Gene description for Tdg
Gene name thymine DNA glycosylase
Gene symbol Tdg
Other names/aliases E130317C12Rik
JZA-3
Jza1
Species Mus musculus
 Database cross references - Tdg
ExoCarta ExoCarta_21665
Entrez Gene 21665
UniProt P56581  
 Tdg identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tdg
Molecular Function
    protein kinase C binding GO:0005080 IPI
    protein binding GO:0005515 IPI
    hydrolase activity, acting on glycosyl bonds GO:0016798 IEA
    SUMO binding GO:0032183 IPI
    transcription factor binding GO:0008134 ISO
    RNA polymerase II transcription cofactor activity GO:0001104 IGI
    pyrimidine-specific mismatch base pair DNA N-glycosylase activity GO:0008263 ISO
    DNA N-glycosylase activity GO:0019104 ISO
    hydrolase activity GO:0016787 IEA
    hydrolase activity, hydrolyzing N-glycosyl compounds GO:0016799 IEA
    mismatched DNA binding GO:0030983 ISO
    double-stranded DNA binding GO:0003690 ISO
    structure-specific DNA binding GO:0043566 IDA
    protein homodimerization activity GO:0042803 ISO
    protein domain specific binding GO:0019904 ISO
Biological Process
    mismatch repair GO:0006298 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    regulation of gene expression, epigenetic GO:0040029 IMP
    metabolic process GO:0008152 IEA
    base-excision repair GO:0006284 ISO
    DNA demethylation GO:0080111 IMP
    embryo development GO:0009790 IMP
    cellular response to DNA damage stimulus GO:0006974 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of protein binding GO:0032091 IDA
    transcription from RNA polymerase II promoter GO:0006366 IGI
    chromatin modification GO:0016568 IEA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of chromatin binding GO:0035562 IDA
    DNA repair GO:0006281 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    PML body GO:0016605 IDA
    nucleoplasm GO:0005654 ISO
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Tdg in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tdg
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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