Gene description for Ctnnb1
Gene name catenin (cadherin associated protein), beta 1
Gene symbol Ctnnb1
Other names/aliases Bfc
Catnb
Mesc
Species Mus musculus
 Database cross references - Ctnnb1
ExoCarta ExoCarta_12387
Vesiclepedia VP_12387
Entrez Gene 12387
UniProt Q02248  
 Ctnnb1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ctnnb1
Molecular Function
    ionotropic glutamate receptor binding GO:0035255 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    RNA polymerase II activating transcription factor binding GO:0001102 ISO
    SMAD binding GO:0046332 ISO
    signal transducer activity GO:0004871 IEA
    repressing transcription factor binding GO:0070491 IPI
    chromatin binding GO:0003682 IGI
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    alpha-catenin binding GO:0045294 ISO
    double-stranded DNA binding GO:0003690 IDA
    nuclear hormone receptor binding GO:0035257 ISO
    transcription factor binding GO:0008134 ISO
    R-SMAD binding GO:0070412 ISO
    I-SMAD binding GO:0070411 ISO
    nitric-oxide synthase binding GO:0050998 ISO
    protein complex binding GO:0032403 ISO
    estrogen receptor binding GO:0030331 ISO
    protein C-terminus binding GO:0008022 ISO
    protein phosphatase binding GO:0019903 ISO
    enzyme binding GO:0019899 ISO
    cadherin binding GO:0045296 ISO
    kinase binding GO:0019900 ISO
    transcription regulatory region DNA binding GO:0044212 ISO
    transcription coactivator activity GO:0003713 ISO
    ion channel binding GO:0044325 ISO
    euchromatin binding GO:1990188 ISO
Biological Process
    bone resorption GO:0045453 IMP
    negative regulation of chondrocyte differentiation GO:0032331 IGI
    trachea morphogenesis GO:0060439 IMP
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 IMP
    cell adhesion GO:0007155 ISO
    positive regulation of cell proliferation GO:0008284 IMP
    anterior/posterior axis specification GO:0009948 IMP
    cell differentiation GO:0030154 IMP
    response to cytokine GO:0034097 ISO
    epithelial tube branching involved in lung morphogenesis GO:0060441 IMP
    ectoderm development GO:0007398 IMP
    cellular protein localization GO:0034613 IMP
    cellular response to indole-3-methanol GO:0071681 ISO
    heart development GO:0007507 IMP
    hair follicle placode formation GO:0060789 IMP
    proximal/distal pattern formation GO:0009954 IMP
    epicardium-derived cardiac vascular smooth muscle cell differentiation GO:0060983 TAS
    organ development GO:0048513 IMP
    hair cycle process GO:0022405 IMP
    positive regulation of gene expression GO:0010628 IMP
    glial cell fate determination GO:0007403 IDA
    regulation of transcription, DNA-templated GO:0006355 IDA
    odontogenesis of dentin-containing tooth GO:0042475 IMP
    oviduct development GO:0060066 IMP
    epithelial cell differentiation involved in prostate gland development GO:0060742 IMP
    metanephros morphogenesis GO:0003338 IMP
    positive regulation of MAPK cascade GO:0043410 IGI
    embryonic hindlimb morphogenesis GO:0035116 IMP
    cellular response to insulin-like growth factor stimulus GO:1990314 ISO
    response to estradiol GO:0032355 ISO
    cardiac vascular smooth muscle cell differentiation GO:0060947 TAS
    negative regulation of apoptotic signaling pathway GO:2001234 IMP
    mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 IDA
    trachea formation GO:0060440 IMP
    protein heterooligomerization GO:0051291 ISO
    negative regulation of mitotic cell cycle, embryonic GO:0045976 IMP
    positive regulation of endothelial cell differentiation GO:0045603 IMP
    morphogenesis of embryonic epithelium GO:0016331 IMP
    osteoclast differentiation GO:0030316 IMP
    negative regulation of protein sumoylation GO:0033234 ISO
    dorsal/ventral axis specification GO:0009950 IMP
    layer formation in cerebral cortex GO:0021819 IMP
    Wnt signaling pathway GO:0016055 ISO
    regulation of cell differentiation GO:0045595 IDA
    cellular response to organic cyclic compound GO:0071407 IDA
    regulation of secondary heart field cardioblast proliferation GO:0003266 IDA
    vasculature development GO:0001944 IMP
