Gene description for ACAP3
Gene name ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Gene symbol ACAP3
Other names/aliases CENTB5
Species Homo sapiens
 Database cross references - ACAP3
ExoCarta ExoCarta_116983
Vesiclepedia VP_116983
Entrez Gene 116983
HGNC 16754
UniProt Q96P50  
 ACAP3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ACAP3
Molecular Function
    GTPase activator activity GO:0005096 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    neuron migration GO:0001764 IEA
    regulation of neuron projection development GO:0010975 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    growth cone GO:0030426 IEA
 Experiment description of studies that identified ACAP3 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ACAP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIF1AN 55662
Affinity Capture-MS Homo sapiens
2 SEPT3  
Affinity Capture-MS Homo sapiens
3 SEPT9 10801
Affinity Capture-MS Homo sapiens
4 EIF6 3692
Two-hybrid Homo sapiens
5 SEPT7 989
Affinity Capture-MS Homo sapiens
6 FBXW11  
Affinity Capture-MS Homo sapiens
7 SEPT5 5413
Affinity Capture-MS Homo sapiens
8 TXNDC16 57544
Affinity Capture-MS Homo sapiens
9 SEPT10 151011
Affinity Capture-MS Homo sapiens
10 TAB1 10454
Two-hybrid Homo sapiens
11 SEPT6 23157
Affinity Capture-MS Homo sapiens
12 SEPT8 23176
Affinity Capture-MS Homo sapiens
13 ACAP2 23527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SEPT11 55752
Affinity Capture-MS Homo sapiens
15 XPO1 7514
Affinity Capture-MS Homo sapiens
16 RBM25 58517
Affinity Capture-MS Homo sapiens
17 DDX58 23586
Affinity Capture-RNA Homo sapiens
18 SEPT2 4735
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ACAP3 is involved
No pathways found





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