Gene description for TMEM100
Gene name transmembrane protein 100
Gene symbol TMEM100
Other names/aliases -
Species Homo sapiens
 Database cross references - TMEM100
ExoCarta ExoCarta_55273
Entrez Gene 55273
HGNC 25607
MIM 616334
UniProt Q9NV29  
 TMEM100 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TMEM100
Molecular Function
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
Biological Process
    Notch signaling pathway GO:0007219 IEA
    angiogenesis GO:0001525 IEA
    BMP signaling pathway GO:0030509 IDA
    positive regulation of vasculogenesis GO:2001214 ISS
    regulation of sensory perception of pain GO:0051930 ISS
    positive regulation of endothelial cell differentiation GO:0045603 ISS
    vasculogenesis GO:0001570 IEA
    cellular response to BMP stimulus GO:0071773 IDA
    in utero embryonic development GO:0001701 IEA
    protein kinase B signaling GO:0043491 IEA
    arterial endothelial cell differentiation GO:0060842 IEA
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IDA
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 IDA
    perikaryon GO:0043204 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified TMEM100 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TMEM100
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TMEM100 is involved
No pathways found





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