Gene description for FBXL18
Gene name F-box and leucine-rich repeat protein 18
Gene symbol FBXL18
Other names/aliases Fbl18
Species Homo sapiens
 Database cross references - FBXL18
ExoCarta ExoCarta_80028
Vesiclepedia VP_80028
Entrez Gene 80028
HGNC 21874
MIM 609084
UniProt Q96ME1  
 FBXL18 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FBXL18
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified FBXL18 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FBXL18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP4-12  
Two-hybrid Homo sapiens
2 NOTCH2NL 388677
Two-hybrid Homo sapiens
3 SKP1 6500
Affinity Capture-MS Homo sapiens
4 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TFCP2 7024
Two-hybrid Homo sapiens
6 PSMA3 5684
Two-hybrid Homo sapiens
7 NEDD4 4734
Affinity Capture-Western Homo sapiens
8 RBPMS 11030
Two-hybrid Homo sapiens
9 FBXL7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
10 WWP1 11059
Two-hybrid Homo sapiens
11 TRAF4 9618
Two-hybrid Homo sapiens
12 Skp1a 21402
Affinity Capture-MS Mus musculus
13 FBXL16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 PLSCR1 5359
Two-hybrid Homo sapiens
15 CHMP1A 5119
Co-fractionation Homo sapiens
16 MAGEA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MDFI  
Two-hybrid Homo sapiens
18 FHL3 2275
Two-hybrid Homo sapiens
19 RBX1 9978
Affinity Capture-MS Homo sapiens
20 ZNF207 7756
Co-fractionation Homo sapiens
21 WWP2 11060
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
23 KRTAP10-3  
Two-hybrid Homo sapiens
24 DUSP16  
Affinity Capture-MS Homo sapiens
25 HNRNPK 3190
Two-hybrid Homo sapiens
26 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
27 GOLGA2 2801
Two-hybrid Homo sapiens
28 ACSF3 197322
Affinity Capture-Western Homo sapiens
29 PSTPIP1 9051
Two-hybrid Homo sapiens
30 PNMA1 9240
Two-hybrid Homo sapiens
31 C12orf49  
Negative Genetic Homo sapiens
32 EZH2  
Affinity Capture-MS Homo sapiens
33 NTRK1 4914
Affinity Capture-MS Homo sapiens
34 COPS6 10980
Affinity Capture-MS Homo sapiens
35 PARK2  
Affinity Capture-MS Homo sapiens
36 COPS5 10987
Affinity Capture-MS Homo sapiens
37 KRT40  
Two-hybrid Homo sapiens
38 TTC9C 283237
Affinity Capture-MS Homo sapiens
39 TBL1Y  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 MOCS3 27304
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CALCOCO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
42 IRGC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 MTUS2 23281
Two-hybrid Homo sapiens
44 SKP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ATG7 10533
Affinity Capture-MS Homo sapiens
47 MID2 11043
Two-hybrid Homo sapiens
48 GNA11 2767
Affinity Capture-MS Homo sapiens
49 BRD4 23476
Affinity Capture-MS Homo sapiens
50 TRAF1 7185
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here