ExoCarta: Gene summary

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Gene description for WWP1
Gene name	WW domain containing E3 ubiquitin protein ligase 1
Gene symbol	WWP1
Other names/aliases	AIP5 Tiul1 hSDRP1
Species	Homo sapiens
Database cross references - WWP1
ExoCarta	ExoCarta_11059
Vesiclepedia	VP_11059
Entrez Gene	11059
HGNC	17004
MIM	602307
UniProt	Q9H0M0
WWP1 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells	34887515
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for WWP1

Molecular Function
	ubiquitin-protein transferase activity	GO:0004842	TAS
	protein binding	GO:0005515	IPI
	ubiquitin protein ligase activity	GO:0061630	IBA
Biological Process
	signal transduction	GO:0007165	NAS
	central nervous system development	GO:0007417	NAS
	protein ubiquitination	GO:0016567	IEA
	protein ubiquitination	GO:0016567	TAS
	monoatomic ion transmembrane transport	GO:0034220	TAS
	proteasome-mediated ubiquitin-dependent protein catabolic process	GO:0043161	IBA
	negative regulation of DNA-templated transcription	GO:0045892	ISS
	symbiont entry into host cell	GO:0046718	TAS
Subcellular Localization
	ubiquitin ligase complex	GO:0000151	NAS
	nucleus	GO:0005634	IEA
	cytoplasm	GO:0005737	IBA
	cytosol	GO:0005829	TAS
	plasma membrane	GO:0005886	IEA
	extracellular exosome	GO:0070062	HDA
	anchoring junction	GO:0070161	IEA

Experiment description of studies that identified WWP1 in sEVs

Experiment ID

1203

MISEV standards
✔ EM	Biophysical techniques
✔ SDCBP\|FLOT1\|CD9\|CD81\|CD63\|EPCAM\|GAPDH\|LAMP1\|TFRC\|CD151\|CD82\|LAMP2\|RAB35\|TSG101\|FLOT2\|RAB5B\|ICAM1\|RAB5A	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

34887515

Organism

Homo sapiens

Experiment description

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Authors

"Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."

Journal name

Nat Cell Biol

Publication year

2021

Sample

Colorectal cancer cells

Sample name

DiFi

Isolation/purification methods

Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation

Flotation density

Molecules identified in the study

Protein
miRNA

Methods used in the study

Western blotting
Mass spectrometry
RNA sequencing

Experiment ID

231

MISEV standards
✘	Biophysical techniques
✔ Alix\|CD63\|CD9	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

25332113

Organism

Homo sapiens

Experiment description

Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets

Authors

"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."

Journal name

Transfusion

Publication year

2015

Sample

Platelets

Sample name

PL-Exs - Rep 1

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient

Flotation density

1.12-1.15 g/mL

Molecules identified in the study

Protein
Lipids

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

232

MISEV standards
✘	Biophysical techniques
✘	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

25332113

Organism

Homo sapiens

Experiment description

Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets

Authors

"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."

Journal name

Transfusion

Publication year

2015

Sample

Platelets

Sample name

PL-Exs - Rep 2

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient

Flotation density

1.12-1.15 g/mL

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Experiment ID

233

MISEV standards
✘	Biophysical techniques
✘	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

25332113

Organism

Homo sapiens

Experiment description

Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets

Authors

"Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."

Journal name

Transfusion

Publication year

2015

Sample

Platelets

Sample name

PL-Exs - Rep 3

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient

Flotation density

1.12-1.15 g/mL

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for WWP1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

