Gene description for RMDN3
Gene name regulator of microtubule dynamics 3
Gene symbol RMDN3
Other names/aliases FAM82A2
FAM82C
RMD-3
RMD3
ptpip51
Species Homo sapiens
 Database cross references - RMDN3
ExoCarta ExoCarta_55177
Vesiclepedia VP_55177
Entrez Gene 55177
HGNC 25550
MIM 611873
UniProt Q96TC7  
 RMDN3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RMDN3
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 IDA
Biological Process
    intracellular calcium ion homeostasis GO:0006874 IMP
    apoptotic process GO:0006915 IEA
    cell differentiation GO:0030154 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IDA
    spindle microtubule GO:0005876 IBA
    spindle microtubule GO:0005876 IDA
    organelle membrane contact site GO:0044232 IDA
    intercellular bridge GO:0045171 IDA
    mitotic spindle pole GO:0097431 IBA
    mitotic spindle pole GO:0097431 IDA
    presynapse GO:0098793 IEA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified RMDN3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RMDN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 C2CD2L 9854
Proximity Label-MS Homo sapiens
3 SPATS2  
Proximity Label-MS Homo sapiens
4 GPM6A 2823
Affinity Capture-MS Homo sapiens
5 SLC30A8  
Two-hybrid Homo sapiens
6 EMC2 9694
Proximity Label-MS Homo sapiens
7 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
8 ANKLE2 23141
Proximity Label-MS Homo sapiens
9 GEN1  
Proximity Label-MS Homo sapiens
10 FOXA3  
Affinity Capture-MS Homo sapiens
11 MTCH1 23787
Proximity Label-MS Homo sapiens
12 ZCCHC6 79670
Proximity Label-MS Homo sapiens
13 Mtx2  
Affinity Capture-MS Mus musculus
14 FAM111B 374393
Proximity Label-MS Homo sapiens
15 VAPA 9218
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
16 SLC39A4 55630
Affinity Capture-MS Homo sapiens
17 SRPRB 58477
Proximity Label-MS Homo sapiens
18 TANC1 85461
Proximity Label-MS Homo sapiens
19 JPH1 56704
Proximity Label-MS Homo sapiens
20 TMEM147 10430
Two-hybrid Homo sapiens
21 CISD1 55847
Proximity Label-MS Homo sapiens
22 SRPR 6734
Proximity Label-MS Homo sapiens
23 TMEM203  
Two-hybrid Homo sapiens
24 CYB561D2 11068
Two-hybrid Homo sapiens
25 SEC63 11231
Proximity Label-MS Homo sapiens
26 NSDHL 50814
Proximity Label-MS Homo sapiens
27 EGLN1 54583
Proximity Label-MS Homo sapiens
28 RIC8A 60626
Affinity Capture-MS Homo sapiens
29 SLC7A14  
Affinity Capture-MS Homo sapiens
30 PTPN1 5770
Proximity Label-MS Homo sapiens
Co-localization Homo sapiens
Proximity Label-MS Homo sapiens
31 PEBP1 5037
Proximity Label-MS Homo sapiens
32 FFAR1  
Affinity Capture-MS Homo sapiens
33 PEX1 5189
Proximity Label-MS Homo sapiens
34 KIAA1429 25962
Affinity Capture-MS Homo sapiens
35 EMC1 23065
Proximity Label-MS Homo sapiens
36 VANGL2  
Proximity Label-MS Homo sapiens
37 TBL2 26608
Proximity Label-MS Homo sapiens
38 TIMM17B  
Co-fractionation Homo sapiens
39 FIS1 51024
Proximity Label-MS Homo sapiens
40 SECISBP2  
Proximity Label-MS Homo sapiens
41 STRN 6801
Proximity Label-MS Homo sapiens
42 CCDC138  
Proximity Label-MS Homo sapiens
