Gene description for PELI2
Gene name pellino E3 ubiquitin protein ligase family member 2
Gene symbol PELI2
Other names/aliases -
Species Homo sapiens
 Database cross references - PELI2
ExoCarta ExoCarta_57161
Vesiclepedia VP_57161
Entrez Gene 57161
HGNC 8828
MIM 614798
UniProt Q9HAT8  
 PELI2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PELI2
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-ubiquitin ligase activity GO:0034450 TAS
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    protein polyubiquitination GO:0000209 IBA
    positive regulation of protein phosphorylation GO:0001934 IDA
    regulation of Toll signaling pathway GO:0008592 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 TAS
    positive regulation of MAPK cascade GO:0043410 IDA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PELI2 in exosomes
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PELI2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAF7  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 LAMC3  
Two-hybrid Homo sapiens
3 UQCRFS1 7386
Affinity Capture-Western Homo sapiens
4 IRAK2  
Affinity Capture-Western Homo sapiens
5 RNF220  
Two-hybrid Homo sapiens
6 UBQLN4 56893
Two-hybrid Homo sapiens
7 DVL2 1856
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 RBBP8  
Two-hybrid Homo sapiens
9 PCGF2 7703
Two-hybrid Homo sapiens
10 DEAF1 10522
Two-hybrid Homo sapiens
11 FRYL 285527
Two-hybrid Homo sapiens
12 REL 5966
Two-hybrid Homo sapiens
13 NUP62 23636
Two-hybrid Homo sapiens
14 IRAK4 51135
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
15 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 MDFI  
Two-hybrid Homo sapiens
17 ERO1L 30001
Two-hybrid Homo sapiens
18 ROBO1 6091
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 LTBP3 4054
Two-hybrid Homo sapiens
20 IRAK1  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 TGM2 7052
Two-hybrid Homo sapiens
22 PRR36 80164
Two-hybrid Homo sapiens
23 CCNF  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 LZTFL1 54585
Two-hybrid Homo sapiens
25 MAP3K7  
Affinity Capture-Western Homo sapiens
26 HNRNPK 3190
Two-hybrid Homo sapiens
27 FN1 2335
Two-hybrid Homo sapiens
28 THAP7  
Two-hybrid Homo sapiens
29 SP4  
Two-hybrid Homo sapiens
30 TMEM79  
Two-hybrid Homo sapiens
31 CEP170B  
Two-hybrid Homo sapiens
32 MYO10 4651
Two-hybrid Homo sapiens
33 CREB3L3  
Two-hybrid Homo sapiens
34 NR2C2  
Affinity Capture-Western Homo sapiens
35 TRIM32 22954
Two-hybrid Homo sapiens
36 NEK9 91754
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 CLEC17A  
Two-hybrid Homo sapiens
38 IRS1 3667
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
39 PICALM 8301
Two-hybrid Homo sapiens
40 OR7D2  
Two-hybrid Homo sapiens
41 MPDZ  
Two-hybrid Homo sapiens
42 SRPK1 6732
Biochemical Activity Homo sapiens
43 RMDN3 55177
Two-hybrid Homo sapiens
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