Gene description for Tdg
Gene name	thymine DNA glycosylase
Gene symbol	Tdg
Other names/aliases	E130317C12Rik JZA-3 Jza1
Species	Mus musculus
Database cross references - Tdg
ExoCarta	ExoCarta_21665
Vesiclepedia	VP_21665
Entrez Gene	21665
UniProt	P56581
Tdg identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Tdg

Molecular Function     magnesium ion binding GO:0000287 IEA     magnesium ion binding GO:0000287 ISO     nucleic acid binding GO:0003676 ISO     DNA binding GO:0003677 IDA     double-stranded DNA binding GO:0003690 ISO     double-stranded DNA binding GO:0003690 ISS     transcription coregulator activity GO:0003712 IGI     uracil DNA N-glycosylase activity GO:0004844 IBA     uracil DNA N-glycosylase activity GO:0004844 ISO     protein kinase C binding GO:0005080 IPI     protein binding GO:0005515 IPI     protein binding GO:0005515 ISS     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263 IBA     pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263 ISO     DNA N-glycosylase activity GO:0019104 IDA     DNA N-glycosylase activity GO:0019104 ISO     protein domain specific binding GO:0019904 IEA     protein domain specific binding GO:0019904 ISO     mismatched DNA binding GO:0030983 ISO     mismatched DNA binding GO:0030983 ISS     sodium ion binding GO:0031402 IEA     sodium ion binding GO:0031402 ISO     chloride ion binding GO:0031404 IEA     chloride ion binding GO:0031404 ISO     SUMO binding GO:0032183 IPI     SUMO binding GO:0032183 ISO     G/U mismatch-specific uracil-DNA glycosylase activity GO:0043739 IEA     G/U mismatch-specific uracil-DNA glycosylase activity GO:0043739 ISO     DNA-binding transcription factor binding GO:0140297 IEA     DNA-binding transcription factor binding GO:0140297 ISO     G/T mismatch-specific thymine-DNA glycosylase activity GO:0141016 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IGI     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     base-excision repair GO:0006284 IDA     base-excision repair GO:0006284 ISO     base-excision repair GO:0006284 ISS     base-excision repair, AP site formation GO:0006285 IBA     base-excision repair, AP site formation GO:0006285 IEA     negative regulation of protein binding GO:0032091 IDA     negative regulation of chromatin binding GO:0035562 IDA     epigenetic regulation of gene expression GO:0040029 IMP     regulation of embryonic development GO:0045995 IMP Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 ISO     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     PML body GO:0016605 IDA