    nephron tubule formation GO:0072079 IMP
    dorsal/ventral pattern formation GO:0009953 IMP
    mesenchyme morphogenesis GO:0072132 TAS
    genitalia morphogenesis GO:0035112 IMP
    synaptic transmission GO:0007268 IMP
    patterning of blood vessels GO:0001569 IMP
    regulation of gene expression GO:0010468 IMP
    embryonic skeletal limb joint morphogenesis GO:0036023 IGI
    positive regulation of heparan sulfate proteoglycan biosynthetic process GO:0010909 ISO
    cell fate determination GO:0001709 IMP
    ventricular compact myocardium morphogenesis GO:0003223 TAS
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    cell morphogenesis involved in differentiation GO:0000904 IMP
    regulation of osteoblast differentiation GO:0045667 IMP
    cell proliferation GO:0008283 IMP
    negative regulation of osteoclast differentiation GO:0045671 IMP
    endothelial tube morphogenesis GO:0061154 ISO
    regulation of transcription from RNA polymerase II promoter GO:0006357 IMP
    regulation of centromeric sister chromatid cohesion GO:0070602 ISO
    positive regulation of mesenchymal cell proliferation GO:0002053 IMP
    neuron migration GO:0001764 IGI
    chromatin-mediated maintenance of transcription GO:0048096 IMP
    mesenchyme development GO:0060485 TAS
    canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition GO:0044334 ISO
    limb development GO:0060173 IMP
    nervous system development GO:0007399 IEA
    renal system development GO:0072001 IMP
    regulation of nephron tubule epithelial cell differentiation GO:0072182 IMP
    mesenchymal cell proliferation involved in lung development GO:0060916 IMP
    synapse organization GO:0050808 IMP
    hemopoiesis GO:0030097 IDA
    fungiform papilla formation GO:0061198 IMP
    vasculogenesis GO:0001570 IMP
    coronary artery morphogenesis GO:0060982 TAS
    canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    sympathetic ganglion development GO:0061549 IMP
    protein localization to cell surface GO:0034394 ISO
    kidney development GO:0001822 IMP
    embryonic digit morphogenesis GO:0042733 IMP
    positive regulation of telomerase activity GO:0051973 IMP
    response to estrogen GO:0043627 ISO
    regulation of smooth muscle cell proliferation GO:0048660 ISO
    stem cell maintenance GO:0019827 TAS
    negative regulation of cell differentiation GO:0045596 IMP
    negative regulation of neuron death GO:1901215 IGI
    in utero embryonic development GO:0001701 IMP
    regulation of centriole-centriole cohesion GO:0030997 ISO
    regulation of apoptotic process GO:0042981 IMP
    branching involved in ureteric bud morphogenesis GO:0001658 IMP
    oocyte development GO:0048599 IGI
    neural plate development GO:0001840 IDA
    lens morphogenesis in camera-type eye GO:0002089 IMP
    cellular process GO:0009987 IDA
    regulation of cell proliferation GO:0042127 IMP
    positive regulation of branching involved in lung morphogenesis GO:0061047 IMP
    regulation of cell fate specification GO:0042659 IBA
    central nervous system vasculogenesis GO:0022009 IMP
    embryonic foregut morphogenesis GO:0048617 IMP
    renal inner medulla development GO:0072053 IMP
    regulation of epithelial cell differentiation GO:0030856 IMP
    canonical Wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 ISO
    skeletal system development GO:0001501 IMP
    cell fate specification GO:0001708 IMP
    positive regulation of epithelial to mesenchymal transition GO:0010718 TAS
    cell-matrix adhesion GO:0007160 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    positive regulation of neuroblast proliferation GO:0002052 IMP
    thymus development GO:0048538 IMP
    positive regulation of osteoblast differentiation GO:0045669 IMP
    synaptic vesicle transport GO:0048489 IMP
    lung cell differentiation GO:0060479 IMP
    lung induction GO:0060492 IMP
    gastrulation with mouth forming second GO:0001702 IMP
    lung-associated mesenchyme development GO:0060484 IMP
    positive regulation of determination of dorsal identity GO:2000017 IDA
    lung development GO:0030324 IMP