HNRNPH1

3187

Affinity Capture-RNA

Homo sapiens

POLR2G

5436

Affinity Capture-MS

Homo sapiens

Mtx1

Affinity Capture-MS

Mus musculus

AXL

558

Affinity Capture-MS

Homo sapiens

FLOT2

2319

Affinity Capture-MS

Homo sapiens

KLF2

10365

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens

RECQL5

Affinity Capture-MS

Homo sapiens

SCNN1A

Two-hybrid

Homo sapiens

TRIML1

Affinity Capture-MS

Homo sapiens

MC1R

4157

Affinity Capture-MS

Homo sapiens

BCLAF1

9774

Affinity Capture-MS

Homo sapiens

WWP1

11059

Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens

RPL30

6156

Affinity Capture-MS

Homo sapiens

NME7

29922

Affinity Capture-MS

Homo sapiens

VPRBP

9730

Affinity Capture-MS

Homo sapiens

TRIM66

Affinity Capture-MS

Homo sapiens

TP63

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens

SMAD4

Affinity Capture-Western

Homo sapiens

RPL10

6134

Affinity Capture-MS

Homo sapiens

USP9X

8239

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

FAM189B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

UBC

7316

Biochemical Activity

Homo sapiens

FAM168A

Affinity Capture-MS

Homo sapiens

DVL3

1857

Affinity Capture-Western

Homo sapiens

ELAVL1

1994

Affinity Capture-MS

Homo sapiens

ATN1

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

RTN4

57142

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

LRP10

26020

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

FAU

2197

Affinity Capture-MS

Homo sapiens

AMOTL1

154810

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

URI1

Affinity Capture-MS

Homo sapiens

RPS11

6205

Affinity Capture-MS

Homo sapiens

RPL10A

4736

Affinity Capture-MS

Homo sapiens

RPL28

6158

Affinity Capture-MS

Homo sapiens

BRCC3

79184

Affinity Capture-MS

Homo sapiens

NONO

4841

Affinity Capture-MS

Homo sapiens

ADAM9

8754

Affinity Capture-MS

Homo sapiens

ZNF638

27332

Two-hybrid

Homo sapiens

POLR2I

5438

Affinity Capture-MS

Homo sapiens

PCBD1

5092

Two-hybrid

Homo sapiens

RPL24

6152

Affinity Capture-MS

Homo sapiens

SEC23IP

11196

Affinity Capture-MS

Homo sapiens

MUC1

4582

Affinity Capture-MS

Homo sapiens

CPSF7

79869

Affinity Capture-MS

Homo sapiens

TNFRSF19

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

EWSR1

2130

Two-hybrid

Homo sapiens

RPS9

6203

Affinity Capture-MS

Homo sapiens

RPLP2

6181

Affinity Capture-MS

Homo sapiens

KTN1

3895

Affinity Capture-MS

Homo sapiens

LACTB

114294

Affinity Capture-MS

Homo sapiens

DGCR2

9993

Affinity Capture-MS

Homo sapiens

TUBGCP6

85378

Affinity Capture-MS

Homo sapiens

PTPN14

5784

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ASH2L

9070

Two-hybrid

Homo sapiens

POLR2C

5432

Affinity Capture-MS

Homo sapiens

SNAP23

8773

Affinity Capture-MS

Homo sapiens

LDLRAD4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SMAD5

4090

Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens

H2AFY2

55506

Two-hybrid

Homo sapiens

POLR2M

Affinity Capture-MS

Homo sapiens

WBP2

23558

Protein-peptide		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

STAT6

6778

Two-hybrid

Homo sapiens

FAM120A

23196

Affinity Capture-MS

Homo sapiens

DVL2

1856

Affinity Capture-Western		Homo sapiens
Co-localization		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

RNF11

26994

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Co-localization		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

