Gene description for IRAK4
Gene name interleukin-1 receptor-associated kinase 4
Gene symbol IRAK4
Other names/aliases IPD1
IRAK-4
NY-REN-64
REN64
Species Homo sapiens
 Database cross references - IRAK4
ExoCarta ExoCarta_51135
Vesiclepedia VP_51135
Entrez Gene 51135
HGNC 17967
MIM 606883
UniProt Q9NWZ3  
 IRAK4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for IRAK4
Molecular Function
    protein kinase activity GO:0004672 EXP
    magnesium ion binding GO:0000287 IEA
    protein binding GO:0005515 IPI
    protein serine/threonine kinase activity GO:0004674 TAS
    interleukin-1 receptor binding GO:0005149 IEA
    ATP binding GO:0005524 IEA
Biological Process
    toll-like receptor 4 signaling pathway GO:0034142 TAS
    toll-like receptor 10 signaling pathway GO:0034166 TAS
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IMP
    toll-like receptor 5 signaling pathway GO:0034146 TAS
    cytokine production GO:0001816 IEA
    neutrophil mediated immunity GO:0002446 IMP
    innate immune response GO:0045087 TAS
    toll-like receptor 9 signaling pathway GO:0034162 TAS
    toll-like receptor 2 signaling pathway GO:0034134 TAS
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS
    toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    intracellular signal transduction GO:0035556 IBA
    toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS
    cytokine-mediated signaling pathway GO:0019221 IBA
    toll-like receptor signaling pathway GO:0002224 TAS
    JNK cascade GO:0007254 IEA
    neutrophil migration GO:1990266 IMP
Subcellular Localization
    endosome membrane GO:0010008 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    extracellular space GO:0005615 IEA
    plasma membrane GO:0005886 TAS
    nucleus GO:0005634 IBA
 Experiment description of studies that identified IRAK4 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IRAK4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IRAK1  
Invivo Homo sapiens
Invitro Homo sapiens
2 MYD88 4615
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
3 TRAF6 7189
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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