    canonical Wnt signaling pathway GO:0060070 ISO
    positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 IMP
    regulation of protein localization to cell surface GO:2000008 ISO
    cardiac muscle cell proliferation GO:0060038 TAS
    smooth muscle cell differentiation GO:0051145 IMP
    renal outer medulla development GO:0072054 IMP
    forebrain development GO:0030900 IMP
    single organismal cell-cell adhesion GO:0016337 ISO
    regulation of myelination GO:0031641 IMP
    T cell differentiation in thymus GO:0033077 IMP
    endodermal cell fate commitment GO:0001711 IMP
    negative regulation of oligodendrocyte differentiation GO:0048715 IMP
    endoderm formation GO:0001706 IMP
    renal vesicle formation GO:0072033 IMP
    cell maturation GO:0048469 IMP
    positive regulation of apoptotic process GO:0043065 ISO
    hair follicle morphogenesis GO:0031069 IMP
    embryonic forelimb morphogenesis GO:0035115 IDA
    regulation of calcium ion import GO:0090279 ISO
    embryonic heart tube development GO:0035050 IMP
    T cell differentiation GO:0030217 IMP
    negative regulation of cell proliferation GO:0008285 ISO
    regulation of T cell proliferation GO:0042129 IMP
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    adherens junction assembly GO:0034333 ISO
    transcription, DNA-templated GO:0006351 IEA
    Schwann cell proliferation GO:0014010 ISO
    cellular response to growth factor stimulus GO:0071363 ISO
    cellular response to mechanical stimulus GO:0071260 ISO
    positive regulation of epithelial cell differentiation GO:0030858 IMP
    adherens junction organization GO:0034332 IMP
    skin development GO:0043588 IMP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IMP
    positive regulation of telomere maintenance via telomerase GO:0032212 IMP
    regulation of osteoclast differentiation GO:0045670 IMP
    male genitalia development GO:0030539 IMP
    pancreas development GO:0031016 IMP
    embryonic axis specification GO:0000578 IDA
Subcellular Localization
    lateral plasma membrane GO:0016328 ISO
    beta-catenin destruction complex GO:0030877 ISO
    dendritic shaft GO:0043198 ISO
    beta-catenin-TCF7L2 complex GO:0070369 ISO
    cell projection membrane GO:0031253 IDA
    bicellular tight junction GO:0005923 IDA
    Scrib-APC-beta-catenin complex GO:0034750 IDA
    basolateral plasma membrane GO:0016323 IDA
    cytoskeleton GO:0005856 IEA
    adherens junction GO:0005912 ISO
    protein-DNA complex GO:0032993 ISO
    protein complex GO:0043234 ISO
    cell periphery GO:0071944 ISO
    lamellipodium GO:0030027 IDA
    cytoplasm GO:0005737 ISO
    synapse GO:0045202 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    cell-cell junction GO:0005911 ISO
    microvillus membrane GO:0031528 IDA
    catenin complex GO:0016342 ISO
    cell cortex GO:0005938 ISO
    intercalated disc GO:0014704 IDA
    membrane GO:0016020 ISO
    focal adhesion GO:0005925 ISO
    centrosome GO:0005813 ISO
    neuron projection GO:0043005 ISO
    Z disc GO:0030018 IDA
    catenin-TCF7L2 complex GO:0071664 IDA
    apical part of cell GO:0045177 IDA
    nuclear euchromatin GO:0005719 ISO
    cell junction GO:0030054 ISO
    transcription factor complex GO:0005667 ISO
    nucleus GO:0005634 ISO
    cytosol GO:0005829 ISO
    nuclear transcription factor complex GO:0044798 IDA
    extracellular exosome GO:0070062 ISO
    apical junction complex GO:0043296 IDA
    cell GO:0005623 IMP
    fascia adherens GO:0005916 IDA
    plasma membrane GO:0005886 ISO
    cell-cell adherens junction GO:0005913 ISO
 Experiment description of studies that identified Ctnnb1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ctnnb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MUC1 4582
Affinity Capture-Western Homo sapiens
2 PIK3R1 5295
Affinity Capture-Western Homo sapiens
3 Ptprf  
Affinity Capture-Western Mus musculus
4 PSEN1 5663
Affinity Capture-Western Homo sapiens
5 TAX1BP3 30851
Reconstituted Complex Homo sapiens
6 Acp1 11431
Affinity Capture-Western Mus musculus
7 N/A  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
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