Gene description for EHMT2
Gene name euchromatic histone-lysine N-methyltransferase 2
Gene symbol EHMT2
Other names/aliases BAT8
C6orf30
G9A
GAT8
KMT1C
NG36
Species Homo sapiens
 Database cross references - EHMT2
ExoCarta ExoCarta_10919
Vesiclepedia VP_10919
Entrez Gene 10919
HGNC 14129
MIM 604599
UniProt Q96KQ7  
 EHMT2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for EHMT2
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IEA
    transcription corepressor binding GO:0001222 IPI
    p53 binding GO:0002039 IPI
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    protein-lysine N-methyltransferase activity GO:0016279 IDA
    histone H3K9 methyltransferase activity GO:0046974 IBA
    histone H3K9 methyltransferase activity GO:0046974 ISS
    histone H3K27 methyltransferase activity GO:0046976 ISS
    C2H2 zinc finger domain binding GO:0070742 IPI
    histone H3K56 methyltransferase activity GO:0140759 IMP
    histone H3K9me2 methyltransferase activity GO:0140947 IEA
    promoter-specific chromatin binding GO:1990841 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of DNA replication GO:0006275 IMP
    DNA methylation-dependent constitutive heterochromatin formation GO:0006346 ISS
    synaptonemal complex assembly GO:0007130 IEA
    spermatid development GO:0007286 IEA
    long-term memory GO:0007616 IEA
    cellular response to starvation GO:0009267 IDA
    fertilization GO:0009566 IEA
    peptidyl-lysine dimethylation GO:0018027 IDA
    regulation of protein modification process GO:0031399 IEA
    organ growth GO:0035265 IEA
    phenotypic switching GO:0036166 IEA
    epigenetic regulation of gene expression GO:0040029 IBA
    negative regulation of gene expression via chromosomal CpG island methylation GO:0044027 IEA
    response to ethanol GO:0045471 IEA
    behavioral response to cocaine GO:0048148 IEA
    oocyte development GO:0048599 IEA
    neuron fate specification GO:0048665 IEA
    response to fungicide GO:0060992 IEA
    cellular response to cocaine GO:0071314 IEA
    cellular response to xenobiotic stimulus GO:0071466 IEA
    negative regulation of autophagosome assembly GO:1902902 IEA
Subcellular Localization
    chromatin GO:0000785 IBA
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nuclear speck GO:0016607 IDA
 Experiment description of studies that identified EHMT2 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for EHMT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZBTB38 253461
Two-hybrid Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 HIST1H4K 8362
Affinity Capture-MS Homo sapiens
5 EXOSC7 23016
Two-hybrid Homo sapiens
6 KLF8  
Proximity Label-MS Homo sapiens
7 CBX1 10951
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
8 ZNF211  
Affinity Capture-MS Homo sapiens
9 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 COIL  
Proximity Label-MS Homo sapiens
11 DNAJC8 22826
Proximity Label-MS Homo sapiens
12 MIS12  
Affinity Capture-MS Homo sapiens
13 KLF9 687
Proximity Label-MS Homo sapiens
14 CTBP2 1488
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 POGZ 23126
Affinity Capture-MS Homo sapiens
16 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
17 NSL1  
Affinity Capture-MS Homo sapiens
18 LIMS1 3987
Two-hybrid Homo sapiens
19 RD3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 BRD2  
Affinity Capture-MS Homo sapiens
21 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
22 CDY2A  
Affinity Capture-MS Homo sapiens
23 GFI1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 ELF4 2000
Proximity Label-MS Homo sapiens
25 PMF1  
Affinity Capture-MS Homo sapiens
26 MYOD1  
Proximity Label-MS Homo sapiens
27 LMO2  
Two-hybrid Homo sapiens
28 EIF4ENIF1 56478
Two-hybrid Homo sapiens
29 PLOD3 8985
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
30 MX2 4600
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
31 TRIM28 10155
Affinity Capture-MS Homo sapiens
32 TFAM 7019
Proximity Label-MS Homo sapiens
33 DGCR14  
Two-hybrid Homo sapiens
34 CHAF1A  
Affinity Capture-MS Homo sapiens
35 JARID2  
Affinity Capture-Western Homo sapiens
36 RFXANK  
Affinity Capture-MS Homo sapiens
37 NAA11 84779
Two-hybrid Homo sapiens
38 HIST2H3A 333932
Biochemical Activity Homo sapiens
39 FBXW7  
Affinity Capture-MS Homo sapiens
40 LASP1 3927
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
41 HGS 9146
Two-hybrid Homo sapiens
42 CUX1 1523
