Gene description for Cops2
Gene name COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)
Gene symbol Cops2
Other names/aliases AI315723
Species Mus musculus
 Database cross references - Cops2
ExoCarta ExoCarta_12848
Entrez Gene 12848
UniProt P61202  
 Cops2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Cops2
Molecular Function
    transcription corepressor activity GO:0003714 IDA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of nucleic acid-templated transcription GO:1903507 ISO
    cell proliferation GO:0008283 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    neuron differentiation GO:0030182 ISO
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    skeletal muscle cell differentiation GO:0035914 IMP
Subcellular Localization
    COP9 signalosome GO:0008180 IDA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Cops2 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cops2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cops2 is involved
No pathways found

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