Gene description for PELI1
Gene name pellino E3 ubiquitin protein ligase 1
Gene symbol PELI1
Other names/aliases -
Species Homo sapiens
 Database cross references - PELI1
ExoCarta ExoCarta_57162
Entrez Gene 57162
HGNC 8827
MIM 614797
UniProt Q96FA3  
 PELI1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PELI1
Molecular Function
    ligase activity GO:0016874 IEA
    ubiquitin-protein transferase activity GO:0004842 IEA
    protein binding GO:0005515 IPI
Biological Process
    response to lipopolysaccharide GO:0032496 IEA
    negative regulation of T cell proliferation GO:0042130 IEA
    toll-like receptor signaling pathway GO:0002224 TAS
    positive regulation of B cell proliferation GO:0030890 IEA
    innate immune response GO:0045087 TAS
    positive regulation of protein ubiquitination GO:0031398 IEA
    positive regulation of toll-like receptor 3 signaling pathway GO:0034141 IEA
    toll-like receptor 9 signaling pathway GO:0034162 TAS
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IEA
    toll-like receptor 5 signaling pathway GO:0034146 TAS
    toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS
    Toll signaling pathway GO:0008063 IEA
    protein K48-linked ubiquitination GO:0070936 IEA
    response to dsRNA GO:0043331 IEA
    positive regulation of cytokine production GO:0001819 IEA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 TAS
    toll-like receptor 4 signaling pathway GO:0034142 TAS
    positive regulation of toll-like receptor 4 signaling pathway GO:0034145 IEA
    toll-like receptor 2 signaling pathway GO:0034134 TAS
    toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS
    toll-like receptor 10 signaling pathway GO:0034166 TAS
Subcellular Localization
    nucleus GO:0005634 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PELI1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PELI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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