Gene description for HECTD4
Gene name HECT domain containing E3 ubiquitin protein ligase 4
Gene symbol HECTD4
Other names/aliases C12orf51
POTAGE
Species Homo sapiens
 Database cross references - HECTD4
ExoCarta ExoCarta_283450
Entrez Gene 283450
HGNC 26611
 HECTD4 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for HECTD4
Molecular Function
    ligase activity GO:0016874 IEA
    ubiquitin-protein transferase activity GO:0004842 IBA
Biological Process
    glucose metabolic process GO:0006006 IMP
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA
    glucose homeostasis GO:0042593 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified HECTD4 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for HECTD4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HECTD4 is involved
No pathways found





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