43 PFKFB2 5208
Affinity Capture-MS Homo sapiens
44 DDX24 57062
Proximity Label-MS Homo sapiens
45 FNDC3A 22862
Proximity Label-MS Homo sapiens
46 SPRTN  
Affinity Capture-MS Homo sapiens
47 SMPD4 55627
Proximity Label-MS Homo sapiens
48 NAGA 4668
Affinity Capture-MS Homo sapiens
49 ARMCX4  
Proximity Label-MS Homo sapiens
50 EGFL8  
Two-hybrid Homo sapiens
51 TRDN 10345
Affinity Capture-MS Homo sapiens
52 CIB3  
Affinity Capture-MS Homo sapiens
53 VKORC1 79001
Two-hybrid Homo sapiens
54 MDC1  
Affinity Capture-MS Homo sapiens
55 TOR1A 1861
Affinity Capture-MS Homo sapiens
56 ABCD3 5825
Proximity Label-MS Homo sapiens
57 DDRGK1 65992
Proximity Label-MS Homo sapiens
58 YWHAG 7532
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
59 MARCH5  
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
60 PRKAR2A 5576
Proximity Label-MS Homo sapiens
61 PIGH  
Affinity Capture-MS Homo sapiens
62 ATP2A3 489
Affinity Capture-MS Homo sapiens
63 PGRMC2 10424
Proximity Label-MS Homo sapiens
64 C3orf52  
Affinity Capture-MS Homo sapiens
65 EXD2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
66 TMEM140  
Two-hybrid Homo sapiens
67 SLC25A46 91137
Proximity Label-MS Homo sapiens
68 KIF2C 11004
Proximity Label-MS Homo sapiens
69 YWHAH 7533
Proximity Label-MS Homo sapiens
70 CCDC115 84317
Proximity Label-MS Homo sapiens
71 TOMM40 10452
Co-fractionation Homo sapiens
72 STRIP1 85369
Proximity Label-MS Homo sapiens
73 TOR3A 64222
Affinity Capture-MS Homo sapiens
74 MAVS 57506
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
75 CSNK1D 1453
Proximity Label-MS Homo sapiens
76 FAF2 23197
Proximity Label-MS Homo sapiens
77 HK1 3098
Proximity Label-MS Homo sapiens
78 PGBD5  
Proximity Label-MS Homo sapiens
79 ATP6AP1 537
Proximity Label-MS Homo sapiens
80 ARMCX3 51566
Proximity Label-MS Homo sapiens
81 KIF14 9928
Affinity Capture-MS Homo sapiens
82 PRNP 5621
Affinity Capture-MS Homo sapiens
83 GPN3  
Affinity Capture-MS Homo sapiens
84 CAMLG 819
Proximity Label-MS Homo sapiens
85 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Proximity Label-MS Homo sapiens
86 INSIG2  
Affinity Capture-MS Homo sapiens
87 NUP155 9631
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
88 MAPK1 5594
Co-localization Homo sapiens
89 VPS13D 55187
Proximity Label-MS Homo sapiens
90 UPF3B 65109
Proximity Label-MS Homo sapiens
91 PDIA4 9601
Proximity Label-MS Homo sapiens
92 AUP1 550
Proximity Label-MS Homo sapiens
93 KCNK1  
Affinity Capture-MS Homo sapiens
94 EIF2AK3  
Proximity Label-MS Homo sapiens
95 VEZT 55591
Proximity Label-MS Homo sapiens
96 MTCH2 23788
Proximity Label-MS Homo sapiens
97 SCFD1 23256
Proximity Label-MS Homo sapiens
98 TEX264 51368
Proximity Label-MS Homo sapiens
99 MIS18A  
Proximity Label-MS Homo sapiens
100 EMD 2010
Proximity Label-MS Homo sapiens
101 MOB4 25843
Proximity Label-MS Homo sapiens
102 LUZP1 7798
Proximity Label-MS Homo sapiens
103 PARK2  
Affinity Capture-MS Homo sapiens
104 EMP3 2014
Two-hybrid Homo sapiens
105 CHCHD3 54927
Proximity Label-MS Homo sapiens