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
43 KLF6  
Two-hybrid Homo sapiens
44 ZNF512B  
Two-hybrid Homo sapiens
45 POU5F1  
Affinity Capture-RNA Homo sapiens
46 SUV39H1  
Affinity Capture-MS Homo sapiens
47 POLR1E  
Proximity Label-MS Homo sapiens
48 TWIST2  
Affinity Capture-MS Homo sapiens
49 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TEAD1  
Proximity Label-MS Homo sapiens
51 GAGE2E 26749
Affinity Capture-MS Homo sapiens
52 RGS12 6002
Affinity Capture-MS Homo sapiens
53 EED  
Affinity Capture-MS Homo sapiens
54 FEV  
Proximity Label-MS Homo sapiens
55 ZNF644  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 E4F1  
Two-hybrid Homo sapiens
57 HIST1H4I 8294
Affinity Capture-MS Homo sapiens
58 ABHD17A 81926
Two-hybrid Homo sapiens
59 WIZ 58525
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
60 TLX3  
Proximity Label-MS Homo sapiens
61 KLF15  
Proximity Label-MS Homo sapiens
62 CSNK2B 1460
Affinity Capture-MS Homo sapiens
63 HIST1H3H 8357
Affinity Capture-MS Homo sapiens
64 MAD2L1 4085
Affinity Capture-MS Homo sapiens
65 ZNF462  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
66 GFI1B  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
67 TLX1  
Proximity Label-MS Homo sapiens
68 ESR1  
Reconstituted Complex Homo sapiens
69 PRH1  
Affinity Capture-MS Homo sapiens
70 MED30  
Affinity Capture-Western Homo sapiens
71 KLF16  
Proximity Label-MS Homo sapiens
72 Wiz  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
73 ZNF217 7764
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
74 H2AFZ 3015
Affinity Capture-MS Homo sapiens
75 PRPF6 24148
Two-hybrid Homo sapiens
76 HIST2H3C 126961
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
77 VEZF1  
Two-hybrid Homo sapiens
78 C10orf12  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 ATF7IP 55729
Two-hybrid Homo sapiens
80 PRDM1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
81 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
82 GAGE8  
Affinity Capture-MS Homo sapiens
83 SOX17  
Proximity Label-MS Homo sapiens
84 SCAI  
Affinity Capture-MS Homo sapiens
85 CTBP1 1487
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
86 CCDC33 80125
Two-hybrid Homo sapiens
87 SMEK1 55671
Co-fractionation Homo sapiens
88 NR0B2  
Affinity Capture-Western Homo sapiens
89 DNMT3A 1788
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
90 NFIX 4784
Proximity Label-MS Homo sapiens
91 ESCO2  
Affinity Capture-Western Homo sapiens
92 CBX3 11335
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
93 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
94 C12orf49  
Negative Genetic Homo sapiens
95 LHX1  
Proximity Label-MS Homo sapiens
96 MKRN2 23609
Affinity Capture-RNA Homo sapiens
97 TUBA1B 10376
Affinity Capture-MS Homo sapiens
98 LHX2  
Proximity Label-MS Homo sapiens
99 XAGE2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 ZNF837  
Two-hybrid Homo sapiens
101 ZBTB46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 LHX3  
Proximity Label-MS Homo sapiens
103 PPARD  
Affinity Capture-MS Homo sapiens
104 BANF1 8815
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
105 ACSM3  
Co-crystal Structure Homo sapiens
106 COPRS  
Affinity Capture-MS Homo sapiens
107 Hnrnpf 98758
Affinity Capture-MS Mus musculus
108 Mad2l2  
Affinity Capture-MS Mus musculus
109 PML 5371
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 GATA2  
Proximity Label-MS Homo sapiens
111 T  
Proximity Label-MS Homo sapiens
112 Bub1  
Affinity Capture-MS Mus musculus
113 KLF12  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
114 HSPB8 26353
Affinity Capture-MS Homo sapiens
115 VSX1  
Proximity Label-MS Homo sapiens
116 UBXN6 80700
Affinity Capture-MS Homo sapiens
117 DSN1 79980
Affinity Capture-MS Homo sapiens
118 TLX2  
Proximity Label-MS Homo sapiens
119 PAX6  
Proximity Label-MS Homo sapiens
120 MIER1  
Affinity Capture-MS Homo sapiens
121 HIST1H3C  
Biochemical Activity Bos taurus
122 CACNA1A  
Two-hybrid Homo sapiens
123 MAZ 4150
Two-hybrid Homo sapiens
124 HIST1H3A 8350
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
125 LHX6  
Affinity Capture-MS Homo sapiens
126 CUL3 8452
Affinity Capture-MS Homo sapiens
127 SMARCAD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
128 AHDC1  
Affinity Capture-MS Homo sapiens
129 RERE 473
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
130 SGOL1  
Affinity Capture-MS Homo sapiens
