane GO:0005765 IEA
    late endosome GO:0005770 IDA
    plasma membrane GO:0005886 IBA
    endosome membrane GO:0010008 ISS
    late endosome membrane GO:0031902 IEA
 Experiment description of studies that identified SLC30A4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC30A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM60  
Two-hybrid Homo sapiens
2 ANKFY1 51479
Proximity Label-MS Homo sapiens
3 COLEC12 81035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 LAMTOR1 55004
Proximity Label-MS Homo sapiens
5 LEPROTL1 23484
Two-hybrid Homo sapiens
6 PDS5B 23047
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 RAB5A 5868
Proximity Label-MS Homo sapiens
9 RBM25 58517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CIAO1 9391
Affinity Capture-MS Homo sapiens
11 NOP9 161424
Affinity Capture-MS Homo sapiens
12 RAB4A 5867
Proximity Label-MS Homo sapiens
13 GNB4 59345
Affinity Capture-MS Homo sapiens
14 RAB9A 9367
Proximity Label-MS Homo sapiens
15 LAMP1 3916
Proximity Label-MS Homo sapiens
16 IER3IP1 51124
Two-hybrid Homo sapiens
17 TNF  
Two-hybrid Homo sapiens
18 NCAM1 4684
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 METTL9 51108
Affinity Capture-MS Homo sapiens
20 NAPA 8775
Affinity Capture-MS Homo sapiens
21 FUT8 2530
Affinity Capture-MS Homo sapiens
22 LAMP2 3920
Proximity Label-MS Homo sapiens
23 NSG1  
Two-hybrid Homo sapiens
24 BTN2A2  
Two-hybrid Homo sapiens
25 KIAA1524 57650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PRPF40A 55660
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CSTF2 1478
Affinity Capture-MS Homo sapiens
28 GOSR2 9570
Affinity Capture-MS Homo sapiens
29 TMEM189-UBE2V1 387522
Two-hybrid Homo sapiens
30 TMEM100 55273
Two-hybrid Homo sapiens
31 BLK 640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SERP2  
Two-hybrid Homo sapiens
33 B3GAT1  
Proximity Label-MS Homo sapiens
34 HBD 3045
Affinity Capture-MS Homo sapiens
35 PDS5A 23244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 FZD7 8324
Two-hybrid Homo sapiens
37 CMTM5  
Two-hybrid Homo sapiens
38 GNAO1 2775
Affinity Capture-MS Homo sapiens
39 RAB11A 8766
Proximity Label-MS Homo sapiens
40 C19orf25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SPAG9 9043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 YES1 7525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 STX8 9482
Affinity Capture-MS Homo sapiens
44 TNFRSF10C  
Two-hybrid Homo sapiens
45 KRAS 3845
Proximity Label-MS Homo sapiens
46 MLST8 64223
Affinity Capture-MS Homo sapiens
47 YIPF6 286451
Two-hybrid Homo sapiens
48 CLN6  
Two-hybrid Homo sapiens
49 EIF5 1983
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 RAP2A 5911
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC30A4 is involved
No pathways found





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