Gene description for Tcf12
Gene name transcription factor 12
Gene symbol Tcf12
Other names/aliases A130037E08Rik
ALF1
HEB
HEBAlt
HTF-4
HTF4
ME1
REB
bHLHb20
Species Mus musculus
 Database cross references - Tcf12
ExoCarta ExoCarta_21406
Entrez Gene 21406
UniProt Q61286  
 Tcf12 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tcf12
Molecular Function
    E-box binding GO:0070888 IDA
    protein heterodimerization activity GO:0046982 IDA
    protein homodimerization activity GO:0042803 IBA
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 ISO
    bHLH transcription factor binding GO:0043425 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
    DNA binding GO:0003677 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 ISO
    protein dimerization activity GO:0046983 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    SMAD binding GO:0046332 ISO
    HMG box domain binding GO:0071837 ISO
    transcription regulatory region DNA binding GO:0044212 ISO
    cAMP response element binding GO:0035497 ISO
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription from RNA polymerase II promoter GO:0006366 ISO
    transcription, DNA-templated GO:0006351 IEA
    cell differentiation GO:0030154 IEA
    positive regulation of neuron differentiation GO:0045666 IDA
    nervous system development GO:0007399 IEA
    multicellular organismal development GO:0007275 IEA
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    positive regulation of transcription, DNA-templated GO:0045893 IDA
Subcellular Localization
    transcription factor complex GO:0005667 IDA
    cytoplasm GO:0005737 ISO
    RNA polymerase II transcription factor complex GO:0090575 ISO
    nucleus GO:0005634 ISO
    nuclear chromatin GO:0000790 ISO
 Experiment description of studies that identified Tcf12 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tcf12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Id3  
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
View the network image/svg+xml
 Pathways in which Tcf12 is involved
No pathways found





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