131 CBX5 23468
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
132 ELK3  
Proximity Label-MS Homo sapiens
133 FOXO1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
134 HIST1H1E 3008
Biochemical Activity Homo sapiens
Co-purification Homo sapiens
135 LHX4  
Proximity Label-MS Homo sapiens
136 TFAP4 7023
Affinity Capture-MS Homo sapiens
137 RICTOR 253260
Affinity Capture-MS Homo sapiens
138 UHRF2  
Affinity Capture-Western Homo sapiens
139 YY1 7528
Proximity Label-MS Homo sapiens
140 BRD3 8019
Affinity Capture-MS Homo sapiens
141 H3F3B 3021
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
142 ZNF223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 HIST3H3 8290
Biochemical Activity Homo sapiens
144 NXF1 10482
Affinity Capture-RNA Homo sapiens
145 CDY2B  
Affinity Capture-MS Homo sapiens
146 HIST1H3B 8358
Affinity Capture-MS Homo sapiens
147 CDYL 9425
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 HIST1H1A 3024
Biochemical Activity Homo sapiens
149 CHCHD2  
Two-hybrid Homo sapiens
150 RARRES1 5918
Affinity Capture-MS Homo sapiens
151 ESCO1  
Affinity Capture-Western Homo sapiens
152 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 SUV39H2 79723
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 EHMT2 10919
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
155 ETV3  
Proximity Label-MS Homo sapiens
156 MED23 9439
Affinity Capture-Western Homo sapiens
157 HIST1H3I 8354
Affinity Capture-MS Homo sapiens
158 RNF2  
Affinity Capture-MS Homo sapiens
159 SMC1A 8243
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
160 MECOM 2122
Affinity Capture-Western Homo sapiens
161 MIER2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 MYB  
Proximity Label-MS Homo sapiens
163 GRIP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
164 NAA10 8260
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
165 SOX2  
Proximity Label-MS Homo sapiens
166 Cbx1  
Affinity Capture-MS Mus musculus
167 NAPRT 93100
Two-hybrid Homo sapiens
168 ZNF414  
Affinity Capture-MS Homo sapiens
169 ZNF785  
Two-hybrid Homo sapiens
170 SIRT6  
Affinity Capture-MS Homo sapiens
171 Max  
Affinity Capture-MS Mus musculus
172 H3F3A 3020
Affinity Capture-MS Homo sapiens
173 TP53 7157
Biochemical Activity Homo sapiens
174 CDK8 1024
Affinity Capture-Western Homo sapiens
175 Ehmt1  
Affinity Capture-MS Mus musculus
176 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
177 SOX15  
Proximity Label-MS Homo sapiens
178 ZEB1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
179 KDM1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
180 KAT2B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
181 THAP7  
Two-hybrid Homo sapiens
182 CHAMP1  
Affinity Capture-MS Homo sapiens
183 KLF3  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
184 PTGER4  
Two-hybrid Homo sapiens
185 MED6  
Affinity Capture-Western Homo sapiens
186 HNF4A  
Proximity Label-MS Homo sapiens
187 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 CHD4 1108
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
189 ZNF764 92595
Affinity Capture-MS Homo sapiens
190 EIF4A3 9775
Two-hybrid Homo sapiens
191 PAX9  
Proximity Label-MS Homo sapiens
192 PRRC2B  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
193 PSMA1 5682
Two-hybrid Homo sapiens
194 XAGE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
195 PRDM5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
196 KLF5  
Proximity Label-MS Homo sapiens
197 ETV7  
Proximity Label-MS Homo sapiens
198 KDM1A 23028
Co-fractionation Homo sapiens
199 MED12  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
200 MOV10 4343
Affinity Capture-RNA Homo sapiens
201 EZH2  
Affinity Capture-MS Homo sapiens
202 HIC2 23119
Two-hybrid Homo sapiens
203 ZNF775  
Two-hybrid Homo sapiens
204 FAM161A  
Two-hybrid Homo sapiens
205 RELB  
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
206 MYOM2 9172
Affinity Capture-MS Homo sapiens
207 L3MBTL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
208 CEBPB  
Affinity Capture-Western Homo sapiens
209 EHMT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 ELF2  
Proximity Label-MS Homo sapiens
211 UHRF1 29128
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
212 NFIC 4782
Proximity Label-MS Homo sapiens
213 AR 367
Proximity Label-MS Homo sapiens
214 PCNA 5111
Co-fractionation Homo sapiens
215 ITGB5 3693
Two-hybrid Homo sapiens
216