Gene description for RGS3
Gene name regulator of G-protein signaling 3
Gene symbol RGS3
Other names/aliases C2PA
RGP3
Species Homo sapiens
 Database cross references - RGS3
ExoCarta ExoCarta_5998
Entrez Gene 5998
HGNC 9999
MIM 602189
UniProt P49796  
 RGS3 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for RGS3
Molecular Function
    protein binding GO:0005515 IPI
    GTPase activator activity GO:0005096 TAS
Biological Process
    inactivation of MAPK activity GO:0000188 TAS
    positive regulation of GTPase activity GO:0043547 TAS
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified RGS3 in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RGS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAE 7531
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 GNA11 2767
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 YWHAZ 7534
Invitro Homo sapiens
4 EFNB1 1947
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
5 GNAI3 2773
Affinity Capture-Western Homo sapiens
6 YWHAB 7529
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which RGS3 is involved
No pathways found





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