Gene description for MZT2B
Gene name mitotic spindle organizing protein 2B
Gene symbol MZT2B
Other names/aliases FAM128B
MOZART2B
Species Homo sapiens
 Database cross references - MZT2B
ExoCarta ExoCarta_80097
Vesiclepedia VP_80097
Entrez Gene 80097
HGNC 25886
MIM 613450
UniProt Q6NZ67  
 MZT2B identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MZT2B
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    gamma-tubulin ring complex GO:0000931 IDA
    nucleoplasm GO:0005654 IDA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    spindle GO:0005819 IBA
    spindle GO:0005819 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified MZT2B in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MZT2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 WWP1 11059
Affinity Capture-MS Homo sapiens
3 GPR17 2840
Affinity Capture-MS Homo sapiens
4 CSTL1  
Affinity Capture-MS Homo sapiens
5 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 Tubgcp2  
Affinity Capture-MS Mus musculus
8 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 GPR45  
Affinity Capture-MS Homo sapiens
10 PTH1R  
Affinity Capture-MS Homo sapiens
11 CXCR4 7852
Affinity Capture-MS Homo sapiens
12 UBA1 7317
Affinity Capture-MS Homo sapiens
13 TUBGCP5 114791
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ICAM1 3383
Affinity Capture-MS Homo sapiens
15 TP53 7157
Affinity Capture-MS Homo sapiens
16 MZT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ARHGEF11 9826
Affinity Capture-MS Homo sapiens
18 FPR1  
Affinity Capture-MS Homo sapiens
19 TUBG1 7283
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TUBG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 DUOXA2  
Affinity Capture-MS Homo sapiens
22 MFSD4  
Affinity Capture-MS Homo sapiens
23 DNAJC2 27000
Affinity Capture-MS Homo sapiens
24 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
25 MLC1 23209
Affinity Capture-MS Homo sapiens
26 PTH2R  
Affinity Capture-MS Homo sapiens
27 HSPA14 51182
Affinity Capture-MS Homo sapiens
28 CDC37 11140
Two-hybrid Homo sapiens
29 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 NRSN2  
Affinity Capture-MS Homo sapiens
31 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CUL3 8452
Affinity Capture-MS Homo sapiens
33 NINL  
Proximity Label-MS Homo sapiens
34 EFNA4  
Affinity Capture-MS Homo sapiens
35 NPY2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 HCST  
Affinity Capture-MS Homo sapiens
37 SLC5A6 8884
Affinity Capture-MS Homo sapiens
38 TXNDC12 51060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 IQCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 KDELR2 11014
Affinity Capture-MS Homo sapiens
41 SETDB1  
Two-hybrid Homo sapiens
42 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 OCIAD1 54940
Affinity Capture-MS Homo sapiens
44 Tubgcp6  
Affinity Capture-MS Mus musculus
45 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
46 SLC18A2  
Affinity Capture-MS Homo sapiens
47 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TREM1 54210
Affinity Capture-MS Homo sapiens
49 MYC  
Affinity Capture-MS Homo sapiens
50 NIN 51199
Proximity Label-MS Homo sapiens
51 NEDD1 121441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 P2RY10  
Affinity Capture-MS Homo sapiens
53 NME7 29922
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 Tubg1 103733
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
55 GPR182  
Affinity Capture-MS Homo sapiens
56 SLCO1B1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 HSPA1A 3303
Affinity Capture-MS Homo sapiens
58 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 CCDC114  
Affinity Capture-MS Homo sapiens
60 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 Mzt2  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
62 CMTM8  
Affinity Capture-MS Homo sapiens
63 CEBPA  
Protein-peptide Homo sapiens
64 SEMA4C 54910
Affinity Capture-MS Homo sapiens
65 Tubgcp3  
Affinity Capture-MS Mus musculus
66 TUBGCP6 85378
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 C16orf58 64755
Affinity Capture-MS Homo sapiens
69 BTNL9  
Affinity Capture-MS Homo sapiens
70 DGCR2 9993
Affinity Capture-MS Homo sapiens
71 AVPR2  
Affinity Capture-MS Homo sapiens
72 Lgals3bp 19039
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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