Gene description for SUV39H2
Gene name suppressor of variegation 3-9 homolog 2 (Drosophila)
Gene symbol SUV39H2
Other names/aliases KMT1B
Species Homo sapiens
 Database cross references - SUV39H2
ExoCarta ExoCarta_79723
Vesiclepedia VP_79723
Entrez Gene 79723
HGNC 17287
MIM 606503
UniProt Q9H5I1  
 SUV39H2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SUV39H2
Molecular Function
    transcription cis-regulatory region binding GO:0000976 ISS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    histone H3K9 methyltransferase activity GO:0046974 IBA
    histone H3K9 methyltransferase activity GO:0046974 IDA
    histone H3 methyltransferase activity GO:0140938 TAS
    histone H3K9 trimethyltransferase activity GO:0140949 IEA
    S-adenosyl-L-methionine binding GO:1904047 IDA
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    chromatin organization GO:0006325 IMP
    chromatin remodeling GO:0006338 IDA
    circadian rhythm GO:0007623 ISS
    cell differentiation GO:0030154 IEA
    methylation GO:0032259 IEA
    epigenetic programming in the zygotic pronuclei GO:0044725 IDA
    negative regulation of gene expression, epigenetic GO:0045814 ISS
    negative regulation of DNA-templated transcription GO:0045892 ISS
    cellular response to hypoxia GO:0071456 IDA
Subcellular Localization
    chromosome, centromeric region GO:0000775 IEA
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified SUV39H2 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SUV39H2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF644  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 WIZ 58525
Two-hybrid Homo sapiens
3 CCDC151  
Two-hybrid Homo sapiens
4 APPL2 55198
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 CBX1 10951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CDCA4 55038
Two-hybrid Homo sapiens
7 AP4E1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 FAM20C 56975
Two-hybrid Homo sapiens
9 SHC1 6464
Two-hybrid Homo sapiens
10 LRIF1  
Two-hybrid Homo sapiens
11 CBX3 11335
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SLK 9748
Affinity Capture-MS Homo sapiens
13 GOLGA6L9  
Two-hybrid Homo sapiens
14 LCA5L  
Two-hybrid Homo sapiens
15 NME4 4833
Two-hybrid Homo sapiens
16 AKAP9 10142
Two-hybrid Homo sapiens
17 Cggbp1  
Two-hybrid Rattus norvegicus
18 BLZF1  
Two-hybrid Homo sapiens
19 KLF3  
Two-hybrid Homo sapiens
20 NUMA1 4926
Affinity Capture-MS Homo sapiens
21 RASSF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 SASH1 23328
Co-crystal Structure Homo sapiens
23 PHF19  
Two-hybrid Homo sapiens
24 VHL  
Two-hybrid Homo sapiens
25 ZNF557  
Two-hybrid Homo sapiens
26 PNMA1 9240
Two-hybrid Homo sapiens
27 KLHDC4 54758
Two-hybrid Homo sapiens
28 C8orf74  
Two-hybrid Homo sapiens
29 MYL12A 10627
Two-hybrid Homo sapiens
30 PUS7 54517
Affinity Capture-MS Homo sapiens
31 ZNF212  
Two-hybrid Homo sapiens
32 SNF8 11267
Two-hybrid Homo sapiens
33 POLR3F  
Two-hybrid Homo sapiens
34 SMAD5 4090
Affinity Capture-Western Homo sapiens
35 GSTCD 79807
Two-hybrid Homo sapiens
36 ROCK2 9475
Affinity Capture-MS Homo sapiens
37 MTF2  
Two-hybrid Homo sapiens
38 CEP70  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 EHMT2 10919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CBX5 23468
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 MRFAP1  
Two-hybrid Homo sapiens
42 ZNF57  
Two-hybrid Homo sapiens
43 RAB3IP  
Two-hybrid Homo sapiens
44 TTC9C 283237
Affinity Capture-MS Homo sapiens
45 KCTD17 79734
Two-hybrid Homo sapiens
46 EHMT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 AP4M1 9179
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 QRSL1  
Affinity Capture-MS Homo sapiens
49 CCDC37 348807
Two-hybrid Homo sapiens
50 NARS 4677
Affinity Capture-MS Homo sapiens
51 EWSR1 2130
Two-hybrid Homo sapiens
52 CHMP2B 25978
Affinity Capture-MS Homo sapiens
53 MCM3AP  
Two-hybrid Homo sapiens
54 AP4S1 11154
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CBX7  
PCA Homo sapiens
56 SH2D4A 63898
Affinity Capture-MS Homo sapiens
57 LNX1  
Two-hybrid Homo sapiens
58 ACTBL2 345651
Affinity Capture-MS Homo sapiens
59 ID2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SUV39H2 is involved
PathwayEvidenceSource
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
PKMTs methylate histone lysines TAS Reactome





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