MZT1

Affinity Capture-MS

Homo sapiens

GPN3

Affinity Capture-MS

Homo sapiens

TMEM255A

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TRAF4

9618

Two-hybrid

Homo sapiens

Bcas2

Affinity Capture-MS

Mus musculus

EDC4

23644

Affinity Capture-MS

Homo sapiens

AMOTL2

51421

Affinity Capture-MS

Homo sapiens

PHF20L1

Two-hybrid

Homo sapiens

HIST1H1T

3010

Affinity Capture-MS

Homo sapiens

WRNIP1

56897

Affinity Capture-MS

Homo sapiens

NPC1

4864

Affinity Capture-MS

Homo sapiens

ARRDC1

92714

Reconstituted Complex		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

RAB14

51552

Affinity Capture-MS

Homo sapiens

WBP1

Protein-peptide		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TMEM55B

90809

Affinity Capture-MS

Homo sapiens

SRSF3

6428

Affinity Capture-MS

Homo sapiens

TUBGCP4

27229

Affinity Capture-MS

Homo sapiens

CBL

867

Biochemical Activity

Homo sapiens

PDLIM2

Affinity Capture-MS

Homo sapiens

DAZAP2

Two-hybrid

Homo sapiens

LAPTM5

7805

Two-hybrid

Homo sapiens

RPL18A

6142

Affinity Capture-MS

Homo sapiens

PTPN21

11099

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CCDC85C

Affinity Capture-MS

Homo sapiens

ARRDC2

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SARAF

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HIVEP3

59269

Affinity Capture-Western

Homo sapiens

SMAD3

4088

Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens

SMAD2

4087

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

YWHAQ

10971

Reconstituted Complex

Homo sapiens

SRSF1

6426

Affinity Capture-MS

Homo sapiens

BCL2L1

598

Affinity Capture-MS

Homo sapiens

UBE2D3

7323

Reconstituted Complex

Homo sapiens

BRAF

Affinity Capture-Western

Homo sapiens

100

SRSF5

6430

Affinity Capture-MS

Homo sapiens

101

LZTR1

8216

Two-hybrid

Homo sapiens

102

RPS16

6217

Affinity Capture-MS

Homo sapiens

103

ITCH

83737

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

104

POLR2B

5431

Affinity Capture-MS

Homo sapiens

105

MCTP2

Affinity Capture-MS

Homo sapiens

106

POLR2J

Affinity Capture-MS

Homo sapiens

107

PRRG4

Reconstituted Complex

Homo sapiens

108

RBBP6

5930

Affinity Capture-MS

Homo sapiens

109

CASP14

23581

Affinity Capture-MS

Homo sapiens

110

FNDC3B

64778

Affinity Capture-MS

Homo sapiens

111

SLC2A1

6513

Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

112

CBFA2T3

Affinity Capture-MS

Homo sapiens

113

ARRDC4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

114

NDFIP2

54602

Affinity Capture-MS

Homo sapiens

115

PNN

5411

Affinity Capture-MS

Homo sapiens

116

ERBB2IP

55914

Affinity Capture-MS

Homo sapiens

117

UBE2L3

7332

Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens

118

TMEM255B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

119

PRKAA2

5563

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens

120

Smad3

Affinity Capture-MS

Mus musculus

121

MZT2B

80097

Affinity Capture-MS

Homo sapiens

122

TRAF6

7189

Affinity Capture-Western

Homo sapiens

123

PTEN

5728

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

124

ERBB4

2066

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens

125

GPN1

Affinity Capture-MS

Homo sapiens

126

RPL3

6122

Affinity Capture-MS

Homo sapiens

127

EGFR

1956

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

128

SETD4

54093

Affinity Capture-MS

Homo sapiens

129

HNRNPA1

3178

Affinity Capture-MS

Homo sapiens

130

SERINC5

256987

Affinity Capture-MS

Homo sapiens

131

TP73

Affinity Capture-MS

Homo sapiens

132

SMAD1

4086

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

133

PHB2

11331

Affinity Capture-MS

Homo sapiens

134

UBE2D2

7322

Biochemical Activity		Homo sapiens
Reconstituted Complex		Homo sapiens

135

POLR2D

Affinity Capture-MS

Homo sapiens

136

TJP2

9414

Affinity Capture-MS

Homo sapiens

137

LDLRAD3

Affinity Capture-MS

Homo sapiens

138

ARRDC3

57561

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

139

RUNX2

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

140

EEF1A2

1917

Affinity Capture-MS

Homo sapiens

141

EEF1B2

1933

Affinity Capture-MS

Homo sapiens

142

DDB1

1642

Affinity Capture-MS

Homo sapiens

143

AMOT

154796

Affinity Capture-MS

Homo sapiens

144

RRBP1

6238

Affinity Capture-MS

Homo sapiens

145

SMAD6

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

146

PDE1C

5137

Affinity Capture-MS

Homo sapiens

147

LATS1

Protein-peptide

Homo sapiens

