Gene description for Tcf4
Gene name transcription factor 4
Gene symbol Tcf4
Other names/aliases 5730422P05Rik
ASP-I2
E2-2
E2.2
ITF-2
ITF-2b
ITF2
ME2
MITF-2A
MITF-2B
SEF-2
SEF2
SEF2-1
TFE
Tcf-4
bHLHb19
Species Mus musculus
 Database cross references - Tcf4
ExoCarta ExoCarta_21413
Entrez Gene 21413
UniProt Q60722  
 Tcf4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tcf4
Molecular Function
    protein homodimerization activity GO:0042803 IBA
    TFIIB-class binding transcription factor activity GO:0001087 IDA
    sequence-specific DNA binding RNA polymerase recruiting transcription factor activity GO:0001011 IDA
    bHLH transcription factor binding GO:0043425 ISO
    transcription corepressor activity GO:0003714 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    protein dimerization activity GO:0046983 IEA
    protein binding GO:0005515 IPI
    chromatin binding GO:0003682 IDA
    protein heterodimerization activity GO:0046982 IDA
    DNA binding GO:0003677 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    double-stranded DNA binding GO:0003690 ISO
    protein C-terminus binding GO:0008022 ISO
    TFIIB-class transcription factor binding GO:0001093 IDA
    E-box binding GO:0070888 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
Biological Process
    nervous system development GO:0007399 IEA
    protein-DNA complex assembly GO:0065004 IDA
    cell differentiation GO:0030154 IEA
    regulation of transcription, DNA-templated GO:0006355 IDA
    multicellular organismal development GO:0007275 IEA
    DNA-templated transcription, initiation GO:0006352 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    positive regulation of neuron differentiation GO:0045666 IDA
    transcription, DNA-templated GO:0006351 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    positive regulation of transcription, DNA-templated GO:0045893 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    transcription factor complex GO:0005667 IDA
 Experiment description of studies that identified Tcf4 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tcf4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Id3  
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which Tcf4 is involved
No pathways found





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