Gene description for TUBGCP6
Gene name tubulin, gamma complex associated protein 6
Gene symbol TUBGCP6
Other names/aliases GCP-6
GCP6
MCCRP
MCCRP1
MCPHCR
Species Homo sapiens
 Database cross references - TUBGCP6
ExoCarta ExoCarta_85378
Vesiclepedia VP_85378
Entrez Gene 85378
HGNC 18127
MIM 610053
UniProt Q96RT7  
 TUBGCP6 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TUBGCP6
Molecular Function
    microtubule binding GO:0008017 IDA
    gamma-tubulin binding GO:0043015 IBA
    microtubule minus-end binding GO:0051011 IBA
Biological Process
    mitotic cell cycle GO:0000278 IBA
    microtubule nucleation GO:0007020 IBA
    microtubule nucleation GO:0007020 IDA
    cytoplasmic microtubule organization GO:0031122 IBA
    spindle assembly GO:0051225 IBA
    meiotic cell cycle GO:0051321 IBA
Subcellular Localization
    spindle pole GO:0000922 IEA
    gamma-tubulin complex GO:0000930 IBA
    gamma-tubulin ring complex GO:0000931 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 TAS
    microtubule GO:0005874 IEA
    membrane GO:0016020 HDA
 Experiment description of studies that identified TUBGCP6 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TUBGCP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC7 7266
Proximity Label-MS Homo sapiens
2 PRICKLE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ARMC5 79798
Affinity Capture-MS Homo sapiens
4 HES6  
Affinity Capture-MS Homo sapiens
5 BTRC 8945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 Tubgcp5  
Affinity Capture-MS Mus musculus
8 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
9 Mzt1  
Affinity Capture-MS Mus musculus
10 MIF4GD 57409
Affinity Capture-MS Homo sapiens
11 UBA1 7317
Affinity Capture-MS Homo sapiens
12 TUBGCP5 114791
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TP53 7157
Affinity Capture-MS Homo sapiens
14 MZT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 WWP1 11059
Affinity Capture-MS Homo sapiens
16 TUBG1 7283
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
17 TUBG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 C1orf106  
Affinity Capture-MS Homo sapiens
19 Fam83d  
Affinity Capture-MS Mus musculus
20 ZNF385C  
Affinity Capture-MS Homo sapiens
21 KCTD14 65987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TRIM66  
Affinity Capture-MS Homo sapiens
23 MZT2B 80097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 Tubgcp4 51885
Affinity Capture-MS Mus musculus
25 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
26 PRG2  
Affinity Capture-MS Homo sapiens
27 BAG2 9532
Affinity Capture-MS Homo sapiens
28 FBXW5  
Affinity Capture-MS Homo sapiens
29 TXNDC12 51060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 B4GALT2  
Affinity Capture-MS Homo sapiens
31 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
32 DUSP16  
Affinity Capture-MS Homo sapiens
33 RIPK4  
Affinity Capture-MS Homo sapiens
34 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
35 CDC16 8881
Affinity Capture-MS Homo sapiens
36 NXF1 10482
Affinity Capture-RNA Homo sapiens
37 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
38 CD2BP2 10421
Affinity Capture-MS Homo sapiens
39 C12orf74  
Affinity Capture-MS Homo sapiens
40 LRWD1  
Affinity Capture-MS Homo sapiens
41 LOXL4 84171
Affinity Capture-MS Homo sapiens
42 INF2 64423
Affinity Capture-MS Homo sapiens
43 EEF1D 1936
Affinity Capture-MS Homo sapiens
44 NEDD1 121441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 NTRK1 4914
Affinity Capture-MS Homo sapiens
46 Tubg1 103733
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
47 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 BRD1 23774
Affinity Capture-MS Homo sapiens
49 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SCAF11  
Affinity Capture-MS Homo sapiens
51 Mzt2  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
52 Nedd1  
Affinity Capture-MS Mus musculus
53 CCDC96  
Affinity Capture-MS Homo sapiens
54 KIAA1683  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 Tubgcp3  
Affinity Capture-MS Mus musculus
56 Pdlim5 56376
Affinity Capture-MS Mus musculus
57 FOXD4L6  
Affinity Capture-MS Homo sapiens
58 HSPB8 26353
Affinity Capture-MS Homo sapiens
59 UBXN6 80700
Affinity Capture-MS Homo sapiens
60 Lgals3bp 19039
Affinity Capture-MS Mus musculus
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