Gene description for SEPT10
Gene name septin 10
Gene symbol SEPT10
Other names/aliases -
Species Homo sapiens
 Database cross references - SEPT10
ExoCarta ExoCarta_151011
Vesiclepedia VP_151011
Entrez Gene 151011
HGNC 14349
MIM 611737
UniProt Q9P0V9  
 SEPT10 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Thymus 23844026    
 Gene ontology annotations for SEPT10
Molecular Function
    GTPase activity GO:0003924 IBA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
    molecular adaptor activity GO:0060090 IBA
Biological Process
    protein localization GO:0008104 IBA
    cytoskeleton-dependent cytokinesis GO:0061640 IBA
Subcellular Localization
    septin ring GO:0005940 IBA
    microtubule cytoskeleton GO:0015630 IBA
    septin complex GO:0031105 IBA
    motile cilium GO:0031514 IEA
    cell division site GO:0032153 IBA
 Experiment description of studies that identified SEPT10 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SEPT10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KIF16B 55614
Proximity Label-MS Homo sapiens
2 C1orf198 84886
Proximity Label-MS Homo sapiens
3 DLG5 9231
Proximity Label-MS Homo sapiens
4 LINC01587  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ALMS1  
Proximity Label-MS Homo sapiens
6 TGS1  
Affinity Capture-MS Homo sapiens
7 APC  
Proximity Label-MS Homo sapiens
8 SEPT14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SEPT12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 THOC7 80145
Proximity Label-MS Homo sapiens
11 MYO5C 55930
Proximity Label-MS Homo sapiens
12 DVL3 1857
Proximity Label-MS Homo sapiens
13 KIF7 374654
Proximity Label-MS Homo sapiens
14 SNX6 58533
Proximity Label-MS Homo sapiens
15 SEPT2 4735
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SEPT9 10801
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 KIF13B 23303
Proximity Label-MS Homo sapiens
18 KIF20A 10112
Proximity Label-MS Homo sapiens
19 PCNT  
Proximity Label-MS Homo sapiens
20 CNOT10 25904
Proximity Label-MS Homo sapiens
21 TBC1D31  
Proximity Label-MS Homo sapiens
22 IFT74 80173
Proximity Label-MS Homo sapiens
23 SDCCAG3  
Proximity Label-MS Homo sapiens
24 WHAMMP3  
Affinity Capture-MS Homo sapiens
25 DNMBP 23268
Proximity Label-MS Homo sapiens
26 CCDC138  
Proximity Label-MS Homo sapiens
27 ERC1 23085
Proximity Label-MS Homo sapiens
28 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PSMC2 5701
Proximity Label-MS Homo sapiens
30 SEPT8 23176
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
31 HYPM  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
32 RGPD6  
Proximity Label-MS Homo sapiens
33 SEPT7 989
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SEPT1 1731
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 CEP131 22994
Proximity Label-MS Homo sapiens
36 N4BP2  
Proximity Label-MS Homo sapiens
37 DVL2 1856
Proximity Label-MS Homo sapiens
38 TBKBP1  
Proximity Label-MS Homo sapiens
39 TCP1 6950
Proximity Label-MS Homo sapiens
40 CEP55 55165
Proximity Label-MS Homo sapiens
41 PARK2  
Affinity Capture-MS Homo sapiens
42 CEP192 55125
Proximity Label-MS Homo sapiens
43 SIPA1L1 26037
Proximity Label-MS Homo sapiens
44 OFD1 8481
Proximity Label-MS Homo sapiens
45 SUGT1 10910
Proximity Label-MS Homo sapiens
46 Sept11  
Affinity Capture-MS Mus musculus
47 GCC2 9648
Proximity Label-MS Homo sapiens
48 CEP152  
Proximity Label-MS Homo sapiens
49 RGS3 5998
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 AKAP9 10142
Proximity Label-MS Homo sapiens
51 NRBF2  
Proximity Label-MS Homo sapiens
52 TRIM11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 SPAG5 10615
