Gene description for AGO2
Gene name	argonaute RISC catalytic component 2
Gene symbol	AGO2
Other names/aliases	EIF2C2 Q10
Species	Homo sapiens
Database cross references - AGO2
ExoCarta	ExoCarta_27161
Entrez Gene	27161
HGNC	3263
MIM	606229
UniProt	Q9UKV8
AGO2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246

Gene ontology annotations for AGO2

Molecular Function     siRNA binding GO:0035197 IDA     core promoter binding GO:0001047 IMP     mRNA binding GO:0003729 IEA     RNA polymerase II core binding GO:0000993 IDA     double-stranded RNA binding GO:0003725 IDA     poly(A) RNA binding GO:0044822 IDA     miRNA binding GO:0035198 IDA     endoribonuclease activity, cleaving siRNA-paired mRNA GO:0070551 IDA     single-stranded RNA binding GO:0003727 IDA     protein binding GO:0005515 IPI     metal ion binding GO:0046872 IEA     pre-miRNA binding GO:0070883 IDA     endoribonuclease activity GO:0004521 IDA     endoribonuclease activity, cleaving miRNA-paired mRNA GO:0090624 IMP     translation initiation factor activity GO:0003743 NAS     RNA 7-methylguanosine cap binding GO:0000340 IDA Biological Process     gene expression GO:0010467 TAS     positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 ISS     Notch signaling pathway GO:0007219 TAS     innate immune response GO:0045087 TAS     translational initiation GO:0006413 NAS     siRNA loading onto RISC involved in RNA interference GO:0035087 IDA     miRNA loading onto RISC involved in gene silencing by miRNA GO:0035280 IDA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     negative regulation of translational initiation GO:0045947 IDA     positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 ISS     mRNA cleavage involved in gene silencing by siRNA GO:0090625 IMP     post-embryonic development GO:0009791 IEA     translation GO:0006412 NAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     phosphatidylinositol-mediated signaling GO:0048015 TAS     mRNA cleavage involved in gene silencing by miRNA GO:0035279 IMP     pre-miRNA processing GO:0031054 IDA     RNA secondary structure unwinding GO:0010501 IMP     transcription, DNA-templated GO:0006351 IEA     negative regulation of translation involved in gene silencing by miRNA GO:0035278 IMP     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     gene silencing by RNA GO:0031047 ISS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     miRNA metabolic process GO:0010586 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     production of miRNAs involved in gene silencing by miRNA GO:0035196 IDA     posttranscriptional gene silencing GO:0016441 TAS     RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 IMP Subcellular Localization     cytoplasm GO:0005737 IDA     RISC complex GO:0016442 IDA     cytosol GO:0005829 TAS     mRNA cap binding complex GO:0005845 IDA     nucleoplasm GO:0005654 TAS     polysome GO:0005844 IDA     RISC-loading complex GO:0070578 IDA     micro-ribonucleoprotein complex GO:0035068 IDA     membrane GO:0016020 IDA     cytoplasmic mRNA processing body GO:0000932 IDA     nucleus GO:0005634 IC     ribonucleoprotein complex GO:0030529 IDA