Gene description for KCTD17
Gene name potassium channel tetramerization domain containing 17
Gene symbol KCTD17
Other names/aliases -
Species Homo sapiens
 Database cross references - KCTD17
ExoCarta ExoCarta_79734
Vesiclepedia VP_79734
Entrez Gene 79734
HGNC 25705
UniProt Q8N5Z5  
 KCTD17 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for KCTD17
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    cullin family protein binding GO:0097602 IBA
    cullin family protein binding GO:0097602 IPI
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 IDA
Biological Process
    cell projection organization GO:0030030 IEA
    endoplasmic reticulum calcium ion homeostasis GO:0032469 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP
    positive regulation of cilium assembly GO:0045724 IBA
    positive regulation of cilium assembly GO:0045724 IMP
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IEA
    Cul3-RING ubiquitin ligase complex GO:0031463 IBA
    Cul3-RING ubiquitin ligase complex GO:0031463 IDA
 Experiment description of studies that identified KCTD17 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KCTD17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 CDC42BPB 9578
Affinity Capture-MS Homo sapiens
3 GNG4  
Affinity Capture-MS Homo sapiens
4 ZNF358 140467
Affinity Capture-MS Homo sapiens
5 GLRA3  
Affinity Capture-MS Homo sapiens
6 TMEM45A  
Affinity Capture-MS Homo sapiens
7 CDK5RAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 THAP9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 PPP1R10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MTMR9 66036
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PCBP3 54039
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 MIDN 90007
Affinity Capture-MS Homo sapiens
13 PCGF2 7703
Affinity Capture-MS Homo sapiens
14 C21orf2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 NAALADL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TFAM 7019
Affinity Capture-MS Homo sapiens
17 SPECC1L 23384
Affinity Capture-MS Homo sapiens
18 ZMYND8 23613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PTPN4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 DUSP11  
Affinity Capture-MS Homo sapiens
21 IRF2BPL 64207
Affinity Capture-MS Homo sapiens
22 RECQL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TINF2  
Two-hybrid Homo sapiens
24 POLRMT 5442
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 CTC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 LACTB 114294
Affinity Capture-MS Homo sapiens
27 PSMA1 5682
Two-hybrid Homo sapiens
28 NIF3L1 60491
Two-hybrid Homo sapiens
29 SFTPC  
Affinity Capture-MS Homo sapiens
30 ZNF579  
Affinity Capture-MS Homo sapiens
31 EIF2AK2 5610
Affinity Capture-MS Homo sapiens
32 VRK3 51231
Affinity Capture-MS Homo sapiens
33 AQP1 358
Two-hybrid Homo sapiens
34 GNG8  
Affinity Capture-MS Homo sapiens
35 RBX1 9978
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
36 ARRDC1 92714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 CTU2 348180
Affinity Capture-MS Homo sapiens
38 NUDT18  
Two-hybrid Homo sapiens
39 PLD1 5337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 OPTN 10133
Affinity Capture-MS Homo sapiens
41 TUBGCP4 27229
Two-hybrid Homo sapiens
42 ACACA 31
Positive Genetic Homo sapiens
43 RGS3 5998
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TCHP  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
45 TRMT2A 27037
Affinity Capture-MS Homo sapiens
46 CYLD  
Affinity Capture-MS Homo sapiens
47 KCTD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CD93  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 PXDNL  
Affinity Capture-MS Homo sapiens
50 CGGBP1 8545
Affinity Capture-MS Homo sapiens
51 PRKCZ 5590
Affinity Capture-MS Homo sapiens
52 NARF 26502
Affinity Capture-MS Homo sapiens
53 CUL3 8452
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
54 CTU1 90353
Affinity Capture-MS Homo sapiens
55 TRIM33 51592
Affinity Capture-MS Homo sapiens
56 ACAD11 84129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 POLK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CERK 64781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TFAP4 7023
Affinity Capture-MS Homo sapiens
60 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
61 TYW3  
Affinity Capture-MS Homo sapiens
62 OBFC1 79991
Affinity Capture-MS Homo sapiens
63 CDC42BPA 8476
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 CSNK1D 1453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 RAPGEF2 9693
Affinity Capture-MS Homo sapiens
66 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 NLRP1  
Affinity Capture-MS Homo sapiens
68 SUV39H2 79723
Two-hybrid Homo sapiens
69 TERF2  
Affinity Capture-MS Homo sapiens
70 ZNF687  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 FBRS 64319
Affinity Capture-MS Homo sapiens
72 DDRGK1 65992
Affinity Capture-MS Homo sapiens
73 PDZK1 5174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ZNF696  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 FRMD6 122786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 HUWE1 10075
Affinity Capture-MS Homo sapiens
77 UBE2D1 7321
Reconstituted Complex Homo sapiens
78 LRRC18  
Two-hybrid Homo sapiens
79 CBX4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 PIP5K1A 8394
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 GNG2 54331
Affinity Capture-MS Homo sapiens
82 STK16 8576
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
83 MPLKIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 GLRA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 POLR2J  
Affinity Capture-MS Homo sapiens
86 TP53 7157
Affinity Capture-MS Homo sapiens
87 RWDD4 201965
Two-hybrid Homo sapiens
88 KLHL8  
Affinity Capture-MS Homo sapiens
89 EIF1AX 1964
Affinity Capture-MS Homo sapiens
90 DMC1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
91 KCND2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 SLC1A3 6507
Affinity Capture-MS Homo sapiens
93 POU2F1 5451
Affinity Capture-MS Homo sapiens
94 ESR1  
Affinity Capture-MS Homo sapiens
95 UFL1 23376
Affinity Capture-MS Homo sapiens
96 PPP1R9A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 ZNF57  
Affinity Capture-MS Homo sapiens
98 CEP78 84131
Affinity Capture-MS Homo sapiens
99 KCTD17 79734
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
100 GLRX3 10539
Affinity Capture-MS Homo sapiens
101 PHC2  
Affinity Capture-MS Homo sapiens
102 KCTD5 54442
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 REPIN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 DBR1  
Affinity Capture-MS Homo sapiens
105 LNX1  
Two-hybrid Homo sapiens
106 MTMR6 9107
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KCTD17 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here