Gene description for Pdlim5
Gene name PDZ and LIM domain 5
Gene symbol Pdlim5
Other names/aliases 1110001A05Rik
AI987914
C87059
Enh
Enh1
Enh2
Enh3
LIM
Species Mus musculus
 Database cross references - Pdlim5
ExoCarta ExoCarta_56376
Vesiclepedia VP_56376
Entrez Gene 56376
UniProt Q8CI51  
 Pdlim5 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pdlim5
Molecular Function
    protein N-terminus binding GO:0047485 ISO
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    protein kinase C binding GO:0005080 ISO
    actin binding GO:0003779 ISO
    actinin binding GO:0042805 ISO
    zinc ion binding GO:0008270 IEA
Biological Process
    regulation of dendritic spine morphogenesis GO:0061001 ISO
    regulation of synapse assembly GO:0051963 ISO
Subcellular Localization
    cytosol GO:0005829 ISO
    Z disc GO:0030018 IDA
    postsynaptic density GO:0014069 ISO
    postsynaptic membrane GO:0045211 IEA
    synapse GO:0045202 IEA
    plasma membrane GO:0005886 IEA
    neuron projection GO:0043005 IEA
    actin cytoskeleton GO:0015629 ISO
    cytoplasm GO:0005737 IEA
    cell junction GO:0030054 IEA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Pdlim5 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pdlim5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pdlim5 is involved
No pathways found





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