Gene description for DNMT3A
Gene name	DNA (cytosine-5-)-methyltransferase 3 alpha
Gene symbol	DNMT3A
Other names/aliases	DNMT3A2 M.HsaIIIA TBRS
Species	Homo sapiens
Database cross references - DNMT3A
ExoCarta	ExoCarta_1788
Entrez Gene	1788
HGNC	2978
MIM	602769
UniProt	Q9Y6K1
DNMT3A identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for DNMT3A

Molecular Function     DNA (cytosine-5-)-methyltransferase activity GO:0003886 IDA     protein binding GO:0005515 IPI     DNA binding GO:0003677 IDA     DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates GO:0051718 IEA     chromatin binding GO:0003682 IEA     identical protein binding GO:0042802 IPI     unmethylated CpG binding GO:0045322 IEA     metal ion binding GO:0046872 IEA     DNA-methyltransferase activity GO:0009008 TAS Biological Process     C-5 methylation of cytosine GO:0090116 IEA     hypermethylation of CpG island GO:0044027 IEA     S-adenosylmethioninamine metabolic process GO:0046499 IEA     regulation of gene expression, epigenetic GO:0040029 TAS     regulation of gene expression by genetic imprinting GO:0006349 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     negative regulation of gene expression, epigenetic GO:0045814 TAS     DNA methylation on cytosine GO:0032776 TAS     S-adenosylhomocysteine metabolic process GO:0046498 IEA     methylation-dependent chromatin silencing GO:0006346 IEA     chromatin organization GO:0006325 TAS     DNA methylation on cytosine within a CG sequence GO:0010424 IEA     DNA methylation involved in embryo development GO:0043045 IEA     gene expression GO:0010467 TAS     DNA methylation involved in gamete generation GO:0043046 IEA     cellular response to amino acid stimulus GO:0071230 IEA     spermatogenesis GO:0007283 IEA     DNA methylation GO:0006306 IDA Subcellular Localization     cytoplasm GO:0005737 IDA     euchromatin GO:0000791 IDA     nuclear heterochromatin GO:0005720 IEA     nuclear matrix GO:0016363 IDA     nucleus GO:0005634 IDA     chromosome, centromeric region GO:0000775 IEA     nucleoplasm GO:0005654 TAS     XY body GO:0001741 IEA