Gene description for Cops8
Gene name COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
Gene symbol Cops8
Other names/aliases 9430009J09Rik
Species Mus musculus
 Database cross references - Cops8
ExoCarta ExoCarta_108679
Entrez Gene 108679
UniProt Q8VBV7  
 Cops8 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Cops8
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of cell proliferation GO:0008285 ISO
    activation of NF-kappaB-inducing kinase activity GO:0007250 ISO
    cullin deneddylation GO:0010388 ISO
Subcellular Localization
    COP9 signalosome GO:0008180 ISO
    nucleoplasm GO:0005654 ISO
    extracellular exosome GO:0070062 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Cops8 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cops8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cops8 is involved
No pathways found

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