Gene description for Lef1
Gene name	lymphoid enhancer binding factor 1
Gene symbol	Lef1
Other names/aliases	3000002B05 AI451430 Lef-1
Species	Mus musculus
Database cross references - Lef1
ExoCarta	ExoCarta_16842
Vesiclepedia	VP_16842
Entrez Gene	16842
UniProt	P27782
Lef1 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Lef1

Molecular Function     transcription cis-regulatory region binding GO:0000976 IDA     RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 ISO     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IGI     cis-regulatory region sequence-specific DNA binding GO:0000987 IDA     transcription corepressor binding GO:0001222 IEA     transcription corepressor binding GO:0001222 ISO     DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IMP     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO     nucleic acid binding GO:0003676 EXP     DNA binding GO:0003677 IDA     chromatin binding GO:0003682 IDA     DNA-binding transcription factor activity GO:0003700 IDA     DNA-binding transcription factor activity GO:0003700 ISO     protein binding GO:0005515 IPI     beta-catenin binding GO:0008013 IEA     beta-catenin binding GO:0008013 ISO     transcription factor binding GO:0008134 IPI     DNA binding, bending GO:0008301 EXP     DNA binding, bending GO:0008301 IDA     nuclear estrogen receptor binding GO:0030331 IEA     nuclear estrogen receptor binding GO:0030331 ISO     histone binding GO:0042393 ISO     histone deacetylase binding GO:0042826 IEA     histone deacetylase binding GO:0042826 ISO     sequence-specific DNA binding GO:0043565 IDA     sequence-specific DNA binding GO:0043565 ISO     gamma-catenin binding GO:0045295 IEA     gamma-catenin binding GO:0045295 ISO     armadillo repeat domain binding GO:0070016 IEA     armadillo repeat domain binding GO:0070016 ISO     C2H2 zinc finger domain binding GO:0070742 IEA     C2H2 zinc finger domain binding GO:0070742 ISO     transcription regulator inhibitor activity GO:0140416 IEA     sequence-specific double-stranded DNA binding GO:1990837 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     branching involved in blood vessel morphogenesis GO:0001569 IMP     osteoblast differentiation GO:0001649 IEA     somitogenesis GO:0001756 IGI     somitogenesis GO:0001756 IMP     epithelial to mesenchymal transition GO:0001837 IMP     vasculature development GO:0001944 IMP     sprouting angiogenesis GO:0002040 IMP     regulation of DNA-templated transcription GO:0006355 IMP     regulation of transcription by RNA polymerase II GO:0006357 IBA     regulation of transcription by RNA polymerase II GO:0006357 IDA     transcription by RNA polymerase II GO:0006366 IMP     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     positive regulation of epithelial to mesenchymal transition GO:0010718 IEA     positive regulation of epithelial to mesenchymal transition GO:0010718 ISO     dentate gyrus development GO:0021542 IMP     hippocampus development GO:0021766 IMP     forebrain radial glial cell differentiation GO:0021861 IGI     forebrain neuroblast division GO:0021873 IGI     formation of radial glial scaffolds GO:0021943 IGI     regulation of cell-cell adhesion GO:0022407 IMP     regulation of Wnt signaling pathway GO:0030111 IGI     positive regulation of Wnt signaling pathway GO:0030177 IMP     neutrophil differentiation GO:0030223 IEA     neutrophil differentiation GO:0030223 ISO     embryonic limb morphogenesis GO:0030326 IGI     positive regulation of cell migration GO:0030335 IEA     positive regulation of cell migration GO:0030335 ISO     BMP signaling pathway GO:0030509 IDA     positive regulation of granulocyte differentiation GO:0030854 IEA     positive regulation of granulocyte differentiation GO:0030854 ISO     mammary gland development GO:0030879 IMP     negative regulation of interleukin-13 production GO:0032696 IEA     negative regulation of interleukin-13 production GO:0032696 ISO     negative regulation of interleukin-4 production GO:0032713 IEA     negative regulation of interleukin-4 production GO:0032713 ISO     negative regulation of interleukin-5 production GO:0032714 IEA     negative regulation of interleukin-5 production GO:0032714 ISO     T cell receptor V(D)J recombination GO:0033153 IGI     B cell proliferation GO:0042100 IMP     odontogenesis of dentin-containing tooth GO:0042475 IGI     odontogenesis of dentin-containing tooth GO:0042475 IMP     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of DNA binding GO:0043392 ISO     tongue development GO:0043586 IMP     positive regulation by host of viral transcription GO:0043923 IEA     positive regulation by host of viral transcription GO:0043923 ISO     T-helper 1 cell differentiation GO:0045063 IDA     positive regulation of gamma-delta T cell differentiation GO:0045588 IMP     positive regulation of cell differentiation GO:0045597 NAS     negative regulation of striated muscle tissue development GO:0045843 IDA     negative regulation of DNA-templated transcription GO:0045892 IDA     negative regulation of DNA-templated transcription GO:0045892 ISO     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IGI     positive regulation of transcription by RNA polymerase II GO:0045944 IGI     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     alpha-beta T cell differentiation GO:0046632 IGI     paraxial mesoderm formation GO:0048341 IGI     cell development GO:0048468 IGI     regulation of neurogenesis GO:0050767 NAS     sensory perception of taste GO:0050909 IMP     anatomical structure regression GO:0060033 IMP     canonical Wnt signaling pathway GO:0060070 IBA     canonical Wnt signaling pathway GO:0060070 IDA     canonical Wnt signaling pathway GO:0060070 IGI     canonical Wnt signaling pathway GO:0060070 IMP     canonical Wnt signaling pathway GO:0060070 ISO     face morphogenesis GO:0060325 IGI     cell chemotaxis GO:0060326 IEA     cell chemotaxis GO:0060326 ISO     apoptotic process involved in morphogenesis GO:0060561 IMP     chorio-allantoic fusion GO:0060710 IGI     trachea gland development GO:0061153 IMP     secondary palate development GO:0062009 IMP     protein localization to chromatin GO:0071168 IEA     protein localization to chromatin GO:0071168 ISO     cellular response to cytokine stimulus GO:0071345 ISO     cellular response to interleukin-4 GO:0071353 IEA     cellular response to interleukin-4 GO:0071353 ISO     positive regulation of cell proliferation in bone marrow GO:0071864 IEA     positive regulation of cell proliferation in bone marrow GO:0071864 ISO     negative regulation of apoptotic process in bone marrow cell GO:0071866 IEA     negative regulation of apoptotic process in bone marrow cell GO:0071866 ISO     odontoblast differentiation GO:0071895 ISO     positive regulation of cell cycle process GO:0090068 ISO     positive regulation of odontoblast differentiation GO:1901331 IMP     apoptotic process involved in blood vessel morphogenesis GO:1902262 IMP     positive regulation of chondrocyte proliferation GO:1902732 IMP     epithelial cell apoptotic process GO:1904019 IMP Subcellular Localization     chromatin GO:0000785 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 IPI     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 TAS     transcription regulator complex GO:0005667 IDA     transcription regulator complex GO:0005667 IPI     transcription regulator complex GO:0005667 ISO     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     protein-DNA complex GO:0032993 IEA     protein-DNA complex GO:0032993 ISO     RNA polymerase II transcription regulator complex GO:0090575 IPI     beta-catenin-TCF complex GO:1990907 IBA     beta-catenin-TCF complex GO:1990907 IDA     beta-catenin-TCF complex GO:1990907 ISO