Proximity Label-MS Homo sapiens
54 CCDC22 28952
Proximity Label-MS Homo sapiens
55 PPP1R14B 26472
Co-fractionation Homo sapiens
56 ANKRD26 22852
Proximity Label-MS Homo sapiens
57 KIF20B  
Proximity Label-MS Homo sapiens
58 LRCH3 84859
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
59 SSX2IP  
Proximity Label-MS Homo sapiens
60 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 IMMT 10989
Cross-Linking-MS (XL-MS) Homo sapiens
62 ALAD 210
Co-fractionation Homo sapiens
63 HSPA5 3309
Affinity Capture-MS Homo sapiens
64 RAP1GDS1 5910
Proximity Label-MS Homo sapiens
65 LSM8 51691
Two-hybrid Homo sapiens
66 SLC3A2 6520
Proximity Label-MS Homo sapiens
67 KIF15 56992
Proximity Label-MS Homo sapiens
68 XPO1 7514
Affinity Capture-MS Homo sapiens
69 LMNB1 4001
Proximity Label-MS Homo sapiens
70 DEPDC1B 55789
Proximity Label-MS Homo sapiens
71 SEPT4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 SEPT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CDC42EP1 11135
Proximity Label-MS Homo sapiens
74 CUL3 8452
Affinity Capture-MS Homo sapiens
75 CCP110  
Proximity Label-MS Homo sapiens
76 CKAP2  
Proximity Label-MS Homo sapiens
77 SEPT11 55752
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 EPRS 2058
Proximity Label-MS Homo sapiens
79 DUSP16  
Affinity Capture-MS Homo sapiens
80 CORO1C 23603
Co-fractionation Homo sapiens
81 YTHDC1  
Two-hybrid Homo sapiens
82 CDC42BPA 8476
Proximity Label-MS Homo sapiens
83 Sept2  
Affinity Capture-MS Mus musculus
84 SLAIN2  
Proximity Label-MS Homo sapiens
85 KIF1BP 26128
Proximity Label-MS Homo sapiens
86 NIN 51199
Proximity Label-MS Homo sapiens
87 Sept6  
Affinity Capture-MS Mus musculus
88 SIRT2 22933
Proximity Label-MS Homo sapiens
89 PCM1 5108
Proximity Label-MS Homo sapiens
90 CCDC88A 55704
Proximity Label-MS Homo sapiens
91 CEP350 9857
Proximity Label-MS Homo sapiens
92 ANKRD28 23243
Proximity Label-MS Homo sapiens
93 POLR1D 51082
Affinity Capture-MS Homo sapiens
94 CDC42EP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
95 RBM11  
Proximity Label-MS Homo sapiens
96 SEPT5 5413
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 GOLGB1 2804
Proximity Label-MS Homo sapiens
98 MPHOSPH9  
Proximity Label-MS Homo sapiens
99 HK2 3099
Co-fractionation Homo sapiens
100 RALBP1 10928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 DVL1 1855
Proximity Label-MS Homo sapiens
102 TTC1 7265
Proximity Label-MS Homo sapiens
103 KIAA0753  
Proximity Label-MS Homo sapiens
104 DNAJA2 10294
Proximity Label-MS Homo sapiens
105 CDK5RAP2 55755
Proximity Label-MS Homo sapiens
106 RNF214  
Proximity Label-MS Homo sapiens
107 CENPF 1063
Proximity Label-MS Homo sapiens
108 FKBP4 2288
Proximity Label-MS Homo sapiens
109 NUDT19 390916
Proximity Label-MS Homo sapiens
110 Sept7  
Affinity Capture-MS Mus musculus
111 SIRT1  
Proximity Label-MS Homo sapiens
112 TRIP11 9321
Proximity Label-MS Homo sapiens
113 CEP44  
Proximity Label-MS Homo sapiens
114 ACAP3 116983
Affinity Capture-MS Homo sapiens
115 KRT38 8687
Affinity Capture-MS Homo sapiens
116 KRT8 3856
Proximity Label-MS Homo sapiens
117 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
118 CCDC96  
Affinity Capture-MS Homo sapiens
119 PSMC4 5704
Proximity Label-MS Homo sapiens
120 Sept9  
Affinity Capture-MS Mus musculus
121 SEPT6 23157
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 PSME4 23198
Co-fractionation Homo sapiens
123 CNTROB  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SEPT10 is involved
No pathways found





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