Gene description for SUV39H2
Gene name suppressor of variegation 3-9 homolog 2 (Drosophila)
Gene symbol SUV39H2
Other names/aliases KMT1B
Species Homo sapiens
 Database cross references - SUV39H2
ExoCarta ExoCarta_79723
Entrez Gene 79723
HGNC 17287
MIM 606503
UniProt Q9H5I1  
 SUV39H2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SUV39H2
Molecular Function
    chromatin binding GO:0003682 IEA
    histone methyltransferase activity (H3-K9 specific) GO:0046974 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    transcription regulatory region sequence-specific DNA binding GO:0000976 ISS
Biological Process
    chromatin remodeling GO:0006338 IDA
    cell differentiation GO:0030154 IEA
    chromatin organization GO:0006325 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    chromatin assembly or disassembly GO:0006333 IMP
    histone H3-K9 trimethylation GO:0036124 ISS
    cellular response to hypoxia GO:0071456 IDA
    rhythmic process GO:0048511 IEA
    negative regulation of circadian rhythm GO:0042754 ISS
    histone H3-K9 dimethylation GO:0036123 ISS
    transcription, DNA-templated GO:0006351 IEA
    male meiosis GO:0007140 IEA
Subcellular Localization
    nuclear heterochromatin GO:0005720 IEA
    chromosome, centromeric region GO:0000775 IEA
    nucleoplasm GO:0005654 TAS
    chromatin GO:0000785 IDA
 Experiment description of studies that identified SUV39H2 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SUV39H2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cggbp1 predicted  
Two-hybrid Rattus norvegicus
2 EWSR1 2130
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SUV39H2 is involved
PathwayEvidenceSource
PKMTs methylate histone lysines TAS Reactome





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