Gene description for RABEP2
Gene name rabaptin, RAB GTPase binding effector protein 2
Gene symbol RABEP2
Other names/aliases FRA
Species Homo sapiens
 Database cross references - RABEP2
ExoCarta ExoCarta_79874
Vesiclepedia VP_79874
Entrez Gene 79874
HGNC 24817
MIM 611869
UniProt Q9H5N1  
 RABEP2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RABEP2
Molecular Function
    GTPase activator activity GO:0005096 IEA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
Biological Process
    endocytosis GO:0006897 IEA
    signal transduction GO:0007165 IEA
    protein transport GO:0015031 IEA
    cell projection organization GO:0030030 IEA
    regulation of cilium assembly GO:1902017 IMP
Subcellular Localization
    early endosome GO:0005769 IEA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IDA
    ciliary basal body GO:0036064 IDA
    intracellular membrane-bounded organelle GO:0043231 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified RABEP2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RABEP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HOMER1  
Affinity Capture-MS Homo sapiens
2 Heatr2  
Affinity Capture-MS Mus musculus
3 CLIP1 6249
Affinity Capture-MS Homo sapiens
4 FAM167A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SIKE1  
Affinity Capture-MS Homo sapiens
6 NRSN1  
Affinity Capture-MS Homo sapiens
7 FBXO25  
Biochemical Activity Homo sapiens
8 CD2AP 23607
Co-fractionation Homo sapiens
9 STRN3 29966
Affinity Capture-MS Homo sapiens
10 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
11 HNRNPR 10236
Co-fractionation Homo sapiens
12 SYVN1 84447
Affinity Capture-MS Homo sapiens
13 AGAP3 116988
Affinity Capture-MS Homo sapiens
14 MAP3K5 4217
Affinity Capture-MS Homo sapiens
15 CDC16 8881
Affinity Capture-MS Homo sapiens
16 STRN 6801
Affinity Capture-MS Homo sapiens
17 NOLC1 9221
Co-fractionation Homo sapiens
18 KLC2 64837
Affinity Capture-MS Homo sapiens
19 SPAG9 9043
Co-fractionation Homo sapiens
20 CCDC138  
Affinity Capture-MS Homo sapiens
21 BRCC3 79184
Co-fractionation Homo sapiens
22 RGS9BP  
Affinity Capture-MS Homo sapiens
23 CDC27 996
Affinity Capture-MS Homo sapiens
24 STRIP1 85369
Affinity Capture-MS Homo sapiens
25 CPNE5 57699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 MTA2 9219
Co-fractionation Homo sapiens
27 EXOC3 11336
Affinity Capture-MS Homo sapiens
28 IFT20 90410
Affinity Capture-MS Homo sapiens
29 C15orf59  
Affinity Capture-MS Homo sapiens
30 RABGEF1 27342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SPAG5 10615
Affinity Capture-MS Homo sapiens
32 C1orf122  
Affinity Capture-MS Homo sapiens
33 CPNE2 221184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MOB4 25843
Affinity Capture-MS Homo sapiens
35 KLC1 3831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 CEP192 55125
Affinity Capture-MS Homo sapiens
37 RABEP1 9135
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
38 EXOC4 60412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 RAB4A 5867
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
40 CEP152  
Affinity Capture-MS Homo sapiens
41 KIF5A 3798
Affinity Capture-MS Homo sapiens
42 NTRK1 4914
Affinity Capture-MS Homo sapiens
43 FOXK2  
Affinity Capture-MS Homo sapiens
44 TRPM7 54822
Affinity Capture-MS Homo sapiens
45 PPP1R21 129285
Affinity Capture-MS Homo sapiens
46 GET4 51608
Co-fractionation Homo sapiens
47 CPNE4 131034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 POLR2B 5431
Co-fractionation Homo sapiens
49 FAM189B  
Affinity Capture-MS Homo sapiens
50 RAP1GDS1 5910
Affinity Capture-MS Homo sapiens
51 RAB5A 5868
Reconstituted Complex Homo sapiens
52 POLR2E 5434
Co-fractionation Homo sapiens
53 SDCCAG8  
Affinity Capture-MS Homo sapiens
54 IFT57 55081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 NR3C1 2908
Co-fractionation Homo sapiens
56 SHQ1  
Affinity Capture-MS Homo sapiens
57 MAP3K1 4214
Biochemical Activity Homo sapiens
58 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 UACA 55075
Affinity Capture-MS Homo sapiens
60 SASS6 163786
Affinity Capture-MS Homo sapiens
61 COG6 57511
Affinity Capture-MS Homo sapiens
62 PCBP1 5093
Affinity Capture-MS Homo sapiens
63 DIRAS1 148252
Affinity Capture-MS Homo sapiens
64 FRAT1 10023
Two-hybrid Homo sapiens
65 PTPRB 5787
Proximity Label-MS Homo sapiens
66 SH3GLB2 56904
Affinity Capture-MS Homo sapiens
67 TMEM74  
Affinity Capture-MS Homo sapiens
68 FOXK1 221937
Affinity Capture-MS Homo sapiens
69 HUWE1 10075
Co-fractionation Homo sapiens
70 ZRANB1 54764
Affinity Capture-MS Homo sapiens
71 DENND6A 201627
Affinity Capture-MS Homo sapiens
72 SLMAP 7871
Affinity Capture-MS Homo sapiens
73 MAP1S 55201
Affinity Capture-MS Homo sapiens
74 TRIM45  
Affinity Capture-MS Homo sapiens
75 VPS52 6293
Two-hybrid Homo sapiens
76 HECTD4 283450
Affinity Capture-MS Homo sapiens
77 STRN4 29888
Affinity Capture-MS Homo sapiens
78 HDAC1 3065
Co-fractionation Homo sapiens
79 C19orf25  
Affinity Capture-MS Homo sapiens
80 KLHL7  
Affinity Capture-MS Homo sapiens
81 WWP2 11060
Biochemical Activity Homo sapiens
82 LARP7 51574
Co-fractionation Homo sapiens
83 PSMA5 5686
Affinity Capture-MS Homo sapiens
84 FGFR1OP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 LRRC61 65999
Affinity Capture-MS Homo sapiens
86 GOLM1 51280
Affinity Capture-MS Homo sapiens
87 WDHD1  
Co-fractionation Homo sapiens
88 ASB7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RABEP2 is involved
No pathways found





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