106 HSP90B1 7184
Proximity Label-MS Homo sapiens
107 TMEM100 55273
Two-hybrid Homo sapiens
108 ATPAF1  
Proximity Label-MS Homo sapiens
109 SNAP47 116841
Proximity Label-MS Homo sapiens
110 FAM162A 26355
Co-fractionation Homo sapiens
111 SMG6  
Proximity Label-MS Homo sapiens
112 LARP4 113251
Proximity Label-MS Homo sapiens
113 MIOX  
Affinity Capture-MS Homo sapiens
114 CCNB1 891
Proximity Label-MS Homo sapiens
115 CDKAL1  
Proximity Label-MS Homo sapiens
116 PBXIP1 57326
Affinity Capture-MS Homo sapiens
117 YWHAE 7531
Proximity Label-MS Homo sapiens
118 CYSRT1 375791
Co-fractionation Homo sapiens
119 S1PR1 1901
Affinity Capture-MS Homo sapiens
120 TMEM243  
Two-hybrid Homo sapiens
121 GORASP2 26003
Co-fractionation Homo sapiens
122 MIA3 375056
Proximity Label-MS Homo sapiens
123 GK  
Proximity Label-MS Homo sapiens
124 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
125 LMF2 91289
Proximity Label-MS Homo sapiens
126 PREB 10113
Proximity Label-MS Homo sapiens
127 CSNK1E 1454
Proximity Label-MS Homo sapiens
128 VMA21  
Proximity Label-MS Homo sapiens
129 MARCH2  
Proximity Label-MS Homo sapiens
130 STX5 6811
Proximity Label-MS Homo sapiens
131 SP110  
Affinity Capture-MS Homo sapiens
132 STBD1 8987
Proximity Label-MS Homo sapiens
133 PIK3C2A 5286
Proximity Label-MS Homo sapiens
134 AQP12B  
Affinity Capture-MS Homo sapiens
135 C11orf49  
Proximity Label-MS Homo sapiens
136 TMEM131  
Proximity Label-MS Homo sapiens
137 FGFR1OP2  
Proximity Label-MS Homo sapiens
138 RHOT2 89941
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
139 CCDC47 57003
Proximity Label-MS Homo sapiens
140 MFF 56947
Proximity Label-MS Homo sapiens
141 ARMCX2 9823
Proximity Label-MS Homo sapiens
142 SEC61B 10952
Proximity Label-MS Homo sapiens
143 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
144 NFX1  
Proximity Label-MS Homo sapiens
145 SLC7A1 6541
Affinity Capture-MS Homo sapiens
146 ACBD3 64746
Proximity Label-MS Homo sapiens
147 CCDC25 55246
Proximity Label-MS Homo sapiens
148 Rmdn3  
Affinity Capture-MS Mus musculus
149 ANLN 54443
Affinity Capture-MS Homo sapiens
150 HNRNPDL 9987
Co-fractionation Homo sapiens
151 CDS2 8760
Affinity Capture-MS Homo sapiens
152 HNRNPD 3184
Co-fractionation Homo sapiens
153 Rab5c 19345
Affinity Capture-MS Mus musculus
154 HSPA5 3309
Co-fractionation Homo sapiens
155 ZBTB2 57621
Affinity Capture-MS Homo sapiens
156 SMCR8 140775
Proximity Label-MS Homo sapiens
157 VPS13A 23230
Proximity Label-MS Homo sapiens
158 PSEN1 5663
Two-hybrid Homo sapiens
159 EMC3 55831
Proximity Label-MS Homo sapiens
160 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
161 STRN3 29966
Proximity Label-MS Homo sapiens
162 EMC8 10328
Proximity Label-MS Homo sapiens
163 LRRC59 55379
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
164 CDCA3 83461
Proximity Label-MS Homo sapiens
165 PELI2 57161
Two-hybrid Homo sapiens
166 ZNF598 90850
Proximity Label-MS Homo sapiens
167 OCRL 4952
Proximity Label-MS Homo sapiens
168 KCNK18  
Affinity Capture-MS Homo sapiens
