Gene description for Skp1a
Gene name S-phase kinase-associated protein 1A
Gene symbol Skp1a
Other names/aliases 15kDa
2610043E24Rik
2610206H23Rik
EMC19
OCP-II
OCP2
SKP1
Tceb1l
p19A
p19Skp1
Species Mus musculus
 Database cross references - Skp1a
ExoCarta ExoCarta_21402
Entrez Gene 21402
UniProt Q9WTX5  
 Skp1a identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Skp1a
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-protein transferase activity GO:0004842 ISO
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IC
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISO
    histone H2A monoubiquitination GO:0035518 ISO
    protein ubiquitination GO:0016567 ISO
Subcellular Localization
    Cul7-RING ubiquitin ligase complex GO:0031467 ISO
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 IDA
    PcG protein complex GO:0031519 ISO
    SCF ubiquitin ligase complex GO:0019005 ISO
 Experiment description of studies that identified Skp1a in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Skp1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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