Gene description for EHMT2
Gene name euchromatic histone-lysine N-methyltransferase 2
Gene symbol EHMT2
Other names/aliases BAT8
Species Homo sapiens
 Database cross references - EHMT2
ExoCarta ExoCarta_10919
Entrez Gene 10919
HGNC 14129
MIM 604599
UniProt Q96KQ7  
 EHMT2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for EHMT2
Molecular Function
    p53 binding GO:0002039 IPI
    C2H2 zinc finger domain binding GO:0070742 IPI
    histone methyltransferase activity (H3-K9 specific) GO:0046974 ISS
    protein binding GO:0005515 IPI
    histone methyltransferase activity (H3-K27 specific) GO:0046976 ISS
    protein-lysine N-methyltransferase activity GO:0016279 IDA
    histone-lysine N-methyltransferase activity GO:0018024 IMP
    zinc ion binding GO:0008270 IEA
Biological Process
    regulation of DNA replication GO:0006275 IMP
    histone H3-K9 methylation GO:0051567 ISS
    chromatin organization GO:0006325 TAS
    histone methylation GO:0016571 IMP
    histone H3-K27 methylation GO:0070734 ISS
    histone lysine methylation GO:0034968 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    peptidyl-lysine dimethylation GO:0018027 IDA
    DNA methylation GO:0006306 ISS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
    nucleus GO:0005634 ISS
    nuclear chromatin GO:0000790 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
 Experiment description of studies that identified EHMT2 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for EHMT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 H3F3B 3021
Two-hybrid Homo sapiens
2 KLF6  
Two-hybrid Homo sapiens
View the network image/svg+xml

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