169 CAMK1D 57118
Affinity Capture-MS Homo sapiens
170 TMEM209 84928
Proximity Label-MS Homo sapiens
171 Bmpr1a  
Affinity Capture-MS Mus musculus
172 B3GNT3 10331
Affinity Capture-MS Homo sapiens
173 CRELD1 78987
Affinity Capture-MS Homo sapiens
174 BCAP31 10134
Proximity Label-MS Homo sapiens
175 PDIA3 2923
Proximity Label-MS Homo sapiens
176 ATP6AP2 10159
Proximity Label-MS Homo sapiens
177 YWHAZ 7534
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
178 STIM1 6786
Proximity Label-MS Homo sapiens
179 CKAP2  
Proximity Label-MS Homo sapiens
180 INF2 64423
Proximity Label-MS Homo sapiens
181 FKBP8 23770
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
182 MYO19  
Proximity Label-MS Homo sapiens
183 NRM 11270
Two-hybrid Homo sapiens
184 RPGRIP1L 23322
Proximity Label-MS Homo sapiens
185 FOXL1  
Affinity Capture-MS Homo sapiens
186 MTFR1  
Proximity Label-MS Homo sapiens
187 DVL1 1855
Proximity Label-MS Homo sapiens
188 EHBP1 23301
Proximity Label-MS Homo sapiens
189 RPN1 6184
Proximity Label-MS Homo sapiens
190 OCIAD1 54940
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
191 SCYL2 55681
Proximity Label-MS Homo sapiens
192 GRAMD1A  
Proximity Label-MS Homo sapiens
193 HYOU1 10525
Proximity Label-MS Homo sapiens
194 PRKACA 5566
Proximity Label-MS Homo sapiens
195 CCDC77  
Proximity Label-MS Homo sapiens
196 ACSL3 2181
Proximity Label-MS Homo sapiens
197 WDR60 55112
Proximity Label-MS Homo sapiens
198 APOOL 139322
Affinity Capture-MS Homo sapiens
199 FDPS 2224
Affinity Capture-MS Homo sapiens
200 ATP6V1A 523
Co-fractionation Homo sapiens
201 TTC17 55761
Proximity Label-MS Homo sapiens
202 STT3B 201595
Proximity Label-MS Homo sapiens
203 SLC13A3 64849
Two-hybrid Homo sapiens
204 VRK2 7444
Proximity Label-MS Homo sapiens
205 SIRT2 22933
Proximity Label-MS Homo sapiens
206 RAF1 5894
Co-localization Homo sapiens
207 OTULIN 90268
Affinity Capture-MS Homo sapiens
208 GIMAP1  
Two-hybrid Homo sapiens
209 RMDN2 151393
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
211 GANAB 23193
Proximity Label-MS Homo sapiens
212 MTFR2  
Proximity Label-MS Homo sapiens
213 ESYT2 57488
Proximity Label-MS Homo sapiens
214 LEMD3  
Proximity Label-MS Homo sapiens
215 NEUROG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
216 HINT1 3094
Proximity Label-MS Homo sapiens
217 UPF2 26019
Proximity Label-MS Homo sapiens
218 AKAP1 8165
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
219 KCNK16  
Affinity Capture-MS Homo sapiens
220 UBXN4 23190
Proximity Label-MS Homo sapiens
221 ACBD5 91452
Proximity Label-MS Homo sapiens
222 STX2 2054
Two-hybrid Homo sapiens
223 ATP6V1H 51606
Co-fractionation Homo sapiens
224 IMMT 10989
Proximity Label-MS Homo sapiens
225 TTC13  
Proximity Label-MS Homo sapiens
226 LBR 3930
Proximity Label-MS Homo sapiens
227 UCK2 7371
Affinity Capture-MS Homo sapiens
228 KIF2A 3796
Proximity Label-MS Homo sapiens
229 ARRB2 409
Proximity Label-MS Homo sapiens
230 PRKCSH 5589
Proximity Label-MS Homo sapiens
231 ALDH3A2 224
Proximity Label-MS Homo sapiens
232