148

POLR2A

5430

Affinity Capture-MS

Homo sapiens

149

FLOT1

10211

Affinity Capture-MS

Homo sapiens

150

XRCC5

7520

Affinity Capture-MS

Homo sapiens

151

ICA1

Affinity Capture-MS

Homo sapiens

152

UBE2D1

7321

Reconstituted Complex

Homo sapiens

153

RPL19

6143

Affinity Capture-MS

Homo sapiens

154

RBM14

10432

Affinity Capture-MS

Homo sapiens

155

FBXL15

Affinity Capture-Western

Homo sapiens

156

PDLIM7

9260

Affinity Capture-MS

Homo sapiens

157

TMEM51

55092

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

158

DVL1

1855

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

159

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

160

ESR2

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

161

FAM175B

23172

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

162

DIDO1

Two-hybrid

Homo sapiens

163

SKIL

Affinity Capture-Western

Homo sapiens

164

SMAD7

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

165

CPSF6

11052

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

166

TP53

7157

Reconstituted Complex

Homo sapiens

167

CDK8

1024

Affinity Capture-MS

Homo sapiens

168

U2AF1L4

199746

Affinity Capture-MS

Homo sapiens

169

TUBG2

Affinity Capture-MS

Homo sapiens

170

ERH

2079

Affinity Capture-MS

Homo sapiens

171

PDIA4

9601

Affinity Capture-MS

Homo sapiens

172

EZR

7430

Affinity Capture-Western

Homo sapiens

173

ARF5

381

Affinity Capture-MS

Homo sapiens

174

PRRG1

5638

Affinity Capture-MS

Homo sapiens

175

IKBKG

8517

Two-hybrid

Homo sapiens

176

LITAF

9516

Affinity Capture-Western

Homo sapiens

177

RPAP2

Affinity Capture-MS

Homo sapiens

178

THRAP3

9967

Affinity Capture-MS

Homo sapiens

179

ILDR1

286676

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

180

HSPB1

3315

Two-hybrid

Homo sapiens

181

CLUH

23277

Affinity Capture-MS

Homo sapiens

182

LRP12

29967

Affinity Capture-MS

Homo sapiens

183

CAPNS1

826

Affinity Capture-MS

Homo sapiens

184

HSP90AA1

3320

Affinity Capture-Luminescence

Homo sapiens

185

EIF4A3

9775

Affinity Capture-MS

Homo sapiens

186

SIRT1

Affinity Capture-Western

Homo sapiens

187

ARF4

378

Affinity Capture-MS

Homo sapiens

188

NDFIP1

80762

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

189

SFTPC

Reconstituted Complex

Homo sapiens

190

KLF5

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

191

WWP2

11060

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

192

TXN

7295

Affinity Capture-MS

Homo sapiens

193

EZH2

Affinity Capture-MS

Homo sapiens

194

RPSA

3921

Affinity Capture-MS

Homo sapiens

195

EEF1D

1936

Affinity Capture-MS

Homo sapiens

196

HIST1H4J

8363

Affinity Capture-MS

Homo sapiens

197

RPS7

6201

Affinity Capture-MS

Homo sapiens

198

FBXL18

80028

Two-hybrid

Homo sapiens

199

SPG20

23111

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Co-localization		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

200

FAM189A2

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens

201

TXNIP

10628

Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

202

NUFIP2

57532

Affinity Capture-MS

Homo sapiens

203

CUEDC1

404093

Affinity Capture-MS

Homo sapiens

204

PTCH1

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

205

RAPGEF6

51735

Affinity Capture-MS

Homo sapiens

206

CORO1C

23603

Affinity Capture-MS

Homo sapiens

207

SCAMP3

10067

Affinity Capture-MS

Homo sapiens

208

ZNF846

Affinity Capture-MS

Homo sapiens

209

NOTCH1

4851

Co-localization		Homo sapiens
Reconstituted Complex		Homo sapiens

210

LNX1

Two-hybrid

Homo sapiens

211

SCRT1

83482

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which WWP1 is involved

Pathway	Evidence	Source
Adaptive Immune System	TAS	Reactome
Antigen processing: Ubiquitination & Proteasome degradation	TAS	Reactome
Class I MHC mediated antigen processing & presentation	TAS	Reactome
Downregulation of ERBB4 signaling	TAS	Reactome
Gene expression (Transcription)	IEA	Reactome
Generic Transcription Pathway	IEA	Reactome
Immune System	TAS	Reactome
Ion channel transport	TAS	Reactome
Regulation of RUNX2 expression and activity	IEA	Reactome
RNA Polymerase II Transcription	IEA	Reactome
Signal Transduction	TAS	Reactome
Signaling by ERBB4	TAS	Reactome
Signaling by Receptor Tyrosine Kinases	TAS	Reactome
Stimuli-sensing channels	TAS	Reactome
Transcriptional regulation by RUNX2	IEA	Reactome
Transport of small molecules	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here