Gene description for TRPM7
Gene name transient receptor potential cation channel, subfamily M, member 7
Gene symbol TRPM7
Other names/aliases ALSPDC
CHAK
CHAK1
LTRPC7
LTrpC-7
TRP-PLIK
Species Homo sapiens
 Database cross references - TRPM7
ExoCarta ExoCarta_54822
Vesiclepedia VP_54822
Entrez Gene 54822
HGNC 17994
MIM 605692
UniProt Q96QT4  
 TRPM7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TRPM7
Molecular Function
    actin binding GO:0003779 IEA
    protein serine/threonine kinase activity GO:0004674 IDA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    calcium channel activity GO:0005262 IBA
    calcium channel activity GO:0005262 IDA
    calcium channel activity GO:0005262 TAS
    zinc ion transmembrane transporter activity GO:0005385 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    magnesium ion transmembrane transporter activity GO:0015095 IDA
    myosin binding GO:0017022 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    metal ion binding GO:0046872 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    calcium ion transport GO:0006816 IBA
    zinc ion transport GO:0006829 ISS
    magnesium ion homeostasis GO:0010960 IDA
    intracellular magnesium ion homeostasis GO:0010961 ISS
    magnesium ion transport GO:0015693 IDA
    calcium-dependent cell-matrix adhesion GO:0016340 IEA
    actomyosin structure organization GO:0031032 IEA
    protein autophosphorylation GO:0046777 IDA
    protein homotetramerization GO:0051289 IEA
    monoatomic cation homeostasis GO:0055080 IBA
    necroptotic process GO:0070266 IMP
    calcium ion transmembrane transport GO:0070588 IDA
    calcium ion transmembrane transport GO:0070588 TAS
    zinc ion transmembrane transport GO:0071577 IEA
    monoatomic cation transmembrane transport GO:0098655 IBA
    magnesium ion transmembrane transport GO:1903830 IEA
Subcellular Localization
    ruffle GO:0001726 IEA
    nucleus GO:0005634 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cytoplasmic vesicle membrane GO:0030659 IEA
    cytoplasmic vesicle GO:0031410 ISS
 Experiment description of studies that identified TRPM7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRPM7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 Tmed2 56334
Affinity Capture-MS Mus musculus
4 OCLN 100506658
Proximity Label-MS Homo sapiens
5 CD3D 915
Affinity Capture-MS Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 RABEP2 79874
Affinity Capture-MS Homo sapiens
9 GJA1 2697
Proximity Label-MS Homo sapiens
10 PSCA 8000
Affinity Capture-MS Homo sapiens
11 ARL15 54622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GJD3  
Proximity Label-MS Homo sapiens
13 PTP4A1 7803
Affinity Capture-MS Homo sapiens
14 LAMP2 3920
Proximity Label-MS Homo sapiens
15 PTPN1 5770
Proximity Label-MS Homo sapiens
16 B3GAT1  
Proximity Label-MS Homo sapiens
17 Eef1a1 13627
Affinity Capture-MS Mus musculus
18 SSR1 6745
Proximity Label-MS Homo sapiens
19 C1qbp 12261
Affinity Capture-MS Mus musculus
20 PLCG1 5335
Reconstituted Complex Homo sapiens
21 C3orf52  
Affinity Capture-MS Homo sapiens
22 MBP 4155
Biochemical Activity Homo sapiens
23 DNAJC16  
Proximity Label-MS Homo sapiens
24 SLC25A46 91137
Proximity Label-MS Homo sapiens
25 RAB35 11021
Proximity Label-MS Homo sapiens
26 PLCB3 5331
Reconstituted Complex Homo sapiens
27 VAPA 9218
Affinity Capture-MS Homo sapiens
28 PLCB1 23236
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
29 LMAN1 3998
Proximity Label-MS Homo sapiens
30 AGO2 27161
Affinity Capture-RNA Homo sapiens
31 KIAA1715 80856
Proximity Label-MS Homo sapiens
32 PXMP2  
Proximity Label-MS Homo sapiens
33 EMD 2010
Proximity Label-MS Homo sapiens
34 EIF2B5 8893
Affinity Capture-MS Homo sapiens
35 MCAM 4162
Proximity Label-MS Homo sapiens
36 DIRAS3  
Proximity Label-MS Homo sapiens
37 TRPM7 54822
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
38 CCDC107  
Affinity Capture-MS Homo sapiens
39 RPN1 6184
Proximity Label-MS Homo sapiens
40 Bub1  
Affinity Capture-MS Mus musculus
41 RHOT2 89941
Proximity Label-MS Homo sapiens
42 ELOVL5 60481
Proximity Label-MS Homo sapiens
43 SEC61B 10952
Proximity Label-MS Homo sapiens
44 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PNLDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SNAP29 9342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 NKAIN1  
Affinity Capture-MS Homo sapiens
48 SEC63 11231
Proximity Label-MS Homo sapiens
49 TTYH1  
Affinity Capture-MS Homo sapiens
50 RAB7A 7879
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
51 LRRC59 55379
Proximity Label-MS Homo sapiens
52 PANX1 24145
Proximity Label-MS Homo sapiens
53 LAMP1 3916
Proximity Label-MS Homo sapiens
54 BCAP31 10134
Proximity Label-MS Homo sapiens
55 HSD3B7 80270
Proximity Label-MS Homo sapiens
56 PKD2L2 27039
Affinity Capture-MS Homo sapiens
57 EGFR 1956
Negative Genetic Homo sapiens
58 FKBP8 23770
Proximity Label-MS Homo sapiens
59 RPN2 6185
Proximity Label-MS Homo sapiens
60 ARF6 382
Proximity Label-MS Homo sapiens
61 HIST3H3 8290
Biochemical Activity Homo sapiens
62 Cep152  
Affinity Capture-MS Mus musculus
63 ATP2A1 487
Proximity Label-MS Homo sapiens
64 RAB9A 9367
Proximity Label-MS Homo sapiens
65 NDC80 10403
Proximity Label-MS Homo sapiens
66 DHFRL1  
Proximity Label-MS Homo sapiens
67 RHOB 388
Proximity Label-MS Homo sapiens
68 CYP2C9  
Proximity Label-MS Homo sapiens
69 KRT19 3880
Proximity Label-MS Homo sapiens
70 KRT18 3875
Proximity Label-MS Homo sapiens
71 FASN 2194
Positive Genetic Homo sapiens
72 PLCB2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
73 TEX28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 RYK 6259
Affinity Capture-MS Homo sapiens
75 Timeless  
Affinity Capture-MS Mus musculus
76 HDAC1 3065
Affinity Capture-MS Homo sapiens
77 NUP155 9631
Proximity Label-MS Homo sapiens
78 ERGIC1 57222
Proximity Label-MS Homo sapiens
79 ERGIC2 51290
Proximity Label-MS Homo sapiens
80 RAB2A 5862
Proximity Label-MS Homo sapiens
81 SEC62 7095
Proximity Label-MS Homo sapiens
82 CEP135  
Proximity Label-MS Homo sapiens
83 Flot1 14251
Affinity Capture-MS Mus musculus
84 DNAJC1 64215
Proximity Label-MS Homo sapiens
85 KRAS 3845
Negative Genetic Homo sapiens
86 RAB5C 5878
Proximity Label-MS Homo sapiens
87 CKAP4 10970
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TRPM7 is involved
PathwayEvidenceSource
Ion channel transport TAS Reactome
Stimuli-sensing channels TAS Reactome
Transport of small molecules TAS Reactome
TRP channels TAS Reactome





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